High ‐affinity interactions and signal transduction between Aβ oligomers and TREM2
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - October 19, 2018 Category: Molecular Biology Authors: Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde Source Type: research

A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - October 15, 2018 Category: Molecular Biology Authors: Justyna A Dobrowolska Zakaria, Robert J Vassar Source Type: research

Cancer immunotherapy in routine cost ‐effective cancer care?
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - October 15, 2018 Category: Molecular Biology Authors: Sir Marc Feldmann Source Type: research

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - October 11, 2018 Category: Molecular Biology Authors: Gabriele Civiletto, Sukru Anil Dogan, Raffaele Cerutti, Gigliola Fagiolari, Maurizio Moggio, Costanza Lamperti, Cristiane Beninc á, Carlo Viscomi, Massimo Zeviani Source Type: research

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - October 2, 2018 Category: Molecular Biology Authors: Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider ‐Anthony, Karine Merienne, Brigitte Cosquer, Laura Tzeplaeff, Sarmistha Halder Sinha, Manoj Kumar, Piyush Chaturbedy, Muthusamy Eswaramoorthy, Stéphanie Le Gras, Céline Keime, Olivier Source Type: research

Early auto ‐immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 28, 2018 Category: Molecular Biology Authors: Mayur Dembla, Ajay Kesharwani, Sivaraman Natarajan, Claudia Fecher ‐Trost, Richard Fairless, Sarah K Williams, Veit Flockerzi, Ricarda Diem, Karin Schwarz, Frank Schmitz Source Type: research

USP14 inhibition corrects an in  vivo model of impaired mitophagy
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 24, 2018 Category: Molecular Biology Authors: Joy Chakraborty, Sophia Stockum, Elena Marchesan, Federico Caicci, Vanni Ferrari, Aleksandar Rakovic, Christine Klein, Angelo Antonini, Luigi Bubacco, Elena Ziviani Source Type: research

Modulation of three key innate immune pathways for the most common retinal degenerative diseases
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 17, 2018 Category: Molecular Biology Authors: Isha Akhtar ‐Schäfer , Luping Wang , Tim U Krohne , Heping Xu , Thomas Langmann Source Type: research

MicroRNA therapy for infected wounds
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 17, 2018 Category: Molecular Biology Authors: Paul Hiebert , Sabine Werner Source Type: research

The BACE ‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 17, 2018 Category: Molecular Biology Authors: Ulf Neumann , Mike Ufer , Laura H Jacobson , Marie ‐Laure Rouzade‐Dominguez , Gunilla Huledal , Carine Kolly , Rainer M Lüönd , Rainer Machauer , Siem J Veenstra , Konstanze Hurth , Heinrich Rueeger , Marina Tintelnot‐Blomle Source Type: research

In vivo generation of human CD19 ‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 17, 2018 Category: Molecular Biology Authors: Anett Pfeiffer , Frederic B Thalheimer , Sylvia Hartmann , Annika M Frank , Ruben R Bender , Simon Danisch , Caroline Costa , Winfried S Wels , Ute Modlich , Renata Stripecke , Els Verhoeyen , Christian J Buchholz Source Type: research

OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 10, 2018 Category: Molecular Biology Authors: Kyle Thompson , Nicole Mai , Monika Ol áhová , Filippo Scialó , Luke E Formosa , David A Stroud , Madeleine Garrett , Nichola Z Lax , Fiona M Robertson , Cristina Jou , Andres Nascimento , Carlos Ortez , Cecilia Jimenez‐Malleb Source Type: research

Mutations in TIMM50 compromise cell survival in OxPhos ‐dependent metabolic conditions
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 6, 2018 Category: Molecular Biology Authors: Aurelio Reyes , Laura Melchionda , Alberto Burlina , Alan J Robinson , Daniele Ghezzi , Massimo Zeviani Source Type: research

Selective depletion of metastatic stem cells as therapy for human colorectal cancer
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 6, 2018 Category: Molecular Biology Authors: Mar ía Virtudes Céspedes , Ugutz Unzueta , Anna Aviñó , Alberto Gallardo , Patricia Álamo , Rita Sala , Alejandro Sánchez‐Chardi , Isolda Casanova , María Antònia Mangues , Antonio Lopez‐Pousa , Ramón Eritja , Antonio Source Type: research

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - September 6, 2018 Category: Molecular Biology Authors: Jacob Insua ‐Rodríguez , Maren Pein , Tsunaki Hongu , Jasmin Meier , Arnaud Descot , Camille M Lowy , Etienne De Braekeleer , Hans‐Peter Sinn , Saskia Spaich , Marc Sütterlin , Andreas Schneeweiss , Thordur Oskarsson Source Type: research