Hiroshima Journal of Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Surgical Resection of Thoracic Esophageal Cancer with Interstitial Lung Disease: A Case Report.
We describe a patient with stage IA esophageal cancer accompanied by interstitial lung disease (ILD). Endoscopic resection and radiotherapy were not appropriate because of clinically diagnosed submucosal invasion and the patient was at high risk of ILD exacerbation. We therefore selected transhiatal esophagectomy without a thoracotomy considering the risk of postoperative respiratory complications, and administered methylprednisolone and sivelestat in the perioperative period for the reduction of surgical stress. To our knowledge, this is the first report of surgical treatment for esophageal cancer with ILD. The patient wa...
Source: Hiroshima Journal of Medical Sciences - July 1, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Diagnostic Performance of Positron Emission Tomography for the Presurgical Evaluation of Patients with Non-lesional Intractable Partial Epilepsy: Comparison among 18F-FDG, 11C-Flumazenil, and 11C-Flumazenil Binding Potential Imaging Using Statistical Imaging Analysis.
Authors: Komoto D, Iida K, Higaki T, Kaichi Y, Takauchi K, Arihiro K, Kakita A, Hirokawa Y, Awai K Abstract To compare the diagnostic performance of 18F-FDG PET, 11C-FMZ PET, and 11C-FMZ BP imaging for the evaluation of patients with intractable partial epilepsy whose MRI findings are normal by using statistical imaging analysis. Ten patients underwent comprehensive presurgical evaluation, including PET studies, to assess the epileptic foci. The extent of cortical resection was based on the results of intracranial video-electroencephalography (IVEEG) monitoring and brain mapping under stimulation. The imag...
Source: Hiroshima Journal of Medical Sciences - March 12, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Solitary Cranial Langerhans Cell Histiocytosis: Two case reports.
We describe the clinical and histologic spectrum of LCH of the orbit and skull in our two cases. Both cases had unifocal erosive skull lesions with a history of trauma. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. LCH has an excellent prognosis when treated with surgical resection, steroids and radiotherapy or chemotherapy. One of our patients is disease free at 7 year follow-up and one patient had regression of lesion on follow-up. ...
Source: Hiroshima Journal of Medical Sciences - March 12, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Complete Response Obtained with S-1 Plus CDDP Therapy in a Patient with Multiple Liver Metastases from Gastric Cancer.
Authors: Nonoshita T, Otsuka S, Inagaki M, Iwagaki H Abstract A 58-year-old woman with advanced gastric cancer underwent total gastrectomy in May 2012. The histological diagnosis was poorly differentiated adenocarcinoma, cT4a (SE), pN1, cM0; fStage IIIA. Chemotherapy by S-1 was started after surgery. Six months after the operation, two metastatic nodules were noticed on the liver. Therefore, the chemotherapy was switched to S-1 plus cisplatin (CDDP) in November 2012. TS-1 (80 mg/body) was administrated from day 1 to 21 followed by 14 days rest as one course. CDDP (70 mg/body) was infused on day 1. After 3 ...
Source: Hiroshima Journal of Medical Sciences - March 12, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Propofol for Anesthesia and Postoperative Sedation Resulted in Fewer Inflammatory Responses than Sevoflurane Anesthesia and Midazolam Sedation after Thoracoabdominal Esophagectomy.
Authors: Nakanuno R, Yasuda T, Hamada H, Yoshikawa H, Nakamura R, Saeki N, Kawamoto M Abstract Responses to surgical stress can be modulated by anesthetics. We prospectively compared the effects of two different anesthetic/sedative techniques on the peak postoperative bladder temperature (BT) and the postoperative C-reactive protein (CRP) level. Twenty patients who were scheduled to undergo elective thoracoabdominal esophagectomy were allocated to receive either propofol anesthesia followed by propofol sedation (PP group, n = 10) or sevoflurane anesthesia followed by midazolam sedation (SM group, n = 10). ...
Source: Hiroshima Journal of Medical Sciences - December 23, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Effect of Revascularization on Headache Associated with Moyamoya Disease in Pediatric Patients.
Authors: Bohara M, Sugata S, Nishimuta Y, Karki P, Nagayama T, Sakamoto S, Tokimura H, Arita K Abstract Episodic headache is common in childhood moyamoya disease (MMD). The onset, mechanism, cause of headache and the effect of revascularization surgery on headache are not yet clear. We studied 10 cases of children (7 boys and 3 girls) younger than 18 years who underwent revascularization for MMD between 2009 and 2013. We evaluated frequency of headache and cerebral blood flow changes by single photon emission computed tomography brain imaging with [I123]-labeled iofetamine (IMP-SPECT) before and after surg...
Source: Hiroshima Journal of Medical Sciences - December 23, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Mirizzi Syndrome with a Biliobiliary Fistula: a case report.
Authors: Sakoda T, Murakami Y, Kondo N, Uemura K, Hashimoto Y, Nakagawa N, Sueda T Abstract Mirizzi syndrome is a rare complication of cholelithiasis, which is defined as a common bile duct obstruction due to stones impacted in Hartman's pouch or the cystic duct of the gallbladder. The impacted stones and surrounding inflammation can lead to a biliobiliary fistula. We herein present the case of a 73-year-old Japanese man with a biliobiliary fistula that was diagnosed by peroral cholangiography (POCS). We performed partial cholecystectomy and choledochoplasty as the stone had eroded almost the entire circum...
Source: Hiroshima Journal of Medical Sciences - December 23, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Inference on biological mechanisms using an integrated phenotype prediction model.
Authors: Enomoto Y, Ushijima M, Miyata S, Matsuura M, Ohtaki M Abstract We propose a methodology for constructing an integrated phenotype prediction model that accounts for multiple pathways regulating a targeted phenotype. The method uses multiple prediction models, each expressing a particular pattern of gene-to-gene interrelationship, such as epistasis. We also propose a methodology using Gene Ontology annotations to infer a biological mechanism from the integrated phenotype prediction model. To construct the integrated models, we employed multiple logistic regression models using a two-step learning ap...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Effect of angiotensin converting enzyme inhibitor and benzodiazepine intake on bone loss in older Japanese.
Authors: Masunari N, Fujiwara S, Nakata Y, Furukawa K, Kasagi F Abstract We investigated the effects of several frequently described medication regimens on annual percentage change in bone mineral density (BMD). A longitudinal cohort study (a retrospective analysis) was conducted. Subjects in the Adult Health Study (a prospective cohort study begun in 1958) have been followed through biennial medical examinations in Hiroshima, Japan. Participants were 2,111 subjects (67% women; aged 47-95 years) who were undergoing biennial health examinations from 1994 to 2000. The subjects were examined for the effect of...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Health status of radiation exposed residents living near the Semipalatinsk Nuclear Test Site based on health assessment by interview.
Authors: Hirabayashi K, Kawano N, Ohtaki M, Harada Y, Harada H, Muldagaliyev T, Apsalikov K, Hoshi M Abstract The purpose of the present paper is to examine the aftereffects of radiation exposure on residents of villages near the Semipalatinsk Nuclear Test Site (SNTS) in Kazakhstan. Our Hiroshima University (Japan) research team began field research in 2002 by means of health assessments conducted via interviews. We focus on persons who responded to questions concerning their medical conditions and symptoms. In this paper, we summarize and analyze, using multiple linear logistic regression analysis, the an...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Dose-finding study of anti-CD25 antibody for targeting regulatory T cells in locoregional immunotherapy of malignant effusion.
Authors: Okawaki M, Yamaguchi Y, Okita R, Ohara M, Okada M Abstract Effects of low-dose anti-CD25 antibody on targeting regulatory T (Treg) cells in vitro and in vivo were investigated. Human-mouse chimeric anti-CD25 monoclonal antibody basiliximab was administered into the effusion cavity, followed by locoregional immunotherapy using OK-432 on day 7. Peripheral blood mononuclear cells and effusion lymphocytes (ELs) were collected before and after the basiliximab administration and subjected to further investigations. Surface phenotypes, IFN-gamma production, cytotoxic activity and foxp3 expression of ELs ...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Multiple concurrent anastomotic procedures in the management of moyamoya disease: a case report with review of literature.
Authors: Shrestha P, Sakamoto S, Ohba S, Shibukawa M, Kiura Y, Okazaki T, Takeda M, Sugiyama K, Kurisu K Abstract It has already been proved by many studies that surgical revascularization definitely helps in curing the symptoms of moyamoya vasculopathy. In this regard, we present a case of moyamoya disease which was cured by concurrent multiple anastomotic procedures, namely superficial temporal artery (STA), middle cerebral artery (MCA) anastomosis, encephalomyosynangiosis (EMS) and encephalogaleosynangiosis (EGS). A 24-year-old woman presented with symptoms of cerebral ischemia. Thorough investigation w...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Different role of macrophages and vascular smooth muscle cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbit between aorta and coronary artery.
Authors: Ohtani H, Shingu T, Chayama K, Hayashi K Abstract The WHHL rabbit is often used to investigate the pathogenesis of atherosclerosis. Here we elucidate differences in the pathogenesis of atherosclerosis in coronary arteries (CA) and aorta (AO) by comparing dynamic changes in the distribution of vascular smooth muscle cells (VSMCs), macrophages, collagen and extracellular deposit during atherosclerosis in WHHL rabbits. Sections of CA and AO were obtained at the early, transitional and advanced stages of atherosclerosis and stained with hematoxilin-eosin, elastica van Gieson, antibodies specific to th...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Regression analysis of maternal smoking effect on birth weight.
Authors: Nijiati K, Satoh K, Otani K, Kimata Y, Ohtaki M Abstract Risk factors for low birth weight (LBW) have been indicated in many studies, but in Japan few studies have examined the amount of reduction in birth weight (BW). The goal of this study was to examine the association between maternal smoking among pregnant women and subsequent reduction in BW, corrected by the effect of potential confounders. To assess the effect of background factors other than maternal smoking, we established a model to estimate the contribution of each explanatory variable using logarithmic multiple regression. We then use...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Efficacy of latanoprost when stored at room temperature.
Authors: Mochizuki H, Itakura H, Takamatsu M, Kiuchi Y Abstract We compared the ocular hypotensive effect for 24 hours and the tolerability of latanoprost stored at 4 degrees C and 30 degrees C. Seventeen healthy volunteers were included in this crossover trial. Latanoprost 0.005% (Xalatan) was stored at 4 degrees C or 30 degrees C for 4 weeks in the dark. The subjects enrolled to the study were randomly assigned to receive either latanoprost stored at 4 degrees C or that stored at 30 degrees C. The eye drop was applied to the right eye of each subject for 3 days. The left eye served as a control without a...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research