Dissecting human antibody responses: useful, basic and surprising findings
Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target‐agnostic approach based on high‐throughput screening of antibodies produced by cultured B cells and plasma cells has not only provided potent and broadly neutralizing antibodies against a range of pathogens, but has also advanced our understanding of basic aspects of the immune response, from host–pathogen interaction to the r...
Source: EMBO Molecular Medicine - January 23, 2018 Category: Molecular Biology Authors: Antonio Lanzavecchia Tags: Louis ‐Jeantet Prize Winner: Commentary Source Type: research
The GPR120 agonist TUG ‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 17, 2018 Category: Molecular Biology Source Type: research
---
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 17, 2018 Category: Molecular Biology Source Type: research
CRTH2 promotes endoplasmic reticulum stress ‐induced cardiomyocyte apoptosis through m‐calpain
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Source Type: research
Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Source Type: research
Salivary glands regenerate after radiation injury through SOX2 ‐mediated secretory cell replacement
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Source Type: research
---
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Source Type: research
CRTH2 promotes endoplasmic reticulum stress ‐induced cardiomyocyte apoptosis through m‐calpain
Abstract
Apoptotic death of cardiac myocytes is associated with ischemic heart disease and chemotherapy‐induced cardiomyopathy. Chemoattractant receptor‐homologous molecule expressed on T helper type 2 cells (CRTH2) is highly expressed in the heart. However, its specific role in ischemic cardiomyopathy is not fully understood. Here, we demonstrated that CRTH2 disruption markedly improved cardiac recovery in mice postmyocardial infarction and doxorubicin challenge by suppressing cardiomyocyte apoptosis. Mechanistically, CRTH2 activation specifically facilitated endoplasmic reticulum (ER) stress‐induced cardiomyocyte a...
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Authors: Shengkai Zuo, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen, Ying Yu Tags: Research Article Source Type: research
Salivary glands regenerate after radiation injury through SOX2 ‐mediated secretory cell replacement
Abstract
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted therapeutics. However, the identity of these cells, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown. Using in vivo and ex vivo models, in combination with genetic lineage tracing and human tissue, we discover a SOX2+ stem cell population essential to acinar cell m...
Source: EMBO Molecular Medicine - January 15, 2018 Category: Molecular Biology Authors: Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz ‐Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox Tags: Research Article Source Type: research
Dual IRE1 RNase functions dictate glioblastoma development
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 8, 2018 Category: Molecular Biology Source Type: research
Loss of kallikrein ‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 8, 2018 Category: Molecular Biology Source Type: research
---
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - January 8, 2018 Category: Molecular Biology Source Type: research
