Association of circulating angiogenesis inhibitors and asymmetric dimethyl arginine with coronary plaque burden

Conclusions:
Our findings suggest that associations of circulating END, ENG, TSP, and ANG with cardiovascular mortality are unlikely to be mediated via direct effects on coronary plaque formation or by inhibition of collateral formation. Whether associations of these factors with mortality are mediated via local concentrations, myocardial tissue, or intra-plaque expression of these factors or by an effect on plaque vulnerability merits additional investigation.

Source: Fibrogenesis and Tissue Repair - July 21, 2015 Category: Biomedical Science Authors: David CharytanAngeles CinelliElisabeth Zeisberg Source Type: research