Different quality of treatment in retroperitoneal sarcomas (RPS) according to hospital-case volume and surgeon-case volume: a retrospective regional analysis in Italy
ConclusionsIn HCV hospitals, sarcoma SCV may significantly influence RPS treatment quality. In low-volume centers surgical reports can often miss important prognostic issues and surgical quality is generally poor. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - February 28, 2018 Category: Cancer & Oncology Source Type: research
Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour
ConclusionsPleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - February 9, 2018 Category: Cancer & Oncology Source Type: research
Intraosseous papillary intralymphatic angioendothelioma (PILA): one new case and review of the literature
ConclusionsPILA can also occur in bone, albeit very rarely, and has to be considered in the differential diagnosis of vascular bone tumors. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - January 30, 2018 Category: Cancer & Oncology Source Type: research
Response to isolated limb perfusion and chemotherapy with epirubicin plus ifosfamide in a metastatic malignant ossifying fibromyxoid tumor
ConclusionsTo our knowledge, this is the first report of activity of soft tissue sarcoma-oriented chemotherapy in advanced OFMT. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 28, 2017 Category: Cancer & Oncology Source Type: research
Giant cell tumour of the distal radius/ulna: response to pre-operative treatment with short-term denosumab
ConclusionDistal forearm GCTB responds clinically, radiologically and histologically to a short course of pre-operative denosumab therapy, which has the potential to facilitate salvage surgery. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 30, 2017 Category: Cancer & Oncology Source Type: research
A retrospective cohort study of treatment patterns among patients with metastatic soft tissue sarcoma in the US
ConclusionChoice of regimen by LOT among patients with mSTS is varied; < 65% of patients in any LOT received the five most common regimens. Pazopanib, the only approved targeted therapy, is primarily used in second and later lines of therapy and is mostly given post docetaxel + gemcitabine. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 9, 2017 Category: Cancer & Oncology Source Type: research
Utility of VS38c in the diagnostic and prognostic assessment of osteosarcoma and other bone tumours/tumour-like lesions
ConclusionsOur findings show that VS38c is a sensitive but not specific diagnostic marker of osteosarcoma. Staining with VS38c identifies viable osteosarcoma cells, a feature which may be useful in the assessment of percentage tumour necrosis post-neoadjuvant chemotherapy. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - September 18, 2017 Category: Cancer & Oncology Source Type: research
Activity of anthracycline- and ifosfamide-based chemotherapy in a series of patients affected by advanced myxofibrosarcoma
ConclusionsThis retrospective analysis suggests that the combination of anthracyclines and ifosfamide is active in myxofibrosarcoma. In patients already treated with a combination of anthracyclines and ifosfamide, high-dose prolonged-infusion ifosfamide showed activity as well. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - August 22, 2017 Category: Cancer & Oncology Source Type: research
Radiation induced angiosarcoma of the breast: outcomes from a retrospective case series
ConclusionRIAS are rare, aggressive soft-tissue lesions with limited treatment options and high-rates of both local and systemic relapse. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - August 7, 2017 Category: Cancer & Oncology Source Type: research
Complete response of mediastinal clear cell sarcoma to pembrolizumab with radiotherapy
ConclusionThe complete clinical response observed in our patient suggests synergy between concurrent radiotherapy and PD1 blockade in CCS. This case and the striking parallels between CCS and melanoma indicate the need for prospective trials of immune checkpoint blockade combined with radiotherapy in this rare malignancy. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - July 14, 2017 Category: Cancer & Oncology Source Type: research
