Active transforming growth factor- β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis
Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows the tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can ... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 27, 2016 Category: Biomedical Science Authors: Robert M. DiFazio, Joshua T. Mattila, Edwin C. Klein, Lauren R. Cirrincione, Mondraya Howard, Eileen A. Wong and JoAnne L. Flynn Source Type: research
Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis
Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows the tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can ... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 27, 2016 Category: Biomedical Science Authors: Robert M. DiFazio, Joshua T. Mattila, Edwin C. Klein, Lauren R. Cirrincione, Mondraya Howard, Eileen A. Wong and JoAnne L. Flynn Source Type: research
Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice
Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation an... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - March 31, 2016 Category: Biomedical Science Authors: Jennifer M. McCracken, Lu Jiang, Krutika T. Deshpande, Maura F. O’Neil and Michele T. Pritchard Source Type: research
Biomaterials for hollow organ tissue engineering
Tissue engineering is a rapidly advancing field that is likely to transform how medicine is practised in the near future. For hollow organs such as those found in the cardiovascular and respiratory systems or ... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - March 23, 2016 Category: Biomedical Science Authors: Eseelle K. Hendow, Pauline Guhmann, Bernice Wright, Panagiotis Sofokleous, Nina Parmar and Richard M. Day Source Type: research
Transcriptomic analysis of the effects of Toll-like receptor 4 and its ligands on the gene expression network of hepatic stellate cells
Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of TLR4 signaling on the gene expression net... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - February 18, 2016 Category: Biomedical Science Authors: Yangyang Ouyang, Jinsheng Guo, Chenzhao Lin, Jie Lin, Yirong Cao, Yuanqin Zhang, Yujin Wu, Shiyao Chen, Jiyao Wang, Luonan Chen and Scott L. Friedman Source Type: research
Dipeptidyl peptidase-4 and kidney fibrosis in diabetes
Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Recent eviden... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - February 13, 2016 Category: Biomedical Science Authors: Sen Shi, Daisuke Koya and Keizo Kanasaki Source Type: research
Thromboxane promotes smooth muscle phenotype commitment but not remodeling of hypoxic neonatal pulmonary artery
Persistent pulmonary hypertension of the newborn (PPHN) is characterized by vasoconstriction and pulmonary vascular remodeling. Remodeling is believed to be a response to physical or chemical stimuli including... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - November 1, 2015 Category: Biomedical Science Authors: Fabiana Postolow, Jena Fediuk, Nora Nolette, Martha Hinton and Shyamala Dakshinamurti Source Type: research
Thromboxane promotes smooth muscle phenotype commitment but not remodeling of hypoxic neonatal pulmonary artery
Conclusions:
We conclude that thromboxane does not initiate phenotypic dedifferentiation and proliferative activation in PPHN PA. Exposure to thromboxane triggers cell cycle exit and myocyte commitment to contractile phenotype. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - November 1, 2015 Category: Biomedical Science Authors: Fabiana PostolowJena FediukNora NoletteMartha HintonShyamala Dakshinamurti Source Type: research
Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury
Macrophages play critical roles in liver regeneration, fibrosis development and resolution. They are among the first responders to liver injury and are implicated in orchestrating the fibrogenic response via m... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - October 15, 2015 Category: Biomedical Science Authors: Katharine M. Irvine, Andrew D. Clouston, Victoria L. Gadd, Gregory C. Miller, Weng-Yew Wong, Michelle Melino, Muralidhara Rao Maradana, Kelli MacDonald, Richard A. Lang, Matthew J. Sweet, Antje Blumenthal and Elizabeth E. Powell Source Type: research
Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury
Conclusion:
In summary, these data suggest that macrophage-derived Wnt proteins possess anti-fibrogenic potential in chronic liver disease, which may be able to be manipulated for therapeutic benefit. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - October 15, 2015 Category: Biomedical Science Authors: Katharine IrvineAndrew CloustonVictoria GaddGregory MillerWeng-Yew WongMichelle MelinoMuralidhara MaradanaKelli MacDonaldRichard LangMatthew SweetAntje BlumenthalElizabeth Powell Source Type: research
Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis
Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular matrix proteins such as collagens and fibronectin, f... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - October 1, 2015 Category: Biomedical Science Authors: Roisin Neary, Chris J. Watson and John A. Baugh Source Type: research
Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis
Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular matrix proteins such as collagens and fibronectin, fibrosis affects normal tissue architecture and impedes organ function. Although a considerable amount of research has focused on the mechanisms underlying disease pathogenesis, current therapeutic options do not directly target the pro-fibrotic process. As a result, there is a clear unmet clinical need to develop new agents. Novel findings implicate a role for epigenetic modifications contributing to the progression o...
Source: Fibrogenesis and Tissue Repair - October 1, 2015 Category: Biomedical Science Authors: Roisin NearyChris WatsonJohn Baugh Source Type: research
L
59
TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
Conclusions:
L
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LAP-DPs reflect PLK-dependent TGF-β activation and the increase in αSMA-positive activated HSCs in liver injury, thereby serving as a novel blood biomarker for liver fibrogenesis. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - September 15, 2015 Category: Biomedical Science Authors: Mitsuko HaraIkuyo InoueYuta YamazakiAkiko KiritaTomokazu MatsuuraScott FriedmanDaniel RifkinSoichi Kojima Source Type: research
L 59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
Conclusions:
L
59
LAP-DPs reflect PLK-dependent TGF-β activation and the increase in αSMA-positive activated HSCs in liver injury, thereby serving as a novel blood biomarker for liver fibrogenesis. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - September 15, 2015 Category: Biomedical Science Authors: Mitsuko HaraIkuyo InoueYuta YamazakiAkiko KiritaTomokazu MatsuuraScott FriedmanDaniel RifkinSoichi Kojima Source Type: research
