Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. As such, various classes of drugs have been developed to inhibit this system. These drugs are aimed at preventing angiotensin II from performing its function by inhibiting angiotensin II receptors or inhibiting angiotensin-converting enzyme from converting angiotensin I to angiotensin II.
Source: CVD Prevention and Control - Category: Global & Universal Authors: David K. Brown, Olivier Sheik Amamuddy, Özlem Tastan Bishop Tags: Review Source Type: research