Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing ¿ a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites
Conclusion:
The results demonstrate the positive contribution of autologous platelets combined with keratinocytes in stimulating wound healing and reducing pain. This strikingly simple approach could have a significant impact on patient care, especially critically burned victims for whom time is of the essence.Clinical trial registry information: Protocol Record Identification Number: 132/03Registry URL: http://www.clinicaltrials.gov (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 9, 2013 Category: Biomedical Science Authors: Samia GueridSalim DarwicheMette BergerLee Ann ApplegateMessod BenathanWassim Raffoul Source Type: research
Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing -- a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites
Conclusion:
The results demonstrate the positive contribution of autologous platelets combined with keratinocytes in stimulating wound healing and reducing pain. This strikingly simple approach could have a significant impact on patient care, especially critically burned victims for whom time is of the essence.Clinical trial registry information: Protocol Record Identification Number: 132/03Registry URL: http://www.clinicaltrials.gov (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 9, 2013 Category: Biomedical Science Authors: Samia GueridSalim DarwicheMette BergerMessod BenathanWassim Raffoul Source Type: research
Cyclosporin A reduces matrix metalloproteinases and collagen expression in dermal fibroblasts from regenerative FOXN1 deficient (nude) mice
Conclusion:
The data suggest that by alternation of the accumulation of extracellular matrix components CsA treatment stimulates the transition from a scarless to a scar healing. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 2, 2013 Category: Biomedical Science Authors: Barbara Gawronska-KozakHeather Kirk-Ballard Source Type: research
Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-ß and is required for TGF-ß-induced hydrogen peroxide production in fibroblasts
Conclusions:
The results presented in this study suggest that SPARC plays a role in epithelial damage in the IPF lung via enhanced H2O2 production from fibroblasts activated by TGF-β. Therefore, SPARC inhibition may prevent epithelial injury in IPF lung and represent a potential therapeutic approach for IPF. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - March 21, 2013 Category: Biomedical Science Authors: Saiko ShibataJunichi Ishiyama Source Type: research
Function and fate of myofibroblasts after myocardial infarction
The importance of cardiac fibroblasts in the regulation of myocardial remodelling following myocardial infarction (MI) is becoming increasingly recognised. Studies over the last few decades have reinforced the concept that cardiac fibroblasts are much more than simple homeostatic regulators of extracellular matrix turnover, but are integrally involved in all aspects of the repair and remodelling of the heart that occurs following MI. The plasticity of fibroblasts is due in part to their ability to undergo differentiation into myofibroblasts. Myofibroblasts are specialised cells that possess a more contractile and synthetic...
Source: Fibrogenesis and Tissue Repair - March 1, 2013 Category: Biomedical Science Authors: Neil TurnerKaren Porter Source Type: research
Comparison of acute proton, photon, and low-dose priming effects on genes associated with extracellular matrix and adhesion molecules in the lungs
Conclusion:
These data show that marked differences were present between acutely delivered protons and photons in modulating genes, and the effect of protons was more profound than that of photons. Pre-exposure to LDR gamma-rays 'normalized' some genes that were modified by acute irradiation. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - February 4, 2013 Category: Biomedical Science Authors: Jian TianSisi TianDaila Gridley Source Type: research
Serum amyloid P inhibits granulocyte adhesion
Conclusions:
We found that SAP, a constitutive component of blood, is a granulocyte adhesion inhibitor. We hypothesize that SAP allows granulocytes to sense whether they are in the blood or in a tissue. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - January 17, 2013 Category: Biomedical Science Authors: Anu MaharjanDavid RoifeDerrick BrazillRichard Gomer Source Type: research
HDAC inhibitors in experimental liver and kidney fibrosis
Histone deacetylase (HDAC) inhibitors have been extensively studied in experimental models of cancer, where their inhibition of deacetylation has been proven to regulate cell survival, proliferation, differentiation and apoptosis. This in turn has led to the use of a variety of HDAC inhibitors in clinical trials. In recent years the applicability of HDAC inhibitors in other areas of disease has been explored, including the treatment of fibrotic disorders. Impaired wound healing involves the continuous deposition and cross-linking of extracellular matrix governed by myofibroblasts leading to diseases such as liver and kidne...
Source: Fibrogenesis and Tissue Repair - January 2, 2013 Category: Biomedical Science Authors: Katrien Van BenedenInge MannaertsMarina PauwelsChristiane Van den BrandenLeo van Grunsven Source Type: research
Origin of myofibroblasts in liver fibrosis
Most chronic liver diseases of all etiologies result in progressive liver fibrosis. Myofibroblasts produce the extracellular matrix, including type I collagen, which constitutes the fibrous scar in liver fibro... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - June 6, 2012 Category: Biomedical Science Authors: David A Brenner, Tatiana Kisseleva, David Scholten, Yong Han Paik, Keiko Iwaisako, Sayaka Inokuchi, Bernd Schnabl, Ekihiro Seki, Samuele De Minicis, Christoph Oesterreicher and Kojiro Taura Source Type: research
From biochemical analysis to targeted therapies
(Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - June 6, 2012 Category: Biomedical Science Authors: Petro E Petrides and David Brenner Source Type: research
CCR6 is not necessary for functional effects of human CCL18 in a mouse model
CCL18, a chemokine with no known receptor, has been implicated in several fibrotic pulmonary diseases associated with T-lymphocyte infiltration. It has been hypothesized that CCL18 may act through CCR6. Gene d... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - January 18, 2012 Category: Biomedical Science Authors: Irina G Luzina and Sergei P Atamas Source Type: research
Centrilobular emphysema combined with pulmonary fibrosis results in improved survival: a response
Better survival in combined pulmonary fibrosis and emphysema than in lone pulmonary fibrosis: bias or reality? A response to Centrilobular emphysema combined with pulmonary fibrosis results in improved surviva... (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - July 25, 2011 Category: Biomedical Science Authors: Vincent Cottin, Jean-François Cordier and Athol U Wells Source Type: research
Welcome to Fibrogenesis & Tissue Repair
(Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Massimo Pinzani Source Type: research
