Parallel definition of tear film maps on distributed-memory clusters for the support of dry eye diagnosis
• Tear film maps can be used in the diagnosis of the dry eye syndrome• Method to accelerate the generation of tear film maps on distributed-memory clusters• Novel hybrid parallel approach using MPI and multithreading• Time reduced from around 2 minutes in the state of the art to less than 10 seconds• Runtime reduction can extend the use of tear film maps among medical experts (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 30, 2016 Category: Bioinformatics Authors: Jorge Gonz ález-Domínguez, Beatriz Remeseiro, María J. Martín Source Type: research

Hydra: A web-based system for cardiovascular analysis, diagnosis and treatment
• Hydra is a platform that helps the cardiovascular diagnosis and treatment.• The contribution implies more accurate clinical results and reducing costs.• Hydra provides integral data management and ambulatory blood pressure monitoring.• The information is presented in medical reports that e ase their understanding.• The platform has proven its great potential in cardiovascular clinical studies. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 27, 2016 Category: Bioinformatics Authors: J. Novo, A. Hermida, M. Ortega, N. Barreira, M.G. Penedo, J.E. L ópez, C. Calvo Source Type: research

Computer-aided grading of gliomas based on local and global MRI features
• Numerous quantitative image features were developed from brain MR images to characterize gliomas of different gradings.• Image features including local texture and global histogram moment features were combined for malignancy evaluation.• The likelihoods of malignancy of tumors were predicte d by a logistic regression model using image features in a computer-aided diagnosis system which can provides diagnostic decisions to radiologists. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 26, 2016 Category: Bioinformatics Authors: Chung-Ming Lo, Li-Chun Hsieh, Chih-Jou Hsiao Source Type: research

A clinical decision-making mechanism for context-aware and patient-specific remote monitoring systems using the correlations of multiple vital signs
• We developed a clinical decision support system for vital sign predictions.• We used patient-specific vital sing correlations for detecting future value.• We utilized multi-label classification algorithms for classifier design.• Our developed tool can help doctors in diagnostic decision ma king.• Our developed model can support many patients simultaneously. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 26, 2016 Category: Bioinformatics Authors: Abdur Rahim Mohammad Forkan, Ibrahim Khalil Source Type: research

Improving recovery of ECG signal with deterministic guarantees using split signal for multiple supports of matching pursuit (SS-MSMP) algorithm
The compressed sensing (CS) is a new field used for signal acquisition and design of sensor that made a large drooping in the cost of acquiring sparse signals. In this paper, new algorithms are developed to improve the performance of the greedy algorithms.In this paper new greedy pursuit algorithms; SS-MSMP (Split Signal for Multiple Support of Matching Pursuit) is introduced and theoretical analyses are given. The SS-MSMP is suggested for sparse data acquisition, in order to reconstruct analog and efficient signals via a small set of general measurements. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 26, 2016 Category: Bioinformatics Authors: Israa Shaker Tawfic, Sema Koc Kayhan Source Type: research

A Computer Tool for a Minimax Criterion in Binary Response and Heteroscedastic Simple Linear Regression Models
• A user-friendly applet to compute MV-optimal designs is provided.• The applet is applied to binary response and weighted linear regression models, for several standard weight functions.• The methodology for obtaining MV-optimal designs in a general compact interval design space is given.• Optimal designs for one binary model are also optimal for the corresponding weighted linear regression model.• Some illustrative examples will show a representation of MV-optimal designs in the Euclidean plane defined by the extremes of the design space. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 26, 2016 Category: Bioinformatics Authors: V. Casero –Alonso, J. López–Fidalgo, B. Torsney Source Type: research

Vessel segmentation and microaneurysm detection using discriminative dictionary learning and sparse representation
• Our method can diagnose Diabetic retinopathy through analyzing retinal image.• This method is based on discriminative dictionary learning and sparse representation.• Previous methods relied on fixed dictionary but we obtain dictionary via learning.• The results indicate that our method ach ieves high accuracy especially in abnormal image. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 25, 2016 Category: Bioinformatics Authors: Malihe Javidi, Hamid-Reza Pourreza, Ahad Harati Source Type: research

A dual stage adaptive thresholding (DuSAT) for automatic mass detection in mammograms
• Pre-processing using thresholding and region growing methods.• An optimal adaptive global threshold selection by maximizing between-class standard deviation through histogram peak analysis to obtain a coarse segmentation.• A window based adaptive local thresholding to obtain the fine segment ation of mass.• Proposed approach yields most satisfactory results to ground-truth segments.• The comparison is carried out in terms of TPF and FP/I to show the effectiveness. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 25, 2016 Category: Bioinformatics Authors: J. Anitha, J. Dinesh Peter, S. Immanuel Alex Pandian Source Type: research

Simulating the dynamics of lipid droplets in adipocyte differentiation
• The interaction between cellular organelles, like lipid droplets, can be numerically simulated.• Many interactions can be simulated in a very brief computational time.• Many different processes can be explored.• All the needed information, both theoretical and experimental, are provided in order to repeat the procedure. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 25, 2016 Category: Bioinformatics Authors: Federico Boschi, Vanni Rizzatti, Mauro Zamboni, Andrea Sbarbati Source Type: research

RUbioSeq+: a multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data
• RUbioSeq+, a multiplatform application for the integrated analysis of NGS data is presented.• Our software implements pipelines for the analysis of single nucleotide and copy-number variation, bisulfite-seq and ChIP-seq experiments, using well-established tools to perform these common tasks.• RUbioSeq+ also incorporates a new Graphical User Interface (GUI), designed for interdisciplinary research groups where bioinformaticians and biomedical researchers work together.• To our knowledge, there is no other current application with similar characteristics and such a number of automated w orkflows and utilities for N...
Source: Computer Methods and Programs in Biomedicine - October 25, 2016 Category: Bioinformatics Authors: Miriam Rubio-Camarillo, Hugo L ópez-Fernández, Gonzalo Gómez-López, Ángel Carro, José María Fernández, Coral Fustero Torre, Florentino Fdez-Riverola, Daniel Glez-Peña Source Type: research

WITHDRAWN: Determinants and development of a web-based prediction model for child mortality in Ethiopian local language using data mining technology
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 24, 2016 Category: Bioinformatics Authors: Brook Tesfaye, Suleman Atique, Noah Elias, Legesse Dibaba, Syed-Abdul Shabbir, Mihiretu Kebede Source Type: research

Detecting Retinal Microaneurysms and Hemorrhages with Robustness to the Presence of Blood Vessels
• Proposed filters do not give false positives on blood vessels.• Filters are applied on sub-images resulting after division of image using a grid.• Multiple kernel learning (MKL) combines detections at different grid sizes.• MKL performs better than any individual grid size. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 24, 2016 Category: Bioinformatics Authors: Ruchir Srivastava, Lixin Duan, Damon W.K. Wong, Jiang Liu, Tien Yin Wong Source Type: research

Determinants and development of a web-based prediction model for child mortality with Ethiopian local language using data mining technology
• Developed prediction model for child mortality.• Assessed Determinants of childhood mortality in Ethiopia.• Built a web-based application for childhood mortality prediction using Ethiopian local language.• Provided methods and models to assist health professionals in counseling. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 24, 2016 Category: Bioinformatics Authors: Brook Tesfaye, Suleman Atique, Noah Elias, Legesse Dibaba, Shabbir Syed-Abdul, Mihiretu Kebede Source Type: research

Collapsed Cone dose calculations for heterogeneous tissues in brachytherapy using Primary and Scatter Separation source data
• The manuscript reports details of a computing methodology for brachytherapy dose calculation. Brachytherapy is a form of radiotherapy using small, sealed radioactive sources. The computational method described in this manuscript is, since 2014, available in a commercial software for radiation tr eatment planning from Elekta AB (Stockholm, Sweden). Elekta's soft- and hardware for brachytherapy is developed and manufactured in Veenendal, the Netherlands (earlier under the name Nucletron) and is a large distributor of brachytherapy equipment (hard- and software). (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 23, 2016 Category: Bioinformatics Authors: Anders Ahnesj ö, Bob van Veelen, Åsa Carlsson Tedgren Source Type: research

The Application of a Decision Tree to Establish the Parameters Associated with Hypertension
• A major strength of the present study is that it was performed in a large number of samples and provides an appropriate vision regarding the application of decision tree for investigating predicators associated with hypertension in a representative sample of the Iran population.• In the curren t study, Hs-CRP was considered as a new component that has not been entered in existing models as a risk factor of hypertension until yet.• The new insight in this study was using blood count parameters as input variables. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - October 23, 2016 Category: Bioinformatics Authors: Maryam Tayefi, Habibollah Esmaeili, Maryam Saberi Karimian, Alireza Amirabadi Zadeh, Mahmoud Ebrahimi, Mohammad Safarian, Mohsen Nematy, Seyed Mohammad Reza Parizadeh, Gordon A. Ferns, Majid Ghayour-Mobarhan Source Type: research