Heart failure: an historical perspective
The story of heart failure (HF) traces a path from the oldest records of human healing practices several millennia ago, winding through various changing models of physiology, sickness and health. It passes through today’s landscape of neurohormonal modulation, device therapy, and assist devices, towards a future of therapies, some in development today, some as-yet unimagined, based on pathophysiological insights yet to come. This review attempts to follow the path and notes the traces left by earlier travellers, as well as the therapeutic improvements made possible by the developments in our understanding of HF that ...
Source: European Journal of Heart Failure Supplements - December 5, 2016 Category: Cardiology Authors: Ferrari, R., Balla, C., Fucili, A. Tags: Articles Source Type: research

The need to improve acute heart failure treatment
(Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - December 5, 2016 Category: Cardiology Authors: Ferrari, R. Tags: Articles Source Type: research

Relation between serum calcium levels and mortality in patients with coronary artery disease
Conclusions As a widely available clinical index, serum calcium was an independent predictor of both in-hospital and long-term mortality among CAD patients. Further studies are warranted to determine mechanisms and whether patients with hypocalcaemia could benefit from calcium supplement. (Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Yan, S.-d., Peng, Y., Liu, W., Xia, T.-l., Huang, F.-y., Chai, H., Huang, D.-j., Liu, X.-j., Chen, M. Tags: Articles Source Type: research

Water-soluble chitosan regulates vascular remodeling in hypertension via NFATc1
Conclusion In both cell and animal experiments, we succefully confirmed the regulatory effects of WSC on vascular remodeling in hypertension. Based on the present results, WSC-inhibited vascular remodeling may be related to the modulation on NFATc1 expression. Our experiment provides a solid basis for the clinical application of WSC on hypertension. (Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Du, M., Kou, L., Li, S. Tags: Articles Source Type: research

Relationship between Serum fibroblast growth factor 21 levels and morphological atherosclerotic plaque characteristics in patients with coronary heart disease
Conclusion Serum FGF21 is positively correlated with atherosclerotic plaque burden, and interestingly, the high level of serum FGF21 may represent a positive response to atherosclerosis. (Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Wang, X., Huang, X., Hou, J. Tags: Articles Source Type: research

Relationship between serum angiopoietin-like protein 2 and plaque vulnerability in patients with coronary artery disease and diabetes
Conclusion Serum ANGPTL2 level is significantly associated with plaque vulnerability in patients with CAD and diabetes. Systemic ANGPTL2 comprises an inflammatory adipokine that links the adipose tissue and coronary plaque. (Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Xie, Z., Liu, X., Tian, J., Yin, L., Yu, B. Tags: Articles Source Type: research

A case of acute myocardial infarction after successful transcatheter closure of ventricular septal defect
Congenital heart diseases can be treated without surgery through advances in interventional cardiology. Complications such as infection and thrombus formation may develop due to foreign materials used during these procedures. Paradoxical embolism is a rare complication of transcatheter closure of ventricular septal defect (VSD) and could be responsible for acute myocardial infarction. Herein, we present a case of coronary thrombosis in a 2-year-old patient with VSD, which was closed with the Amplatzer VSD device. Although extremely rare, it should be considered in the appropriate clinical setting. (Source: European Journal...
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Xianglan, L., Jian, W., Xia, G., Di, C., Jingyi, Z., Bo, Z., Bo, Y., Yong, S. Tags: Articles Source Type: research

A case of 10 year follow-up after transcatheter closure of a traumatic ventricular septal defect
Ventricular septal defect (VSD) is an uncommon complication of penetrating heart injuries, but transcatheter closure has emerged as a new technique and is widely used worldwide. In spite of high success rate and minimal operative mortality, short-term follow-up post-operation and long-term follow-up post-operation have not been observed. In the present study, we report a case of cardiac injury after stabbing himself with a dagger. The patient was diagnosed with a post-traumatic VSD with left-to-right shunt and was transferred to theatre where the defect was successfully repaired. Seven days later, on echocardiography exami...
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Chi, D., Sun, Y., Tan, M., Zheng, Y., Liu, X., Yu, B., Wu, J. Tags: Articles Source Type: research

Switching between ticagrelor and clopidogrel in patients who underwent percutaneous coronary intervention: insight into contemporary practice in Chinese patients
Ticagrelor has been proved to be more effective than clopidogrel; however, little is known about the switching between ticagrelor and clopidogrel in real-world clinical practice. We assessed the prevalence, related factors, dose bridging, compliance, and short-term outcomes of in-hospital switching between ticagrelor and clopidogrel in consecutively recruited patients treated by ticagrelor after percutaneous coronary intervention (PCI). A total of 417 eligible patients administrated with ticagrelor in-hospital after PCI were recruited. Switching between ticagrelor and clopidogrel occurred in 362 (86.8%) patients, with 318 ...
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Wang, X., Xi, S., Liu, J., Qin, L., Jing, J., Yin, T., Chen, Y. Tags: Articles Source Type: research

Comparison of effectiveness of right ventricular mid-septal pacing vs. apical pacing: a randomized-controlled trials
The aim of the present study was to compare conventional right ventricular apical pacing (RVAP) with right ventricular mid-septal pacing (RVMSP) in terms of echocardiographic and clinical/biologic features. Ninety-six patients with high-degree atrioventricular block were randomly allocated to RVMSP (n = 50) and RVAP (n = 46). Threshold and impedance, echocardiographic left ventricular ejection fraction, ventricular dyssynchrony features, and distance during a 6-min walk test and Minnesota Living with Heart Failure Questionnaire were determined at 6 and 12 months after pacemaker implantation. Serum levels of N-terminal pro-...
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Bai, M., Li, Q., Jiang, G., Zhang, L., Wang, T., Zhang, Z. Tags: Articles Source Type: research

Outline of the report on cardiovascular diseases in China, 2014
We present an abstract from the Report on Cardiovascular Diseases in China (2014), including trends in CVD, morbidity and mortality of major CVD, up-to-date assessment of risk factors, as well as health resources for CVD, and a profile of medical expenditure, with the aim of providing evidence for decision making in CVD prevention and control programmes in China, and of delivering the most authoritative information on CVD prevention and control for all citizens. (Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Weiwei, C., Runlin, G., Lisheng, L., Manlu, Z., Wen, W., Yongjun, W., Zhaosu, W., Huijun, L., Zhe, Z., Lixin, J., Shengshou, H., for the editorial Board, for the editorial Board, Weiwei, Xiaohan, Runlin, Zhan, Dongfeng, Jianguo, Shengshou, Lixin, Guangwei Tags: Articles Source Type: research

Introduction to the Asian Society of Cardiology
(Source: European Journal of Heart Failure Supplements)
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Huo, Y. Tags: Articles Source Type: research

Transcatheter aortic valve replacement--state of the art and a glimpse to the future: 'the Tailored Approach
Transcatheter aortic valve replacement determined a paradigm shift in the treatment of high-risk patients with severe symptomatic aortic valve stenosis. Notwithstanding the impressive results of the first-generation prostheses, a fast-paced technological evolution is taking place to overcome their limitations, in particular the vascular access damage and the paravalvular leak. Nowadays, with the availability of several different devices, the expert operator can select the right prosthesis for the specific anatomical and clinical situation. As ‘One does not fit all’, the ‘Tailored TAVR Approach’ we d...
Source: European Journal of Heart Failure Supplements - April 28, 2016 Category: Cardiology Authors: Bedogni, F., Frigiola, A., Ranucci, M., Brambilla, N., Montone, R. A., Agnifili, M., Menicanti, L., Testa, L. Tags: Articles Source Type: research

Modern ECMO: why an ECMO programme in a tertiary care hospital
Extracorporeal Membrane Oxygenation (ECMO) represents a useful tool to support the lungs and the heart when all conventional therapies failed and the patients are at risk of death. While the Extracorporeal Life Support Organization (ELSO) collects data from different institutions that joined the Registry and reports overall outcome, individual centres often collide with results below expectations, either in adults and in paediatric population. Some authors suggest that poor outcomes could be overcome with a programme dedicated to ECMO, with specialized professionals adequately trained on ECMO and with a consistent number o...
Source: European Journal of Heart Failure Supplements - April 28, 2016 Category: Cardiology Authors: Cotza, M., Carboni, G., Ballotta, A., Kandil, H., Isgro, G., Carlucci, C., Varrica, A., Garatti, A., Giamberti, A., Ranucci, M., for the Surgical and Clinical Outcome Research (SCORE) Group and for the PSD ECMO Team Tags: Articles Source Type: research

International cooperation in healthcare: model of IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association for congenital heart diseases
Cooperation activity in training programmes promoted by IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association is a model of cooperation between people as an alternative intervention in promoting the right to healthcare, especially offering programmes of training and medical care on cardiovascular and congenital heart disease. This new strategy, implemented in several developing countries, has absolutely contributed to the improvement of the medical services concerning the diagnostic and surgical approach in the treatment of paediatric and adult cardiovascular disease. To strengthen this kind of activi...
Source: European Journal of Heart Failure Supplements - April 28, 2016 Category: Cardiology Authors: Frigiola, A., Moussaidi, N., Giamberti, A., Pome, G., Isgro, G., Youssef, T., Reali, M., Varrica, A., Nuri, H. A., Cirri, S., Carminati, M., Menicanti, L., Ferrari, R., Ranucci, M. Tags: Articles Source Type: research