Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field—but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly informed drugs in oncology, we here discuss what it may take to bring molecularly targeted anti-fibrotic to clinical use in chronic progressive kidney disease. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - September 1, 2015 Category: Biomedical Science Authors: Michael ZeisbergElisabeth Zeisberg Source Type: research
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling
Conclusions:
Although further studies are required, we provide evidence that cytoglobin is a negative regulator of stellate cell activation and therefore may represent a novel target for anti-fibrotic treatments in the future. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - August 21, 2015 Category: Biomedical Science Authors: Louise StoneLorna ThorneChristopher WestonMark GrahamNikolas Hodges Source Type: research
In vitro reversion of activated primary human hepatic stellate cells
Conclusions:
We provide evidence for the ability of human primary aHSCs to revert in vitro to a transitional state through synergistic action of EGF, FGF2, dietary fatty acids and retinol, and provide a first phenotypic and genomic characterization of human in vitro rHSCs. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - August 6, 2015 Category: Biomedical Science Authors: Adil El TaghdouiniMustapha NajimiPau Sancho-BruEtienne SokalLeo van Grunsven Source Type: research
Association of circulating angiogenesis inhibitors and asymmetric dimethyl arginine with coronary plaque burden
Conclusions:
Our findings suggest that associations of circulating END, ENG, TSP, and ANG with cardiovascular mortality are unlikely to be mediated via direct effects on coronary plaque formation or by inhibition of collateral formation. Whether associations of these factors with mortality are mediated via local concentrations, myocardial tissue, or intra-plaque expression of these factors or by an effect on plaque vulnerability merits additional investigation. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - July 21, 2015 Category: Biomedical Science Authors: David CharytanAngeles CinelliElisabeth Zeisberg Source Type: research
Novel approach for the detection of tubular cell migration into the interstitium during renal fibrosis in rats
Conclusions:
Long-term BrdU labeling marked some of the proximal tubular cells and enabled us to detect tubular cell migration into the interstitium after UUO. This simple method might be useful to detect EMT in vivo. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - July 10, 2015 Category: Biomedical Science Authors: Masao NakasatomiAkito MaeshimaKeiichiro MishimaHidekazu IkeuchiToru SakairiYoriaki KanekoKeiju HiromuraYoshihisa Nojima Source Type: research
Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1
Conclusions:
To the best of our knowledge, this is the first report that the expression and function of CCR1, CCR2, and CCR3 are upregulated in monocytes from healthy AA and from SSc patients via molecular mechanisms involving caveolin-1, Src/Lyn, and MEK/ERK. The results suggest that the migration/recruitment of monocytes and fibrocytes into fibrotic tissues, mediated at least in part by CCR1, CCR2, and CCR3, plays a major role in the progression of lung and skin fibrosis and in the predisposition of AA to fibrotic diseases. Our findings further suggest that chemokine receptors and signaling molecules, particularly caveol...
Source: Fibrogenesis and Tissue Repair - June 20, 2015 Category: Biomedical Science Authors: Rebecca LeeCharles ReeseBeth PerryJonathan HeywoodMichael BonnerMarina ZemskovaRichard SilverStanley HoffmanElena Tourkina Source Type: research
Pentoxifylline immunomodulation in the treatment of experimental chronic pulmonary paracoccidioidomycosis
Background:
Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties. The simultaneous use of PTX and antifungal therapy (itraconazole) has previously been evaluated in an experimental model of pulmonary paracoccidioidomycosis (PCM), a systemic fungal disease caused by the fungus Paracoccidioides brasiliensis (Pb) and characterized by chronic inflammation and lung fibrosis that appears even after a successful course of antifungal therapy. The results revealed prompt and statistically significant reductions in inflammation and fibrosis when compared to itraconazole alone. However, ...
Source: Fibrogenesis and Tissue Repair - June 1, 2015 Category: Biomedical Science Authors: Damaris LoperaTonny NaranjoJosé HidalgoLaura EcheverriJairo PatiñoÁngela MorenoHenrique LenziLuz Cano Source Type: research
Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration
Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the symptoms of many human diseases have been reversed in animal models with iPSC therapy, setting the stage for future clinical development. From the animal data it is clear that iPSC are rapidly becoming the lead cell type for cell replacement therapy and for the newly developing field of iPSC-derived body organ transplantation. The first human pathology that might be treated in the near future with iPSC is age-related macular degeneration (AMD), which has recently passed the criteria set down by regulators for phase I clinical trials with allogeneic h...
Source: Fibrogenesis and Tissue Repair - May 15, 2015 Category: Biomedical Science Authors: Ana Alvarez PalomoSamuel McLenachanFred ChenLyndon Da CruzRodney DilleyJordi RequenaMichaela LucasAndrew LucasMicha DrukkerMichael Edel Source Type: research
Donor caveolin 1 (CAV1) genetic polymorphism influences graft function after renal transplantation
Conclusions:
Genotyping of CAV1 may be relevant to identify patients at risk of adverse renal transplant outcome. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - May 5, 2015 Category: Biomedical Science Authors: Cynthia Van der HauwaertGrégoire SavaryClaire PinçonViviane GnemmiChristian NoëlFranck BrolyMyriam LabaletteMichaël PerraisNicolas PottierFrançois GlowackiChristelle Cauffiez Source Type: research
Modulation of angiotensin II signaling in the prevention of fibrosis
This article reviews current knowledge on the role that angiotensin II plays in tissue fibrosis, as well as current and potential therapies targeting this system. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 23, 2015 Category: Biomedical Science Authors: Amanda MurphyAlison WongMichael Bezuhly Source Type: research
Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney
Conclusions:
We provide evidence that in the context of renal injury, primary cilia act as molecular switches between canonical and non-canonical Wnt signaling activity, possibly determining between regenerative and pro-fibrotic effects of Wnt re-expression in the injured kidney. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 16, 2015 Category: Biomedical Science Authors: Shoji SaitoBjörn TampeGerhard MüllerMichael Zeisberg Source Type: research
Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca2+-dependent and regulated by KCa3.1 K+ channels
Conclusions:
KCa3.1 activity regulates TGFβ1-dependent effects in NFC- and IPF-derived primary HLMFs through the regulation of the TGFβ1/Smad signalling pathway, with promotion of downstream gene transcription and protein expression. KCa3.1 blockers may offer a novel approach to treating IPF. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - March 26, 2015 Category: Biomedical Science Authors: Katy RoachCarol Feghali-BostwickHeike WulffYassine AmraniPeter Bradding Source Type: research
Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism
No description available (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - March 14, 2015 Category: Biomedical Science Authors: Yunliang ChenAndrew LeaskDavid AbrahamLaura KennedyXu Shi-wenChristopher DentonCarol BlackLiaquat VerjeeMark Eastwood Source Type: research
Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
Biological markers, i.e., biomarkers, in lung tissue may make it possible to connect cell biological phenomena to the pathogenetic mechanisms in idiopathic pulmonary fibrosis (IPF). This review focuses on the lung tissue biomarkers, which have been compared with relevant clinical endpoints or with the most common differential diagnostic lung diseases. In addition, studies conducted on lung tissue samples and investigated by transcriptomic or proteomic methodologies have been included. Several studies have observed changes in alveolar epithelium and extracellular matrix supporting the current hypotheses of the pathogenesis ...
Source: Fibrogenesis and Tissue Repair - March 2, 2015 Category: Biomedical Science Authors: Riitta KaarteenahoElisa Lappi-Blanco Source Type: research
Workshop on cardiovascular extracellular matrix in health and disease in Baeza, Spain
The Workshop on Cardiovascular Extracellular Matrix in Health and Disease, International University of Andalusia, Baeza, Spain, 6-8 October 2014 served to discuss the current knowledge on the mechanisms integral to extracellular matrix homeostasis that are fundamental to understanding the pathological basis of several cardiovascular diseases, including the development of cardiac fibrosis in response to cardiac hypertrophy and myocardial infarction, and the extracellular matrix alterations contributing to aortic stenosis or aneurysms. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - February 2, 2015 Category: Biomedical Science Authors: Enrique Lara-PezziElke DworatzekFernando Rodríguez-Pascual Source Type: research
