Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney
Conclusions:
We provide evidence that in the context of renal injury, primary cilia act as molecular switches between canonical and non-canonical Wnt signaling activity, possibly determining between regenerative and pro-fibrotic effects of Wnt re-expression in the injured kidney.
Source: Fibrogenesis and Tissue Repair - Category: Biomedical Science Authors: Shoji SaitoBjörn TampeGerhard MüllerMichael Zeisberg Source Type: research