Sprouty2 loss ‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
Abstract
Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses significant therapeutic challenges. Deregulated receptor tyrosine kinase (RTK) signalling mediated by loss of tumour suppressor Sprouty2 (SPRY2) is associated with treatment resistance. Using pre‐clinical human and murine mCRPC models, we show that SPRY2 deficiency leads to an androgen self‐sufficient form of CRPC. Mechanistically, HER2‐IL6 signalling axis enhances the expression of androgen biosynthetic enzyme HSD3B1 and increases SRB1‐mediated cholesterol uptake in SPRY2‐deficie...
Source: EMBO Molecular Medicine - March 1, 2018 Category: Molecular Biology Authors: Rachana Patel, Janis Fleming, Ernest Mui, Carolyn Loveridge, Peter Repiscak, Arnaud Blomme, Victoria Harle, Mark Salji, Imran Ahmad, Katy Teo, Freddie C Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen J Sansom, Hing Y Leung Tags: Research Article Source Type: research
Retraction: “Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance”
Chris S Earl, Teh Wooi Keong, Shi‐qi An, Sarah Murdoch, Yvonne McCarthy, Junkal Garmendia, Joseph Ward, J Maxwell Dow, Liang Yang, George A O'Toole & Robert P Ryan
The above article, published May 20 2015 in EMBO Molecular Medicine, has been retracted by agreement between the authors of the study, CSE, TWK, SQA, SM, YMcC, JG, JW, JMD, LY, RPR, the journal Chief Editor and the EMBO Head of Scientific Publications in accordance with the outcomes of independent investigations conducted by the University of Dundee and University College Cork.
GAO'T disagrees with the text of this retraction notice, albeit not with the re...
Source: EMBO Molecular Medicine - March 1, 2018 Category: Molecular Biology Tags: Retraction Source Type: research
Tranilast directly targets NLRP3 to treat inflammasome ‐driven diseases
Abstract
The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases, but the medications targeting NLRP3 inflammasome are not available in clinic. Here, we show that tranilast (TR), an old anti‐allergic clinical drug, is a direct NLRP3 inhibitor. TR inhibits NLRP3 inflammasome activation in macrophages, but has no effects on AIM2 or NLRC4 inflammasome activation. Mechanismly, TR directly binds to the NACHT domain of NLRP3 and suppresses the assembly of NLRP3 inflammasome by blocking NLRP3 oligomerization. In vivo experiments show that TR has r...
Source: EMBO Molecular Medicine - March 1, 2018 Category: Molecular Biology Authors: Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou Tags: Research Article Source Type: research
Dual inhibition of AKT ‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer
Abstract
AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate cancer cells and its overexpression correlates with AKT phosphorylation in patient samples. HDAC3 facilitates lysine‐63‐chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1. Conditional...
Source: EMBO Molecular Medicine - March 1, 2018 Category: Molecular Biology Authors: Yuqian Yan, Jian An, Yinhui Yang, Di Wu, Yang Bai, William Cao, Linlin Ma, Junhui Chen, Zhendong Yu, Yundong He, Xin Jin, Yunqian Pan, Tao Ma, Shangqian Wang, Xiaonan Hou, Saravut John Weroha, R Jeffrey Karnes, Jun Zhang, Jennifer J Westendorf, Liguo Wang Tags: Research Article Source Type: research
An allosteric inhibitor of Mycobacterium tuberculosis ArgJ: Implications to a novel combinatorial therapy
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 26, 2018 Category: Molecular Biology Source Type: research
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EMBO Molecular Medicine, Ahead of Print. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 26, 2018 Category: Molecular Biology Source Type: research
Counteracting the effects of TNF receptor ‐1 has therapeutic potential in Alzheimer's disease
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 22, 2018 Category: Molecular Biology Source Type: research
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EMBO Molecular Medicine, Ahead of Print. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 22, 2018 Category: Molecular Biology Source Type: research
An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 20, 2018 Category: Molecular Biology Source Type: research
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EMBO Molecular Medicine, Ahead of Print. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 20, 2018 Category: Molecular Biology Source Type: research
Role of NKp46+ natural killer cells in house dust mite ‐driven asthma
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 15, 2018 Category: Molecular Biology Source Type: research
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non ‐small cell lung cancer
EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 15, 2018 Category: Molecular Biology Source Type: research
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EMBO Molecular Medicine, Ahead of Print. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 15, 2018 Category: Molecular Biology Source Type: research
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EMBO Molecular Medicine,Volume 10, Issue 3, March 2018. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - February 15, 2018 Category: Molecular Biology Source Type: research
Role of NKp46+ natural killer cells in house dust mite ‐driven asthma
Abstract
House dust mite (HDM)‐allergic asthma is driven by T helper 2 (Th2) lymphocytes, but also innate immune cells control key aspects of the disease. The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has been very confusing, in part because different, not entirely specific, strategies were used to target these cells. We show that HDM inhalation rapidly led to the accumulation of NK cells in the lung‐draining lymph nodes and of activated CD69+ NK cells in the bronchoalveolar lumen. However, genetically engineered Ncr1‐DTA or Ncr1‐DTR mice that constitutivel...
Source: EMBO Molecular Medicine - February 15, 2018 Category: Molecular Biology Authors: Eline Haspeslagh, Mary J Helden, Kim Deswarte, Sofie De Prijck, Justine Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht Tags: Research Article Source Type: research
