Mesenteric fibrosis and palliative surgery in small intestinal neuroendocrine tumours
In conclusion, we confirmed known predictors of MF and mesenteric mass and suggest a role for sex hormones as women ≤52 years have less often a mesenteric mass. Furthermore, the presence of MF has no effect on survival in a multivariate analysis, and we found no benefit of metastasectomy of mesenteric mass or prophylactic surgery on overall survival. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Blažević, A., Zandee, W. T., Franssen, G. J. H., Hofland, J., van Velthuysen, M.-L. F., Hofland, L. J., Feelders, R. A., de Herder, W. W. Tags: Research Source Type: research
The microbiome in PTEN hamartoma tumor syndrome
Germline PTEN mutations defining PTEN hamartoma tumor syndrome (PHTS) confer heritable predisposition to breast, endometrial, thyroid and other cancers with known age-related risks, but it remains impossible to predict if any individual will develop cancer. In the general population, gut microbial dysbiosis has been linked to cancer, yet is unclear whether these are associated in PHTS patients. In this pilot study, we aimed to characterize microbial composition of stool, urine, and oral wash from 32 PTEN mutation-positive individuals using 16S rRNA gene sequencing. PCoA revealed clustering of the fecal microbiome by cancer...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Byrd, V., Getz, T., Padmanabhan, R., Arora, H., Eng, C. Tags: Research Source Type: research
Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients
This study aimed to identify circulating miRNAs as novel non-invasive biomarkers for prognosis and vandetanib response in advanced medullary thyroid cancer (MTC) patients. We prospectively recruited two independent cohorts of locally advanced/metastatic MTC patients including a subgroup of vandetanib-treated subjects: a discovery cohort (n = 20), including matched plasma/tissue samples (n = 17/20), and a validation cohort, yielding only plasma samples (n = 17). Plasma samples from healthy subjects (n = 36) and MTC patients in remission (n = 9) were used as controls. MTC (n = 17 from 8 patients included in discovery cohort)...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Romeo, P., Colombo, C., Granata, R., Calareso, G., Gualeni, A. V., Dugo, M., De Cecco, L., Rizzetti, M. G., Zanframundo, A., Aiello, A., Carcangiu, M. L., Gloghini, A., Ferrero, S., Licitra, L., Greco, A., Fugazzola, L., Locati, L. D., Borrello, M. G. Tags: Research Source Type: research
Receptor activities of persistent pollutant serum mixtures and breast cancer risk
Studies on associations between persistent organic pollutants (POPs) and breast cancer risk are inconclusive. The majority of studies have evaluated the effect of single compounds, without considering multiple exposures to and interactions between different POPs. The present study aimed at evaluating breast cancer risk related to combined effects of serum POP mixtures on cellular receptor functions. Data on breast cancer cases (n = 77) and controls (n = 84) were collected among Greenlandic Inuit women. Serum mixtures of lipophilic POPs (lipPOPs), perfluoroalkyl acids (PFAAs) and dioxin-like POPs were extracted. The effect ...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Wielsoe, M., Bjerregaard-Olesen, C., Kern, P., Bonefeld-Jorgensen, E. C. Tags: Research Source Type: research
Genetic testing for indeterminate thyroid cytology: review and meta-analysis
Thyroid cancer is the most frequent endocrine malignancy, and its incidence is increasing. A current limitation of cytological evaluation of thyroid nodules is that 20–25% are reported as indeterminate. Therefore, an important challenge for clinicians is to determine whether an indeterminate nodule is malignant, and should undergo surgery, or benign, and should be recommended to follow-up. The emergence of precision medicine has offered a valuable solution for this problem, with four tests currently available for the molecular diagnosis of indeterminate cytologies. However, efforts to critically analyze the quality o...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Vargas-Salas, S., Martinez, J. R., Urra, S., Dominguez, J. M., Mena, N., Uslar, T., Lagos, M., Henriquez, M., Gonzalez, H. E. Tags: Review Source Type: research
Anaplastic thyroid carcinoma: review of treatment protocols
Anaplastic thyroid carcinoma (ATC) is an orphan disease and in most patients fatal. So far no established treatment is available that prolongs survival. Several large retrospective studies have identified negative prognostic markers, analyzed efficacy of multimodal approaches such as radiotherapy with and without concurrent chemotherapy and chemotherapy protocols. Recently, single case reports have suggested some effectiveness of newer therapies targeting single somatic alterations in ATC. Overall, the conclusions that can be drawn from published retrospective studies and the scarce prospective approaches is that new treat...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Tiedje, V., Stuschke, M., Weber, F., Dralle, H., Moss, L., Fuhrer, D. Tags: Review Source Type: research
Genetics of tumors of the adrenal cortex
This review describes the molecular alterations observed in the various types of tumors of the adrenal cortex, excluding Conn adenomas, especially the alterations identified by genomic approaches these last five years. Two main forms of bilateral adrenocortical tumors can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenal disease (PPNAD), which can be sporadic or part of Carney complex and primary bilateral macro nodular adrenal hyperplasia (PBMAH). The bilateral nature of the tumors suggests the existence of an underlying genetic predisposition. PPNAD and Carney complex are mai...
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Bonnet-Serrano, F., Bertherat, J. Tags: Review Source Type: research
Towards optimal personalized diet and vitamin supplementation in NET patients
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: de Hosson, L. D., Stelwagen, J., Bouma, G., Sijtema, B., Huitema, S., van Faassen, H. J. R., de Bock, G. H., de Groot, D. J. A., Campmans-Kuijpers, M. J. E., Kema, I. P., de Vries, E. G. E., Walenkamp, A. M. E. Tags: Research Letter Source Type: research
Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Lutz, S. Z., Todenhofer, T., Wagner, R., Hennenlotter, J., Ferchl, J. M., Scharpf, M. O., Martus, P., Staiger, H., Fritsche, A., Stenzl, A., Haring, H.-U., Heni, M. Tags: Research Letter Source Type: research
Nfe2l1-silenced insulinoma cells acquire aggressiveness and chemoresistance
The transcription factor nuclear factor erythroid 2-like 1 (NFE2L1 or NRF1) is involved in various critical cell processes such as maintenance of ubiquitin-proteasome system and regulation of the cellular antioxidant response. We previously determined that pancreatic β-cell-specific Nfe2l1-knockout mice had hyperinsulinemia and that silencing of Nfe2l1 in mouse islets or MIN6 insulinoma β-cells induced elevated basal insulin release and altered glucose metabolism. Hypoglycemia is a major issue with aggressive insulinomas, although a role of NFE2L1 in this pathology is not defined. In the present work, we studied ...
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Fu, J., Zheng, H., Cui, Q., Chen, C., Bao, S., Sun, J., Li, L., Yang, B., Wang, H., Hou, Y., Xu, Y., Xu, Y., Zhang, Q., Pi, J. Tags: Research Source Type: research
Copy number profiling of oncogenes in ductal carcinoma in situ of the male breast
In conclusion, male DCIS and IC showed a similar copy number profile for 21 out of 22 interrogated BC-related genes, illustrating their clonal relation and the genetically advanced state of male DCIS. MTDH showed a higher copy number ratio in IC compared to adjacent and pure DCIS and may therefore play a role in male breast carcinogenesis. Differences were detected between male and female DCIS for 4 genes pointing to differences in breast carcinogenesis between the sexes. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Vermeulen, M. A., Doebar, S. C., van Deurzen, C. H. M., Martens, J. W. M., van Diest, P. J., Moelans, C. B. Tags: Research Source Type: research
The role of the AR/ER ratio in ER-positive breast cancer patients
In conclusion, the AR/ER ratio ≥2 identifies a subgroup of patients with aggressive biological features and may represent an additional independent marker of worse BC prognosis. Moreover, the Prosigna-PAM50 results indicate that a significant number of cases with AR/ER≥2 could be non-luminal tumours. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Rangel, N., Rondon-Lagos, M., Annaratone, L., Osella-Abate, S., Metovic, J., Mano, M. P., Bertero, L., Cassoni, P., Sapino, A., Castellano, I. Tags: Research Source Type: research
Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum
Small intestinal neuroendocrine tumours (SI-NETs) are neoplasms characterized by their ability to secrete biogenic amines and peptides. These cause distinct clinical pathology including carcinoid syndrome, marked by diarrhoea and flushing, as well as fibrosis, notably mesenteric fibrosis. Mesenteric fibrosis often results in significant morbidity by causing intestinal obstruction, oedema and ischaemia. Although advancements have been made to alleviate symptoms of carcinoid syndrome and prolong the survival of patients with SI-NETs, therapeutic options for patients with mesenteric fibrosis are still limited. As improved ins...
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Blažević, A., Hofland, J., Hofland, L. J., Feelders, R. A., de Herder, W. W. Tags: Review Source Type: research
Detection and monitoring of circulating tumor DNA in adrenocortical carcinoma
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Garinet, S., Nectoux, J., Neou, M., Pasmant, E., Jouinot, A., Sibony, M., Orhant, L., Pipoli da Fonseca, J., Perlemoine, K., Bricaire, L., Groussin, L., Soubrane, O., Dousset, B., Libe, R., Letourneur, F., Bertherat, J., Assie, G. Tags: Research Letter Source Type: research
8th edition of the AJCC/TNM staging system of thyroid cancer: what to expect (ITCO#2)
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Lamartina, L., Grani, G., Arvat, E., Nervo, A., Zatelli, M. C., Rossi, R., Puxeddu, E., Morelli, S., Torlontano, M., Massa, M., Bellantone, R., Pontecorvi, A., Montesano, T., Pagano, L., Daniele, L., Fugazzola, L., Ceresini, G., Bruno, R., Rossetto, R., T Tags: Research Letter Source Type: research
