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Role of vascular endothelial growth factor-C and -D mRNA in breast cancer.
Authors: Teramoto S, Arihiro K, Koseki M, Kataoka T, Asahara T, Ohdan H Abstract Vascular endothelial growth factor (VEGF)-C and VEGF-D belong to the VEGF family, and are thought to be involved in lymphangiogenesis and angiogenesis. At present, this is the only known system that can induce lymphatic vessel growth in the body. However, the roles of VEGF-C and VEGF-D in breast cancer tissue have not been clarified. In the present study, we measured the mRNA expression of VEGF-C and VEGF-D in the breast cancer tissue of 109 patients by real-time polymerase chain reaction (RT-PCR). Between non-infiltrating bre...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Early induction of PMX-DHP improves oxygenation in severe sepsis patients with acute lung injury.
Authors: Suyama H, Kawasaki Y, Morikawa S, Kaneko K, Yamanoue T Abstract Direct hemoperfusion with polymyxin B-immobilized fibers (PMX-DHP) has been widely regarded as a treatment modality for septic shock in Japan. Recently, it was reported that PMX significantly improved the P/F (PaO2/FiO2) ratio in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). The aim of this study was to examine whether the phase of sepsis is related to the effects of PMX-DHP treatment on oxygenation in patients with ALI and ARDS. Thirty-four patients who had ALI or ARDS with severe sepsis were in...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

How valid is the self-administered visual analogue scale for assessing the health status of elderly people?
This study was conducted to verify the validity of the self-administered visual analogue scale (VAS) for assessing the health status of elderly people. A survey was conducted in two villages in western Japan in 2003. A total of 2040 participants, aged between 60 and 75 years, completed questionnaires comprising the VAS and six Likert-type items for health status, physical strength, life enjoyment, appetite, sleep, and life satisfaction. Data of the valid participants who properly completed both the VAS and the Likert-type item on health status were analyzed (n=1579, 77.4%). Among the Likert-type items, the VAS score was th...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

The relationship between stress levels and biological responses in a clinical nursing practicum.
Authors: Chikamura C, Iida T, Ishizaki F, Aoi S, Kobayashi T, Kataoka T Abstract We evaluated the association between the stress levels and biological responses of nursing students in a clinical practicum. The subjects consisted of 28 third-year nursing students at the nursing department of College A. The degree of stress was evaluated using the Japanese version of the State Trait Anxiety Inventory (STAI). As parameters of biological responses, serum estrogen, salivary cortisol, and salivary IgA were measured. These measurements were performed twice (before and during the clinical practicum). Before and du...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Airway Scope for emergency intubations: usefulness of a new video-laryngoscope.
In this study, we tested the usefulness of the AWS for tracheal intubation in acute, urgent situations. Patients admitted to the Advanced Emergency and Critical Care Center at Hiroshima University Hospital and who required orotracheal intubations were prospectively enrolled. Tracheal intubations were performed using the AWS by residents (the novice group) or staff physicians (the experienced group), who received a brief instruction in the AWS. We enrolled 38 patients (23 males, 15 females; age, 60 +/- 19 years). Intubations were attempted by 22 intubators (11 residents and 11 experienced personnel). The durations from inse...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Neural correlates of alexithymia in response to emotional stimuli: a study of anorexia nervosa patients.
Authors: Miyake Y, Okamoto Y, Onoda K, Shirao N, Mantani T, Yamawaki S Abstract Individuals with alexithymia are typically unable to identify, understand, or describe their own emotions. Patients with anorexia nervosa (AN) have been shown to have high levels of alexithymia, and the latter trait may play an important role over the course of AN. However, relatively little is known about the underlying neurobiological relationships between alexithymia and AN. The aim of this study was to investigate the relationship between alexithymia level and brain activation in patients with AN. Thirty female patients par...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Thiamylal and thiopental attenuate beta-adrenergic signaling pathway by suppressing adenylyl cyclase in rat ventricular myocytes.
Authors: Hidaka I, Kurokawa H, Yasuda T, Hamada H, Kawamoto M, Yuge O Abstract The effects of intravenous anesthetics on myocytes have not been fully elucidated. To investigate the effects of various intravenous anesthetics such as fentanyl, morphine, ketamine, diazepam, midazolam, thiamylal, and thiopental on the beta-adrenergic signaling pathway, we measured isoproterenol-stimulated cyclic adenosine monophosphate (cAMP) production in freshly isolated rat ventricular myocytes. Fentanyl, morphine, ketamine, diazepam, and midazolam did not significantly affect isoproterenol-stimulated cAMP production. Howev...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning.
In this study in dogs, we compared the hemodynamic patterns of hepatocellular carcinoma (HCC), one of the malignant tumors, and nodular hyperplasia (NH), a benign tumor that is more common in older dogs. Thirty-six dogs with HCC and 40 dogs with NH, which were histopathologically diagnosed at Taniura Animal Hospital, were used as subjects. Dynamic CT scanning was performed and the data of each scanning phase were collected. Dilated blood vessels, septum formation, and capsule formation were noted in the tumors from 25, 17, and 25 animals with HCC, respectively. In the arterial phase, high density and low contrast were note...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

A cure Weibull gamma-frailty survival model and its application to exploring the prognosis factors of neuroblastoma.
Authors: Dokhi M, Ohtaki M, Hiyama E Abstract The log rank test and the Cox regression, or modifications thereof, emphasize the effect of covariates on survival rate parameter. In some cases, cured individuals, i.e., individuals who may not experience the event of interest may exist in the population of interest. In this situation, we may wish to examine the effect of covariates on both survival rate and cured fraction parameters. Motivated by the Japanese neuroblastoma dataset, we consider a cure model that accounted for the effect of covariates on both of the abovementioned parameters. To deal with heter...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Induction of gamma delta T cells using zoledronate plus interleukin-2 in patients with metastatic cancer.
In this study, the induction of HLA-unrestricted effector cells, gamma delta T cells, using zoledronate (ZOL) and interleukin (IL)-2 in vitro was investigated in patients with metastatic cancer. Peripheral blood mononuclear cells (PBMCs) from 10 cancer patients (8 colorectal and 2 esophageal) with multiple metastases and ascites lymphocytes from 3 cancer patients (1 gastric and 2 colorectal) were stimulated with varied concentrations of ZOL plus 100 U/ml IL-2 for 48 hr followed by culturing with IL-2 alone for 12 days. Lymphocyte proliferative responses were determined using 3H-TdR uptakes and interferon (IFN)-gamma produc...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Main pancreatic duct obstruction due to a small nonfunctioning endocrine tumor of the pancreas.
Authors: Uemura K, Murakami Y, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H, Sasaki T, Arihiro K, Sueda T Abstract A 65-year-old Japanese male was referred to our hospital for evaluation of a main pancreatic duct obstruction. Two months previously, he had suffered an attack of acute pancreatitis that was resolved with conservative treatment. Dynamic contrast-enhanced study by multidetector row computed tomography revealed a well-enhanced 5 x 5 mm mass in the head of the pancreas with dilatation of the main pancreatic duct in the body and tail. On endoscopic retrograde pancreatography, obstruction of the main...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Evaluation of the usefulness of a simple touch-panel method for the screening of dementia.
Authors: Tsuboi K, Harada T, Ishii T, Morishita H, Ohtani H, Ishizaki F Abstract In clinical settings, Hasegawa's dementia scale, revised (HDS-R), and the mini-mental state examination (MMSE) are widely employed as simple mental function tests useful for the diagnosis of dementia. In recent years, for the early diagnosis of dementia, a simple computerized touch panel-type screening test (touch panel-type screening test), called the "forgetfulness consultation program" (Nihon Kohden Corp.), has been developed. We performed dementia screening using this touch panel-type screening test in 95 elderly subjects,...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Ruptured vertebral artery dissecting aneurysms treated with endovascular treatment.
Authors: Shibukawa M, Sakamoto S, Kiura Y, Matsushige T, Kurisu K Abstract Intracranial vertebral artery (VA) dissecting aneurysms often present with severe subarachnoid hemorrhage (SAH) and a subsequent high rate of mortality. We retrospectively studied the treatment efficacy and outcomes of 26 patients with ruptured VA dissecting aneurysms treated with endovascular surgery. Twenty-six patients with ruptured VA dissecting aneurysms were enrolled. Fifteen patients presented with poor-grade SAH and eleven with good-grade SAH. All patients were treated with endovascular treatment. We reviewed modes of therap...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

The prevalence of urinary lithiasis in children in Van Region, Turkey.
In conclusion, we found that was the prevalence of urinary lithiasis was 1.7% in school-aged children in our region. It was also noted that all urinary lithiasis was in the upper urinary system and its most common cause was metabolic disorder. PMID: 20027811 [PubMed - indexed for MEDLINE] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

Blood transport method for chromosome analysis of residents living near Semipalatinsk nuclear test site.
Authors: Rodzi M, Ihda S, Yokozeki M, Takeichi N, Tanaka K, Hoshi M Abstract A study was conducted to compare the storage conditions and transportation period for blood samples collected from residents living in areas near the Semipalatinsk nuclear test site (SNTS). Experiments were performed to simulate storage and shipping environments. Phytohaemagglutinin (PHA)-stimulated blood was stored in 15-ml tubes (condition A: current transport method) in the absence or in 50-ml flasks (condition B: previous transport method) in the presence of RPMI-1640 and 20% fetal bovine serum (FBS). Samples were kept refrige...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research