The role of azoles in the management of azole-resistant aspergillosis: From the bench to the bedside

Azole resistance is an emerging problem in Aspergillus fumigatus and is associated with a high probability of treatment failure. An azole resistance mechanism typically decreases the activity of multiple azole compounds, depending on the mutation. As alternative treatment options are limited and in some isolates the minimum inhibitory concentration (MIC) increases by only a few two-fold dilutions steps, we investigated if voriconazole and posaconazole have a role in treating azole-resistant Aspergillus disease.
Source: Drug Resistance Updates - Category: Drugs & Pharmacology Authors: Source Type: research