Dopamine and serotonin regulate tumor behavior by affecting angiogenesis
The biogenic amines dopamine and serotonin are neurotransmitters and hormones, which are mainly produced in the central nervous system and in the gastro-intestinal tract. They execute local and systemic functions such as intestinal motility and tissue repair. Dopamine and serotonin are primarily stored in and transported by platelets. This review focuses on the recently recognized role of dopamine and serotonin in the regulation of tumor behavior by affecting angiogenesis and tumor cell proliferation. (Source: Drug Resistance Updates)
Source: Drug Resistance Updates - September 19, 2014 Category: Drugs & Pharmacology Authors: Marloes A.M. Peters, Annemiek M.E. Walenkamp, Ido P. Kema, Coby Meijer, Elisabeth G.E. de Vries, Sjoukje F. Oosting Source Type: research
What should be considered in the treatment of bacterial infections by multi-drug therapies: A mathematical perspective?
Bacterial infections are a global health concern with high levels of mortality and morbidity associated. The resistance of pathogens to drugs is one leading cause of this problem, being common the administration of multiple drugs to improve the therapeutic effects.This review critically explores diverse aspects involved in the treatment of bacterial infections through multi-drug therapies, from a mathematical and within-host perspectives. Five recent models were selected and are reviewed. These models fall into the following question: which drugs to select, the respective dose, the administration period to effectively erad...
Source: Drug Resistance Updates - August 12, 2014 Category: Drugs & Pharmacology Authors: Francisco Pimenta, Ana Cristina Abreu, Lúcia Chaves Simões, Manuel Simões Source Type: research
Prediction of dynamical drug sensitivity and resistance by module network rewiring-analysis based on transcriptional profiling
Revealing functional reorganization or module rewiring between modules at network levels during drug treatment is important to systematically understand therapies and drug responses. The present article proposed a novel model of module network rewiring to characterize functional reorganization of a complex biological system, and described a new framework named as module network rewiring-analysis (MNR) for systematically studying dynamical drug sensitivity and resistance during drug treatment. MNR was used to investigate functional reorganization or rewiring on the module network, rather than molecular network or individual...
Source: Drug Resistance Updates - August 12, 2014 Category: Drugs & Pharmacology Authors: Tao Zeng, Diane Catherine Wang, Xiangdong Wang, Feng Xu, Luonan Chen Source Type: research
The role of azoles in the management of azole-resistant aspergillosis: From the bench to the bedside
Azole resistance is an emerging problem in Aspergillus fumigatus and is associated with a high probability of treatment failure. An azole resistance mechanism typically decreases the activity of multiple azole compounds, depending on the mutation. As alternative treatment options are limited and in some isolates the minimum inhibitory concentration (MIC) increases by only a few two-fold dilutions steps, we investigated if voriconazole and posaconazole have a role in treating azole-resistant Aspergillus disease. (Source: Drug Resistance Updates)
Source: Drug Resistance Updates - July 4, 2014 Category: Drugs & Pharmacology Authors: Seyedmojtaba Seyedmousavi, Johan W. Mouton, Willem J.G. Melchers, Roger J.M. Brüggemann, Paul E. Verweij Source Type: research
The role of azoles in the management of azole-resistant aspergillosis: From the bench to the bedside
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - July 4, 2014 Category: Drugs & Pharmacology Authors: Seyedmojtaba Seyedmousavi, Johan W. Mouton, Willem J.G. Melchers, Roger J.M. Brüggemann, Paul E. Verweij Source Type: research
Editorial Board
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - July 1, 2014 Category: Drugs & Pharmacology Source Type: research
Linezolid update: Stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms
Abstract: Linezolid, approved for clinical use since 2000, has become an important addition to the anti-Gram-positive infection armamentarium. This oxazolidinone drug has in vitro and in vivo activity against essentially all Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The in vitro activity of linezolid was well documented prior to its clinical application, and several ongoing surveillance studies demonstrated consistent and potent results during the subsequent years of clinical use. Emergence of resistance has been limited and associated ...
Source: Drug Resistance Updates - May 30, 2014 Category: Drugs & Pharmacology Authors: Rodrigo E. Mendes, Lalitagauri M. Deshpande, Ronald N. Jones Tags: Articles Source Type: research
Nanoways to overcome docetaxel resistance in prostate cancer
Abstract: Prostate cancer is the most common non-cutaneous malignancy in American men. Docetaxel is a useful chemotherapeutic agent for prostate cancer that has been available for over a decade, but the length of the treatment and systemic side effects hamper compliance. Additionally, docetaxel resistance invariably emerges, leading to disease relapse. Docetaxel resistance is either intrinsic or acquired by adopting various mechanisms that are highly associated with genetic alterations, decreased influx and increased efflux of drugs. Several combination therapies and small P-glycoprotein inhibitors have been proposed to im...
Source: Drug Resistance Updates - May 21, 2014 Category: Drugs & Pharmacology Authors: Aditya Ganju, Murali M. Yallapu, Sheema Khan, Stephen W. Behrman, Subhash C. Chauhan, Meena Jaggi Tags: Articles Source Type: research
Linezolid update: Stable activity following more than a decade of clinical use and summary of associated resistance mechanisms
Linezolid, approved for clinical use since 2000, has become an important addition to the anti-Gram-positive infection armamentarium. This oxazolidinone drug has in vitro and in vivo activity against essentially all Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The in vitro activity of linezolid was well documented prior to its clinical application, and several ongoing surveillance studies demonstrated consistent and potent results during the subsequent years of clinical use. (Source: Drug Resistance Updates)
Source: Drug Resistance Updates - April 6, 2014 Category: Drugs & Pharmacology Authors: Rodrigo E. Mendes, Lalitagauri M. Deshpande, Ronald N. Jones Tags: Articles Source Type: research
Linezolid update: Stable activity following more than a decade of clinical use and summary of associated resistance mechanisms
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - April 6, 2014 Category: Drugs & Pharmacology Authors: Rodrigo E. Mendes, Lalitagauri M. Deshpande, Ronald N. Jones Tags: Articles Source Type: research
Nanoways to overcome docetaxel resistance in prostate cancer
Prostate cancer is the most common non-cutaneous malignancy in American men. Docetaxel is a useful chemotherapeutic agent for prostate cancer that has been available for over a decade, but the length of the treatment and systemic side effects hamper compliance. Additionally, docetaxel resistance invariably emerges, leading to disease relapse. Docetaxel resistance is either intrinsic or acquired by adopting various mechanisms that are highly associated with genetic alterations, decreased influx and increased efflux of drugs. (Source: Drug Resistance Updates)
Source: Drug Resistance Updates - April 5, 2014 Category: Drugs & Pharmacology Authors: Aditya Ganju, Murali M. Yallapu, Sheema Khan, Stephen W. Behrman, Subhash C. Chauhan, Meena Jaggi Tags: Articles Source Type: research
Nanoways to overcome docetaxel resistance in prostate cancer
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - April 5, 2014 Category: Drugs & Pharmacology Authors: Aditya Ganju, Murali M. Yallapu, Sheema Khan, Stephen W. Behrman, Subhash C. Chauhan, Meena Jaggi Tags: Articles Source Type: research
