Availability, Use, and Barriers to Cardiac Rehabilitation in LMIC
Cardiac rehabilitation (CR) is a cornerstone of secondary prevention of ischemic heart disease. It is critically important in low- and middle-income countries (LMIC), where the burden of ischemic heart disease is substantial and growing. However, the availability and utilization of CR in LMIC is not systematically known. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: Loheetha Ragupathi, Judy Stribling, Yuliya Yakunina, Valentin Fuster, Mary Ann McLaughlin, Rajesh Vedanthan Tags: Original Research Source Type: research
Feasibility of Using Mobile ECG Recording Technology to Detect Atrial Fibrillation in Low-Resource Settings
Screening for atrial fibrillation (AF), a major risk factor for stroke that is on the rise in Africa, is becoming increasingly critical. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: Grahame F. Evans, Arianna Shirk, Peter Muturi, Elsayed Z. Soliman Tags: Original Research Source Type: research
The 22q11.2 Deletion Syndrome in Congenital Heart Defects
The 22q11.2 deletion syndrome is amongst the most common microdeletion syndrome in humans. Its prevalence remains unknown in sub-Saharan Africa, and its clinical features are under-reported for people of African descent. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: Ambroise Wonkam, Ricardo Toko, David Chelo, Cedrik Tekendo-Ngongang, Samuel Kingue, Sophie Dahoun Tags: Original Research Source Type: research
Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. As such, various classes of drugs have been developed to inhibit this system. These drugs are aimed at preventing angiotensin II from performing its function by inhibiting angiotensin II receptors or inhibiting angiotensin-converting enzyme from converting angiotensin I to angiotensin II. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: David K. Brown, Olivier Sheik Amamuddy, Özlem Tastan Bishop Tags: Review Source Type: research
Genomics Research for a New Age
Cardiometabolic diseases are major contributors to mortality and morbidity, and their burden displays global and regional disparities. Gene-environment interactions contribute to the pathogenesis of cardiometabolic diseases. Population differences in genetic structure, ancient environmental pressures that shape the human genome, and early life environmental adversities (e.g., in utero conditions) all contribute to observed disparities in global cardiometabolic diseases. The genetic and sociocultural diversity of global populations presents opportunities for discovering genomic loci that influence cardiometabolic diseases a...
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: Fasil Tekola-Ayele, Emmanuel Peprah Tags: Review Source Type: research
Role of Structural Bioinformatics in Drug Discovery by Computational SNP Analysis
With the completion of the human genome project at the beginning of the 21st century, the biological sciences entered an unprecedented age of data generation, and made its first steps toward an era of personalized medicine. This abundance of sequence data has led to the proliferation of numerous sequence-based techniques for associating variation with disease, such as genome-wide association studies and candidate gene association studies. However, these statistical methods do not provide an understanding of the functional effects of variation. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: David K. Brown, Özlem Tastan Bishop Tags: Review Source Type: research
Can We Better Understand the Evolutionary Biology of CVD From Analysis of Ancestral Population Genomes?
Understanding the evolutionary history of human adaptation is essential to understanding human biology today. Humans went through several stages of evolution in the past 40,000 years showing remarkable variations both within and between populations in a number of phenotypic traits, such as pigmentation, height, food preference/diet, heat tolerance and cold stress responses, and susceptibility to communicable and noncommunicable diseases. This diversity that exists in modern-day humans is a culmination of genetic, environmental, and cultural adaptations that have occurred under various selective pressures acting over differ...
Source: CVD Prevention and Control - March 12, 2017 Category: Global & Universal Authors: Muntaser Ibrahim, Maha Osman, Emmanuel Peprah Tags: Editorial Viewpoint Source Type: research
RF and RHD Research
“The future is already here — it's just not very evenly distributed.”—William Gibson (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 1, 2017 Category: International Medicine & Public Health Authors: George A. Mensah, Michael M. Engelgau Tags: Perspectives From NHLBI Source Type: research
Moving Forward the RHD Agenda at Global and National Levels
Rheumatic heart disease (RHD) remains a persistent threat to the health of children and working-age adults in many low- and middle-income countries (LMIC). Although at the global level significant progress has been made on RHD mortality since 1990, a number of countries in sub-Saharan Africa, South Asia, and Oceania have been left behind with persistently high mortality rates [1]. More than 30 million people around the world are currently living with RHD [2], and nearly all of them are in countries with weak health systems that offer poor coverage of secondary prevention measures and low access to advanced medical and surg...
Source: CVD Prevention and Control - March 1, 2017 Category: International Medicine & Public Health Authors: David A. Watkins, Liesel J. Z ühlke, Jagat Narula Tags: Editor ’s Page Source Type: research
Table of Contents
(Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 1, 2017 Category: International Medicine & Public Health Source Type: research
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD?
It is estimated that 32.9 million individuals experience rheumatic heart disease (RHD) globally, with about 275,000 deaths occurring each year. The majority of cases occur in South Asia and sub-Saharan Africa. The disability adjusted life years (DALYs) lost from RHD is estimated to be about 9.5 million, with the majority being in low- and middle-income countries (this burden is similar to that of acute leukemia). Between 2000 and 2012, the number of deaths from RHD declined by 9% (from 372,000 to 337,000) and DALYs declined 6% (from 14.3 million to 11.9 million) globally [1]. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - March 1, 2017 Category: International Medicine & Public Health Authors: Salim Yusuf, Jagat Narula, Habib Gamra Tags: Editorial Comment Source Type: research
A Comprehensive Needs Assessment Tool for Planning RHD Control Programs in Limited Resource Settings
We present a RHD Needs Assessment Tool (NAT) that can be used at country or regional levels to systematically develop and plan comprehensive RHD control programs and to provide baseline data for program monitoring and evaluation. The RHD NAT follows a mixed-methods approach using quantitative and qualitative data collection instruments. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - February 28, 2017 Category: International Medicine & Public Health Authors: Liesl J. Z ühlke, David A. Watkins, Susan Perkins, Rosemary Wyber, Jeremiah Mwangi, Joanna Markbreiter, Hlengiwe S. Moloi, Mark E. Engel, Thembikile Shato, Tayla Hermanus, Jantina DeVries, Clancy Read Tags: Innovations and Concepts Source Type: research
A Comprehensive Needs Assessment Tool for Planning Rheumatic Heart Disease Control Programs in Limited Resource Settings
We present a RHD Needs Assessment Tool (NAT) that can be used at country or regional levels to systematically develop and plan comprehensive RHD control programs and to provide baseline data for program monitoring and evaluation. The RHD NAT follows a mixed-methods approach using quantitative and qualitative data collection instruments. (Source: CVD Prevention and Control)
Source: CVD Prevention and Control - February 27, 2017 Category: Global & Universal Authors: Liesl J. Z ühlke, David A. Watkins, Susan Perkins, Rosemary Wyber, Jeremiah Mwangi, Joanna Markbreiter, Hlengiwe S. Moloi, Mark E. Engel, Thembikile Shato, Tayla Hermanus, Jantina DeVries, Clancy Read Tags: Innovations and Concepts Source Type: research
The Effectiveness of Community Health Workers in CVD Prevention in LMIC
Community health workers (CHW) may be effective in tackling the burden of cardiovascular diseases in low- and middle-income countries (LMIC). This review examines whether CHWs can improve the identification and control of cardiovascular risk factors in LMIC. We searched for studies that used CHW as a basis for cardiovascular risk factor management. Our search yielded 11 articles that targeted cardiovascular risk factor assessment, hypertension, diabetes, smoking, diet and physical activity. There were 4 randomized controlled trials, 3 quasi-experimental studies, 3 cross-sectional studies, and 1 retrospective analysis. (Sou...
Source: CVD Prevention and Control - December 15, 2016 Category: Cardiology Authors: Aditya K. Khetan, Raghunandan Purushothaman, Tarek Chami, Vittal Hejjaji, Sri Krishna Madan Mohan, Richard A. Josephson, Allison R. Webel Tags: Review Source Type: research
The Need for Brazil to Focus on CVD
Over the last 5 decades, cardiovascular disease (CVD) has been the leading cause of death in Brazil. This epidemiological scenario is closely related to lifestyle changes due to urbanization, globalization, and population aging along with the increase in life expectancy in the Brazilian population [1]. In 2011, a total of 384,615 deaths were attributed to CVD in Brazil, after correction for under-reporting and poorly defined causes, which correspond to 31% of all deaths. Among CVD deaths, 31% were related to coronary heart disease, 30% to cerebrovascular disease, 14% to hypertension, and 18% to other causes [2]. (Source: C...
Source: CVD Prevention and Control - November 30, 2016 Category: Cardiology Authors: Diandro Mota, Ant ônio Cordeiro Mattos, Gustavo Oliveira, Alvaro Avezum Tags: Viewpoint Source Type: research
