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Serial changes in delayed focal hippocampal lesions in patients with transient global amnesia.
Authors: Ueno H, Naka H, Ohshita T, Wakabayashi S, Matsumoto M Abstract The etiology of transient global amnesia (TGA) is not well understood. MR studies, including studies using diffusion-weighted imaging (DWI), have been used to investigate the pathophysiology of TGA, and focal hippocampal lesions have been detected in some studies. The aim of this study was to investigate serial changes in MR images from the patients with TGA. In seven TGA patients, serial MRI scans (from the same day of the onset to several days after the onset of symptoms) using a 1.5-T MR unit were prospectively evaluated. In four pa...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Norovirus gastroenteritis accompanied by ischemic colitis: a case report.
Authors: Zenda T, Kaneko S, Noriki S Abstract A 57-year-old woman was admitted to our hospital because of frequent bloody diarrhea, vomiting, and abdominal cramps. While the patient was diagnosed with norovirus gastroenteritis based on the presence by chance of positive norovirus antigen in the stool samples, endoscopic as well as pathological examinations demonstrated left-sided ischemic colitis. The patient soon recovered solely by supportive treatment. Although it is believed that patients with viral gastroenteritis do not develop bloody diarrhea, the present case suggested that conditions of viral gast...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Trans-differentiation of a duodenal phenotype on duodenal transplantation of different normal tissues in F344 rats.
Authors: Watanabe H, Kominami Y, Gon R, Hayashi M, Nishiki M, Sasaki A, Shiraishi M, Ueda S, Ochiya T, Kamiya K Abstract The mechanisms regulating stem cell differentiation and self-renewal are largely unknown. Our ultimate goal is to be able to regulate somatic stem cell differentiation and proliferation. In the present study the ability of trans-differentiation was studied when different normal tissue types were transplanted into the duodenum in rats. Pieces of ear (skin), bladder, trachea, diaphragm, pyloric gland, and forestomach from 8-week old GFP-F344 rats were transplanted into the duodenum of F344...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy.
Authors: Nagao S, Hattori N, Fujitaka K, Iwamoto H, Ohshimo S, Kanehara M, Ishikawa N, Haruta Y, Murai H, Kohno N Abstract Bisphosphonates are widely used for the treatment of metastatic skeletal tumors and hypercalcemia resulting from malignant tumors. Zoledronic acid (ZOL), a third-generation bisphosphonate agent, was recently demonstrated to show synergistic antitumor activity of ZOL when combined with chemotherapy in lung cancer patients. However, whether ZOL exerts direct antitumor activity on lung cancer remains unclear. Here, we report an atypical case encountered while treating a 57-year-old woman ...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report.
Authors: Harada T, Ishizaki F, Horie N, Katsuoka H, Nitta Y, Yamada T, Nitta K, Ito M Abstract An 81-year-old man diagnosed with alcohol-induced persistent mild cognitive impairment consulted our clinic presenting with gait disturbance. Between the ages of 20 and 53 years, his alcohol consumption was 1.8 liters of alcoholic sake per day. However, from the age of 53 years onward, his consumption decreased to 360 ml per day. The patient had alcoholic neuropathy, mild cognitive impairment, and alcoholic cerebellar disorder. His score on the revised version of Hasegawa's Dementia Scale (HDS-R) was 22 and his c...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Portal-systemic shunt between the inferior mesenteric vein and inferior vena cava in a patient with hepatic encephalopathy: successful occlusion by balloon-occluded retrograde transvenous obliteration.
We report a patient with hepatic encephalopathy due to a large IMV-IVC shunt who was successfully treated by balloon-occluded retrograde transvenous obliteration. The procedure involved a combination of 11 metallic coils and 5 ml of 5% ethanolamine oleate with iopamidol as the sclerosing agent. After complete obliteration of the shunt, his symptoms disappeared. At 2-years follow-up he was free of clinical symptoms, the size of his liver had slightly increased, and his liver function was preserved. PMID: 21675043 [PubMed - indexed for MEDLINE] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Advanced esophageal cancer with situs inversus totalis successfully treated with chemoradiotherapy followed by esophagectomy: case report.
We report a case of advanced esophageal cancer successfully treated with neoadjuvant chemoradiotherapy followed by esophagectomy in a 53-year-old man with situs inversus totalis. Upper gastrointestinal endoscopy in a clinical examination revealed a tumor in the lower third of the esophagus, and moderately differentiated squamous cell carcinoma was diagnosed from the biopsy findings. He was referred to us and the disease was diagnosed as esophageal cancer (clinical T3N1M0, cStage III) after further evaluation. According to the therapeutic strategy of our department, neoadjuvant chemoradiotherapy was commenced. The regimen w...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer.
In conclusion, our findings revealed the significance of fine-tuning mechanisms for Mel-18 protein expression level in the maintenance of TIC into SP fractions in mouse breast cancer. PMID: 21970185 [PubMed - indexed for MEDLINE] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Control of dry weight and tube feeding improved the general condition of a hemodialysis patient: report of a case.
Authors: Nakatani H, Shoji H, Shibata M, Yoshida M, Tadokoro Y, Ogura N, Inoue Y, Hanazaki K, Hamada S, Kawamura A Abstract Patients on long-term hemodialysis are at risk of developing malnutrition,and poor nutrient intake is an important factor in this. In the present case, we encountered a 55-year-old Japanese woman with end-stage renal failure and a past history of schizophrenia. Severe systemic edema was observed. Hemodialysis was started, but after one year she suddenly became unable to consume food orally, despite provision of a dietary plan by the nutrition support team (NST). Tube feeding was event...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Norovirus gastroenteritis accompanied by marked elevation of transaminases.
Authors: Zenda T, Miyamoto M, Kaneko S Abstract A 56-year-old woman was admitted because of frequent watery diarrhea, vomiting, and abdominal cramps. An examination of the stool for norovirus antigen was positive, and a blood examination revealed a marked elevation of liver enzymes. Liver dysfunction, as well as symptoms related to gastroenteritis, was ameliorated solely by supportive treatment. Although liver injury concurrent with norovirus gastroenteritis is rarely documented and its pathogenesis remains unknown, clinicians should consider liver injury as one of the possible extra-intestinal manifestati...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Late recurrence of intractable epilepsy associated with MRI-occult pilocytic astrocytoma in the temporal lobe nine years after initial removal: a case report with surgical and late-seizure recurrence observations.
Authors: Nishimoto T, Iida K, Kagawa K, Watanabe Y, Kiura Y, Hashizume A, Sugiyama K, Kurisu K Abstract A 28-year-old male who presented a relapse of intractable epilepsy consisting of complex partial seizures with occasional secondary generalizations at the age of 26, had undergone removal of a left mesial temporal lobe tumor at another hospital at 18 years old. Pathological examination at that time revealed a low-grade astrocytoma, and the tumor was further treated by complementary adjuvant irradiation therapy. Magnetic resonance imaging (MRI) findings on admission portrayed a post-operative cavity anter...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Six-year experience of permanent prostate brachytherapy for clinically localized prostate cancer.
This study evaluated the efficacy of PPB in these patients. The median patient age was 69 years (range 53 to 82 years), the median prostate-specific antigen (PSA) value before biopsy was 6.75 ng/ml (range 3.5 to 47.9 ng/ml), and the median prostate volume was 23.1 ml (range 10.1 to 57 ml). The median follow-up was 37 months (range 1 to 72 months). The serum PSA levels decreased continuously after PPB throughout the entire follow-up period in 97% of patients without neoadjuvant hormonal therapy. No relapse occurred during the follow-up period in patients at low risk. Our 6-year experience suggests that PPB is effective for ...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
In conclusion, the measurement of baseline 3-OMD and levodopa pharmacokinetics is useful for predicting the clinical effects of entacapone. PMID: 22053701 [PubMed - indexed for MEDLINE] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Detection of large expansions in SCA8 using a fluorescent repeat-primed PCR assay.
In this study, we applied a fluorescent PCR method for detection of expanded repeats in the ATXN8OS/ATXN8 gene. Although this test cannot give a precise estimate of the size of the expansion, it proved useful for confirming the presence of expansions in SCA8. PMID: 22053702 [PubMed - indexed for MEDLINE] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

A case of idiopathic intracranial hypertension related with vesicoureteral reflux.
Authors: Akgün C, Taşkin GA, Akbayram S, Kaya A, Temel H, Yuca SA, Caksen H Abstract Pseudotumor cerebri is idiopathic intracranial hypertension. The etiology of this syndrome has not been fully clarified. Excess cerebrospinal fluid production, scarcity of cerebrospinal fluid absorption, intracranial venous pressure elevation, increased intracranial blood volume are all thought to be responsible. The symptoms of the disease may be ordered according to prevalence as follows: headache due to increased intracranial pressure, blurred vision and diplopia. A thirteen-year-old female patient was brought in with...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research