WOMEN IN CANCER THEMATIC REVIEW: Systemic therapies in neuroendocrine tumors and novel approaches toward personalized medicine
Neuroendocrine tumors (NETs) are a group of heterogenous neoplasms. Evidence-based treatment options for antiproliferative therapy include somatostatin analogues, the mTOR inhibitor everolimus, the multiple tyrosine kinase inhibitor sunitinib and peptide receptor radionuclide therapy with 177-Lu-octreotate. In the absence of definite predictive markers, therapeutic decision making follows clinical and pathological criteria. As objective response rates with targeted drugs are rather low, and response duration is limited in most patients, numerous combination therapies targeting multiple pathways have been explored in the fi...
Source: Endocrine-Related Cancer - October 21, 2016 Category: Endocrinology Authors: Pavel, M. E., Sers, C. Tags: Thematic Review Source Type: research
WOMEN IN CANCER THEMATIC REVIEW: Circadian rhythmicity and the influence of 'clock genes on prostate cancer
The androgen receptor (AR) plays a key role in the development and progression of prostate cancer (CaP). Since the mid-1990s, reports in the literature pointed out higher incidences of CaP in some select groups, such as airline pilots and night shift workers in comparison with those working regular hours. The common finding in these ‘high-risk’ groups was that they all experienced a deregulation of the body’s internal circadian rhythm. Here, we discuss how the circadian rhythm affects androgen levels and modulates CaP development and progression. Circadian rhythmicity of androgen production is lost in CaP...
Source: Endocrine-Related Cancer - October 21, 2016 Category: Endocrinology Authors: Kiss, Z., Ghosh, P. M. Tags: Thematic Review Source Type: research
WOMEN IN CANCER THEMATIC REVIEW: Thyroid-stimulating hormone in thyroid cancer: does it matter?
Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surgery is often required for patients suspected to have malignancy. Serum thyroid-stimulating hormone (TSH) is higher in patients with malignant thyroid nodules than in those with benign disease, and TSH is proportionally increased in mo...
Source: Endocrine-Related Cancer - October 21, 2016 Category: Endocrinology Authors: Nieto, H., Boelaert, K. Tags: Thematic Review Source Type: research
WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer
Prostate cancer has, for decades, been treated by inhibiting androgen signalling. This is effective in the majority of patients, but inevitably resistance develops and patients progress to life-threatening metastatic disease – hence the quest for new effective therapies for ‘castrate-resistant’ prostate cancer (CRPC). Studies into what pathways can drive tumour recurrence under these conditions has identified several other nuclear receptor signalling pathways as potential drivers or modulators of CRPC.
The nuclear receptors constitute a large (48 members) superfamily of transcription factors sharing a com...
Source: Endocrine-Related Cancer - October 21, 2016 Category: Endocrinology Authors: Leach, D. A., Powell, S. M., Bevan, C. L. Tags: Thematic Review Source Type: research
WOMEN IN CANCER PROFILE: Dude, wheres my band?
(Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - October 21, 2016 Category: Endocrinology Authors: Ting, A. H. Tags: Profile Source Type: research
