Prediction of dynamical drug sensitivity and resistance by module network rewiring-analysis based on transcriptional profiling

Revealing functional reorganization or module rewiring between modules at network levels during drug treatment is important to systematically understand therapies and drug responses. The present article proposed a novel model of module network rewiring to characterize functional reorganization of a complex biological system, and described a new framework named as module network rewiring-analysis (MNR) for systematically studying dynamical drug sensitivity and resistance during drug treatment. MNR was used to investigate functional reorganization or rewiring on the module network, rather than molecular network or individual molecules.

Source: Drug Resistance Updates - August 12, 2014 Category: Drugs & Pharmacology Authors: Tao Zeng, Diane Catherine Wang, Xiangdong Wang, Feng Xu, Luonan Chen Source Type: research