Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation.
Conclusions. Increased ICAM-1 expression in ethanol-treated fatty livers predisposes to leukocyte adherence after LT, which leads to a disturbed microcirculation, oxidative stress and graft injury.
PMID: 22778492 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Biliary cystadenomas: a case for complete resection.
Conclusion. Biliary cystadenoma must be differentiated from other benign cysts. Hepatic resection or cyst enucleation is the recommended treatment option.
PMID: 22778493 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation.
In conclusion, JNK2 contributes to MPT-mediated liver injury after H/R.
PMID: 22791932 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Desferrioxamine Attenuates Pancreatic Injury after Major Hepatectomy under Vascular Control of the Liver: Experimental Study in Pigs.
Conclusions. Desferrioxamine seems to attenuate pancreatic injury after major hepatectomy under vascular control possibly by preventing and reversing production and circulation of oxidative products.
PMID: 22791933 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Effects of a preconditioning oral nutritional supplement on pig livers after warm ischemia.
Conclusion. Administration of pONS before and after tissue damage protects the liver from warm IRI via mechanisms including decreasing oxidative stress, lipid peroxidation, apoptosis, and necrosis.
PMID: 22791934 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Klatskin-like lesions.
Authors: Senthil Kumar MP, Marudanayagam R
Abstract
Hilar cholangiocarcinoma, also known as Klatskin tumour, is the commonest type of cholangiocarcinoma. It poses unique problems in the diagnosis and management because of its anatomical location. Curative surgery in the form of major hepatic resection entails significant morbidity. About 5-15% of specimens resected for presumed Klatskin tumour prove not to be cholangiocarcinomas. There are a number of inflammatory, infective, vascular, and other pathologies, which have overlapping clinical and radiological features with a Klatskin tumour, leading to misint...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Hepatocellular adenoma: evaluation with contrast-enhanced ultrasound and MRI and correlation with pathologic and phenotypic classification in 26 lesions.
Conclusion. In half cases, inflammatory HCA have specific imaging features well correlated with the amount of telangiectasia and inflammatory infiltrates. An HCA with important amount of steatosis noticed on chemical shift images does not always belong to the HNF1α group.
PMID: 22811588 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation.
In conclusion, ischemic preconditioning markedly decreased cell killing after subsequent sustained warm ischemia. Most importantly, ischemic preconditioning restored 100% graft survival of livers harvested from non-heart-beating donors after 60 min of aortic clamping.
PMID: 22888183 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Reactive lymphoid hyperplasia of the liver: a clinicopathological study of 7 cases.
Conclusions. RLH of the liver is a rare benign disease with a female predilection of unknown etiology. It is very difficult to correctly diagnose this disease without pathological results. Subtle differences on radiological findings of it may be helpful for differential diagnosis from other diseases. Curative resection of the lesion is suggested for the treatment of this disease.
PMID: 22899877 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Laparoscopy in Liver Transplantation: The Future has Arrived.
Authors: Lai Q, Pinheiro RS, Levi Sandri GB, Spoletini G, Melandro F, Guglielmo N, Di Laudo M, Frattaroli FM, Berloco PB, Rossi M
Abstract
In the last two decades, laparoscopy has revolutionized the field of surgery. Many procedures previously performed with an open access are now routinely carried out with the laparoscopic approach. Several advantages are associated with laparoscopic surgery compared to open procedures: reduced pain due to smaller incisions and hemorrhaging, shorter hospital length of stay, and a lower incidence of wound infections. Liver transplantation (LT) brought a radical change in l...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
"Incidentaloma" of the liver: management of a diagnostic and therapeutic dilemma.
Authors: Ehrl D, Rothaug K, Herzog P, Hofer B, Rau HG
Abstract
The continuous development of highly sensitive clinical imaging increased the detection of focal lesions of the liver. These accidentally detected liver tumors without liver-specific symptoms such as cholestasis have been named "incidentalomas." Diagnostic tools such as sonography, computed tomography, or magnetic resonance imaging are used increasingly in asymptomatic individuals without defined suspected diagnoses in the setting of general prevention or followup after a history of malignancy. But despite continuous improvement of diagnostics,...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Glycemic control after total pancreatectomy for intraductal papillary mucinous neoplasm: an exploratory study.
Conclusion. This suggests that glycemic control following TP for IPMNcan be well managed, similar to type 1 DM patients. Fear of DM following TP for IPMN should not preclude surgery when TP is indicated.
PMID: 22966212 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones-a review.
Authors: Laukkarinen J, Sand J, Nordback I
Abstract
For decades, one well-known risk factor for the development of gallbladder stones has been hypothyroidism. Recent studies have interestingly reported that the risk in particular for common bile duct (CBD) stones increases in clinical and subclinical hypothyroidism. There are multiple factors that may contribute to the formation and/or accumulation of CBD stones in hypothyroid patients, including decreased liver cholesterol metabolism, diminished bile secretion, and reduced sphincter of Oddi relaxation. This paper focuses on the mechanisms possibly underly...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Surgical options for initially unresectable colorectal liver metastases.
Authors: Popescu I, Alexandrescu ST
Abstract
Although the frontiers of liver resection for colorectal liver metastases have broadened in recent decades, approximately 75% of these patients present with unresectable metastases at the time of their diagnosis. In the past, these patients underwent only palliative treatment, without the chance of a cure. In the previous two decades, several therapeutic strategies have been developed that render resectable those metastases that were initially unresectable, thus offering the chance of long-term survival and even a cure to these patients. The oncosurgical modalit...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Initial experiences of simultaneous laparoscopic resection of colorectal cancer and liver metastases.
Conclusions. From this initial single-center experience, simultaneous laparoscopic colorectal and liver resection appears to be feasible in selected patients with CRC and SLM, with satisfying short-term results.
PMID: 23082043 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
