Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk
In conclusion, concurrent HBF dietary and a low-dose BPA exposure during pregnancy increases mammary tumor incidence in offspring, accompanied by alterations in mammary gland development and gene expression, and possibly through epigenetic reprogramming. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Leung, Y.-K., Govindarajah, V., Cheong, A., Veevers, J., Song, D., Gear, R., Zhu, X., Ying, J., Kendler, A., Medvedovic, M., Belcher, S., Ho, S.-M. Tags: Research Source Type: research
Obesity and menopause modify the epigenomic profile of breast cancer
In conclusion, the epigenome of breast tumors is affected by a complex interaction between BMI and menopausal status. The ZNF577 methylation quantification is clearly relevant for the development of novel biomarkers of precision therapy in breast cancer. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Crujeiras, A. B., Diaz-Lagares, A., Stefansson, O. A., Macias-Gonzalez, M., Sandoval, J., Cueva, J., Lopez-Lopez, R., Moran, S., Jonasson, J. G., Tryggvadottir, L., Olafsdottir, E., Tinahones, F. J., Carreira, M. C., Casanueva, F. F., Esteller, M. Tags: Research Source Type: research
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increasing breast cancer growth and metastasis. 27HC levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. Herein, the effect of statins on serum 27HC and tumor-specific C...
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Kimbung, S., Chang, C.-y., Bendahl, P.-O., Dubois, L., Thompson, J. W., McDonnell, D. P., Borgquist, S. Tags: Research Source Type: research
A role for TET2 in parathyroid carcinoma
Primary hyperparathyroidism (pHPT) is rarely caused by parathyroid carcinoma (PC, <1–5% of pHPT cases). The TET proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and inactivation by mutation or epigenetic deregulation of TET1 and TET2 play important roles in various cancers. Recently, we found that 5hmC was severely reduced in all of the analyzed PCs and with deranged expression of TET1 for the majority of PCs. Here, we have examined the expression of the TET2 protein in 15 5hmC-negative PCs from patients who had local invasion or metastases. Cell growth and cell migratory rol...
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Barazeghi, E., Gill, A. J., Sidhu, S., Norlen, O., Dina, R., Palazzo, F. F., Hellman, P., Stalberg, P., Westin, G. Tags: Research Source Type: research
Association of NF-{kappa}B polymorphisms with clinical outcome of non-medullary thyroid carcinoma
In conclusion, genetic variation in NFKBIA, an inhibitor of NF-B signaling, is associated with clinical response to RAI therapy and with increased production of the pro-inflammatory cytokine IL-1β, providing a potential mechanism for the observed clinical associations. These data suggest that NF-B signaling is involved in NMTC pathogenesis and that the inflammatory tumor microenvironment could contribute to RAI resistance. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Plantinga, T. S., Petrulea, M. S., Oosting, M., Joosten, L. A. B., Piciu, D., Smit, J. W., Netea-Maier, R. T., Georgescu, C. E. Tags: Research Source Type: research
SDHA mutated paragangliomas may be at high risk of metastasis
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Tufton, N., Ghelani, R., Srirangalingam, U., Kumar, A. V., Drake, W. M., Iacovazzo, D., Skordilis, K., Berney, D., Al-Mrayat, M., Khoo, B., Akker, S. A. Tags: Research Letter Source Type: research
Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - July 3, 2017 Category: Endocrinology Authors: Woodward, E. L., Biloglav, A., Ravi, N., Yang, M., Ekblad, L., Wennerberg, J., Paulsson, K. Tags: Erratum Source Type: research
Topoisomerase 2{alpha} and thymidylate synthase expression in adrenocortical cancer
Topoisomerase II alpha (TOP2A) and thymidylate synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II–III disease and 38 of them received adjuvant mitotane. Twenty-six patients with metastatic disease received the EDP-M (etoposide, doxorubicin, Adriamycin, cispla...
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Roca, E., Berruti, A., Sbiera, S., Rapa, I., Oneda, E., Sperone, P., Ronchi, C. L., Ferrari, L., Grisanti, S., Germano, A., Zaggia, B., Scagliotti, G. V., Fassnacht, M., Volante, M., Terzolo, M., Papotti, M. Tags: Research Source Type: research
Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk
In conclusion, concurrent HBF dietary and a low-dose BPA exposure during pregnancy increases mammary tumor incidence in offspring, accompanied by alterations in mammary gland development and gene expression, and possibly through epigenetic reprogramming. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Leung, Y.-K., Govindarajah, V., Cheong, A., Veevers, J., Song, D., Gear, R., Zhu, X., Ying, J., Kendler, A., Medvedovic, M., Belcher, S., Ho, S.-M. Tags: Research Source Type: research
Obesity and menopause modify the epigenomic profile of breast cancer
In conclusion, the epigenome of breast tumors is affected by a complex interaction between BMI and menopausal status. The ZNF577 methylation quantification is clearly relevant for the development of novel biomarkers of precision therapy in breast cancer. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Crujeiras, A. B., Diaz-Lagares, A., Stefansson, O. A., Macias-Gonzalez, M., Sandoval, J., Cueva, J., Lopez-Lopez, R., Moran, S., Jonasson, J. G., Tryggvadottir, L., Olafsdottir, E., Tinahones, F. J., Carreira, M. C., Casanueva, F. F., Esteller, M. Tags: Research Source Type: research
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increasing breast cancer growth and metastasis. 27HC levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. Herein, the effect of statins on serum 27HC and tumor-specific C...
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Kimbung, S., Chang, C.-y., Bendahl, P.-O., Dubois, L., Thompson, J. W., McDonnell, D. P., Borgquist, S. Tags: Research Source Type: research
A role for TET2 in parathyroid carcinoma
Primary hyperparathyroidism (pHPT) is rarely caused by parathyroid carcinoma (PC, <1–5% of pHPT cases). The TET proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and inactivation by mutation or epigenetic deregulation of TET1 and TET2 play important roles in various cancers. Recently, we found that 5hmC was severely reduced in all of the analyzed PCs and with deranged expression of TET1 for the majority of PCs. Here, we have examined the expression of the TET2 protein in 15 5hmC-negative PCs from patients who had local invasion or metastases. Cell growth and cell migratory rol...
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Barazeghi, E., Gill, A. J., Sidhu, S., Norlen, O., Dina, R., Palazzo, F. F., Hellman, P., Stalberg, P., Westin, G. Tags: Research Source Type: research
Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - June 22, 2017 Category: Endocrinology Authors: Mathiesen, J. S., Kroustrup, J. P., Vestergaard, P., Madsen, M., Stochholm, K., Poulsen, P. L., Krogh Rasmussen, A., Feldt-Rasmussen, U., Schytte, S., Pedersen, H. B., Hahn, C. H., Bentzen, J., Gaustadnes, M., Orntoft, T. F., Hansen, T. v. O., Nielsen, F. Tags: Research Letter Source Type: research
Topoisomerase 2{alpha} and thymidylate synthase expression in adrenocortical cancer
Topoisomerase II alpha (TOP2A) and thymidylate synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II–III disease and 38 of them received adjuvant mitotane. Twenty-six patients with metastatic disease received the EDP-M (etoposide, doxorubicin, Adriamycin, cispla...
Source: Endocrine-Related Cancer - May 31, 2017 Category: Endocrinology Authors: Roca, E., Berruti, A., Sbiera, S., Rapa, I., Oneda, E., Sperone, P., Ronchi, C. L., Ferrari, L., Grisanti, S., Germano, A., Zaggia, B., Scagliotti, G. V., Fassnacht, M., Volante, M., Terzolo, M., Papotti, M. Tags: Research Source Type: research
Association of NF-{kappa}B polymorphisms with clinical outcome of non-medullary thyroid carcinoma
In conclusion, genetic variation in NFKBIA, an inhibitor of NF-B signaling, is associated with clinical response to RAI therapy and with increased production of the pro-inflammatory cytokine IL-1β, providing a potential mechanism for the observed clinical associations. These data suggest that NF-B signaling is involved in NMTC pathogenesis and that the inflammatory tumor microenvironment could contribute to RAI resistance. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - May 31, 2017 Category: Endocrinology Authors: Plantinga, T. S., Petrulea, M. S., Oosting, M., Joosten, L. A. B., Piciu, D., Smit, J. W., Netea-Maier, R. T., Georgescu, C. E. Tags: Research Source Type: research
