Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-ß and is required for TGF-ß-induced hydrogen peroxide production in fibroblasts

Conclusions: The results presented in this study suggest that SPARC plays a role in epithelial damage in the IPF lung via enhanced H2O2 production from fibroblasts activated by TGF-β. Therefore, SPARC inhibition may prevent epithelial injury in IPF lung and represent a potential therapeutic approach for IPF.
Source: Fibrogenesis and Tissue Repair - Category: Biomedical Science Authors: Source Type: research