Dopamine and serotonin regulate tumor behavior by affecting angiogenesis

The biogenic amines dopamine and serotonin are neurotransmitters and hormones, which are mainly produced in the central nervous system and in the gastro-intestinal tract. They execute local and systemic functions such as intestinal motility and tissue repair. Dopamine and serotonin are primarily stored in and transported by platelets. This review focuses on the recently recognized role of dopamine and serotonin in the regulation of tumor behavior by affecting angiogenesis and tumor cell proliferation.

Source: Drug Resistance Updates - September 19, 2014 Category: Drugs & Pharmacology Authors: Marloes A.M. Peters, Annemiek M.E. Walenkamp, Ido P. Kema, Coby Meijer, Elisabeth G.E. de Vries, Sjoukje F. Oosting Source Type: research