Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Conclusion:
In summary, these data suggest that macrophage-derived Wnt proteins possess anti-fibrogenic potential in chronic liver disease, which may be able to be manipulated for therapeutic benefit.

Source: Fibrogenesis and Tissue Repair - October 15, 2015 Category: Biomedical Science Authors: Katharine IrvineAndrew CloustonVictoria GaddGregory MillerWeng-Yew WongMichelle MelinoMuralidhara MaradanaKelli MacDonaldRichard LangMatthew SweetAntje BlumenthalElizabeth Powell Source Type: research