A versatile drug delivery system targeting senescent cells
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 16, 2018 Category: Molecular Biology Authors: Daniel Mu ñoz‐Espín , Miguel Rovira , Irene Galiana , Cristina Giménez , Beatriz Lozano‐Torres , Marta Paez‐Ribes , Susana Llanos , Selim Chaib , Maribel Muñoz‐Martín , Alvaro C Ucero , Guillermo Garaulet , Francisca M Source Type: research

mitoTev ‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 16, 2018 Category: Molecular Biology Authors: Claudia V Pereira , Sandra R Bacman , Tania Arguello , Ugne Zekonyte , Sion L Williams , David R Edgell , Carlos T Moraes Source Type: research

LETM1 couples mitochondrial DNA metabolism and nutrient preference
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 16, 2018 Category: Molecular Biology Authors: Romina Durigon , Alice L Mitchell , Aleck WE Jones , Andreea Manole , Mara Mennuni , Elizabeth MA Hirst , Henry Houlden , Giuseppe Maragni , Serena Lattante , Paolo Niccolo ’ Doronzio , Ilaria Dalla Rosa , Marcella Zollino , Ian Source Type: research

Aberrant regulation of the GSK ‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 11, 2018 Category: Molecular Biology Authors: Pablo Ranea ‐Robles , Nathalie Launay , Montserrat Ruiz , Noel Ylagan Calingasan , Magali Dumont , Alba Naudí , Manuel Portero‐Otín , Reinald Pamplona , Isidre Ferrer , M Flint Beal , Stéphane Fourcade , Aurora Pujol Source Type: research

FGF21 gene therapy as treatment for obesity and insulin resistance
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 9, 2018 Category: Molecular Biology Authors: Veronica Jimenez , Claudia Jambrina , Estefania Casana , Victor Sacristan , Sergio Mu ñoz , Sara Darriba , Jordi Rodó , Cristina Mallol , Miquel Garcia , Xavier León , Sara Marcó , Albert Ribera , Ivet Elias , Alba Casellas , Source Type: research

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 5, 2018 Category: Molecular Biology Authors: Lise Van Wyngene , Jolien Vandewalle , Claude Libert Source Type: research

Cited4 is a sex ‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 4, 2018 Category: Molecular Biology Authors: Irem Bayindir ‐Buchhalter , Gretchen Wolff , Sarah Lerch , Tjeerd Sijmonsma , Maximilian Schuster , Jan Gronych , Adrian T Billeter , Rohollah Babaei , Damir Krunic , Lars Ketscher , Nadine Spielmann , Martin Hrabe de Angelis , Source Type: research

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - July 4, 2018 Category: Molecular Biology Authors: Alazne Zabala , Nuria Vazquez ‐Villoldo , Björn Rissiek , Jon Gejo , Abraham Martin , Aitor Palomino , Alberto Perez‐Samartín , Krishna R Pulagam , Marco Lukowiak , Estibaliz Capetillo‐Zarate , Jordi Llop , Tim Magnus , Fri Source Type: research

Deficiency in intestinal epithelial O ‐GlcNAcylation predisposes to gut inflammation
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 25, 2018 Category: Molecular Biology Authors: Ming Zhao , Xiwen Xiong , Kaiqun Ren , Bing Xu , Meng Cheng , Chinmayi Sahu , Kaichun Wu , Yongzan Nie , Zan Huang , Richard S Blumberg , Xiaonan Han , Hai ‐Bin Ruan Source Type: research

Soluble stroma ‐related biomarkers of pancreatic cancer
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 25, 2018 Category: Molecular Biology Authors: Andrea Resovi , Maria Rosa Bani , Luca Porcu , Alessia Anastasia , Lucia Minoli , Paola Allavena , Paola Cappello , Francesco Novelli , Aldo Scarpa , Eugenio Morandi , Anna Falanga , Valter Torri , Giulia Taraboletti , Dorina B Source Type: research

A HIF –LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 22, 2018 Category: Molecular Biology Authors: Daniel E Foxler , Katherine S Bridge , John G Foster , Paul Grevitt , Sean Curry , Kunal M Shah , Kathryn M Davidson , Ai Nagano , Emanuela Gadaleta , Hefin I Rhys , Paul T Kennedy , Miguel A Hermida , Ting ‐Yu Chang , Source Type: research

Hepato ‐entrained B220+CD11c+NK1.1+ cells regulate pre‐metastatic niche formation in the lung
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 22, 2018 Category: Molecular Biology Authors: Sachie Hiratsuka , Takeshi Tomita , Taishi Mishima , Yuta Matsunaga , Tsutomu Omori , Sachie Ishibashi , Satoshi Yamaguchi , Tsuyoshi Hosogane , Hiroshi Watarai , Miyuki Omori ‐Miyake , Tomoko Yamamoto , Noriyuki Shibata , Akira Source Type: research

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2 ‐dependent transcription in cardiac myocytes
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 15, 2018 Category: Molecular Biology Authors: Andr ás D Tóth , Richard Schell , Magdolna Lévay , Christiane Vettel , Philipp Theis , Clemens Haslinger , Felix Alban , Stefanie Werhahn , Lina Frischbier , Jutta Krebs‐Haupenthal , Dominique Thomas , Hermann‐Josef Gröne , Source Type: research

Myeloid p38 α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 15, 2018 Category: Molecular Biology Authors: Catrin Youssif , Monica Cubillos ‐Rojas , Mònica Comalada , Elisabeth Llonch , Cristian Perna , Nabil Djouder , Angel R Nebreda Source Type: research

Brain ‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms
EMBO Molecular Medicine, EarlyView. (Source: EMBO Molecular Medicine)
Source: EMBO Molecular Medicine - June 8, 2018 Category: Molecular Biology Authors: H élène FE Gleitz , Ai Yin Liao , James R Cook , Samuel F Rowlston , Gabriella MA Forte , Zelpha D'Souza , Claire O'Leary , Rebecca J Holley , Brian W Bigger Source Type: research