Editorial Board
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - July 1, 2013 Category: Drugs & Pharmacology Source Type: research
MicroRNAs as therapeutic targets in chemoresistance
Abstract: Despite substantial progress in understanding the cancer signaling network, effective therapies remain scarce due to insufficient disruption of oncogenic pathways, drug resistance and drug-induced toxicity. New and more creative approaches are therefore required for the treatment of cancer. MicroRNAs (miRNAs) are a family of small noncoding RNAs that regulate gene expression by sequence-selective targeting of mRNAs, leading to a translational repression or mRNA degradation. Experimental evidence demonstrates that dysregulation of specific miRNAs leads to drug resistance in different cancers and correction of thes...
Source: Drug Resistance Updates - June 11, 2013 Category: Drugs & Pharmacology Authors: Michela Garofalo, Carlo M. Croce Tags: Articles Source Type: research
The role of asymptomatic P. falciparum parasitaemia in the evolution of antimalarial drug resistance in areas of seasonal transmission
Abstract: In areas with seasonal transmission, proper management of acute malaria cases that arise in the transmission season can markedly reduce the disease burden. However, asymptomatic carriage of Plasmodium falciparum sustains a long-lasting reservoir in the transmission-free dry season that seeds cyclical malaria outbreaks. Clinical trials targeting asymptomatic parasitaemia in the dry season failed to interrupt the malaria epidemics that follow annual rains. These asymptomatic infections tend to carry multiple-clones, capable of producing gametocytes and infecting Anopheles mosquitoes. Different clones within an infe...
Source: Drug Resistance Updates - March 18, 2013 Category: Drugs & Pharmacology Authors: Hamza A. Babiker, Amal A.H. Gadalla, Lisa C. Ranford-Cartwright Source Type: research
Understanding the functions of tumor stroma in resistance to ionizing radiation: Emerging targets for pharmacological modulation
Abstract: Maintenance of both normal epithelial tissues and their malignant counterparts is supported by the host tissue stroma. The tumor stroma mainly consists of the basement membrane, fibroblasts, extracellular matrix, immune cells, and vasculature. Although most host cells in the stroma possess certain tumor-suppressing abilities, the stroma will change during malignancy and eventually promote growth, invasion, and metastasis. There is growing evidence that the stroma influences importantly the response to radiation therapy (RT). On the one hand, irradiation releases numerous inflammatory cytokines within the extracel...
Source: Drug Resistance Updates - February 22, 2013 Category: Drugs & Pharmacology Authors: Cyrus Chargari, Céline Clemenson, Isabelle Martins, Jean-Luc Perfettini, Eric Deutsch Source Type: research
Extended-spectrum cephalosporin-resistant gram-negative organisms in livestock: An emerging problem for human health?
Abstract: Escherichia coli, Salmonella spp. and Acinetobacter spp. are important human pathogens. Serious infections due to these organisms are usually treated with extended-spectrum cephalosporins (ESCs). However, in the past two decades we have faced a rapid increasing of infections and colonization caused by ESC-resistant (ESC-R) isolates due to production of extended-spectrum-β-lactamases (ESBLs), plasmid-mediated AmpCs (pAmpCs) and/or carbapenemase enzymes. This situation limits drastically our therapeutic armamentarium and puts under peril the human health. Animals are considered as potential reservoirs of multidrug...
Source: Drug Resistance Updates - February 7, 2013 Category: Drugs & Pharmacology Authors: Salome N. Seiffert, Markus Hilty, Vincent Perreten, Andrea Endimiani Source Type: research
Editorial Board
(Source: Drug Resistance Updates)
Source: Drug Resistance Updates - February 1, 2013 Category: Drugs & Pharmacology Source Type: research
