A rare presentation of carcinosarcoma of the bone in a young female; response with gemcitabine and docetaxel
ConclusionsPrimary carcinosarcoma of the bone is an extremely rare malignancy. Early diagnosis is crucial as localized disease may be curable with resection. As shown in this case, combination chemotherapy with gemcitabine and docetaxel is a potential option in patients with unresectable or metastatic disease. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - July 1, 2019 Category: Cancer & Oncology Source Type: research
Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes
ConclusionsChondrosarcoma cell lines as well as primary tumors are variably radioresistant, particularly in case of a defective Rb pathway. Whether selection for radiotherapy can be based upon an intact Rb pathway should be further investigated. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 27, 2019 Category: Cancer & Oncology Source Type: research
Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours
ConclusionsUCP1 is strongly expressed in BAT but not WAT and is found in all hibernomas and a few pleomorphic liposarcomas but not in other adipose tumours. UCP1 expression in a few non-adipose soft tissue sarcomas may possibly reflect origin of tumour cells from a common mesenchymal stem cell precursor and/or developmental pathway. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 12, 2019 Category: Cancer & Oncology Source Type: research
Correction to: Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry
The legends for Figs. 3 and 5 of the article [1] incorrectly refer to an “all others group”. The corrected legends should read: (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 6, 2019 Category: Cancer & Oncology Source Type: research
Perspectives on treatment side effects in patients with metastatic gastrointestinal stromal tumour: a qualitative study
ConclusionsWe observed a gap between the biomedical perspective on disease that health professionals typically adopt and the individual experiences of patients living with metastatic GIST. For those patients who are living in limbo between having metastatic cancer and offered an effective treatment, a holistic view of health on the part of their healthcare providers seems crucial. A vital goal should hence be to improve communication between healthcare professionals and GIST patients so as to secure an individualised follow-up with guidance on coping with, and adapting to, their new normal.Trial registration The study was ...
Source: Clinical Sarcoma Research - April 29, 2019 Category: Cancer & Oncology Source Type: research
The challenge of finding new therapeutic avenues in soft tissue sarcomas
AbstractSoft tissue sarcomas are rare malignancies of mesenchymal origin comprising about 1% of all adult cancers. Systemic therapies for locally advanced and metastatic disease have been restricted for decades to very few effective and approved agents such as doxorubicin and ifosfamide. However, new therapeutic avenues including new drug developments and registrations such as trabectedin, pazopanib and eribulin as well as numerous clinical trial options have recently enriched the therapeutic armamentarium in the treatment of patients with advanced soft tissue sarcomas. The challenges and pitfalls of finding such new thera...
Source: Clinical Sarcoma Research - April 9, 2019 Category: Cancer & Oncology Source Type: research
Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry
ConclusionsIn our analysis, sunitinib and regorafenib significantly improved OS compared with patients who never received these agents. Our data also support the hypothesis that the use of KIT/PDGFRA inhibitors, including non-approved agents, has improved OS for patients with imatinib- and sunitinib-resistant GIST. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - April 1, 2019 Category: Cancer & Oncology Source Type: research
Genomic aberrations in cell cycle genes predict progression of KIT -mutant gastrointestinal stromal tumors (GISTs)
ConclusionOur results demonstrate that genomic events targeting cell cycle-related genes are associated with GIST progression to malignant disease. Based on this data, we propose a model for molecular pathogenesis of malignant GIST. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - March 4, 2019 Category: Cancer & Oncology Source Type: research
Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype
ConclusionsOur findings support the concept that AFX and PDS belong to a common tumor spectrum. We could demonstrate the diagnostic value of DNA-methylation profiling to delineating AFX/PDS from potential mimics. However, the assessment of certain histologic features remains crucial for separating PDS from AFX. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - February 14, 2019 Category: Cancer & Oncology Source Type: research
Long-term cure of soft tissue sarcoma with pegylated-liposomal doxorubicin after doxorubicin and ifosfamide failure
ConclusionsThis case illustrates the curative potential of PLD after failure of free doxorubicin and the absence of long term cardiotoxicity with PLD. As with all drugs, individual adjustment of dose and treatment interval is important. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - January 15, 2019 Category: Cancer & Oncology Source Type: research
Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment
ConclusionsPelvic dedifferentiated CS often presents at an advanced local or systemic stage and confers a poor prognosis. Achieving wide surgical margins (> 4 mm) provided the highest rate of long-term disease-free survival. Failing to achieve wide margins results in rapid disease recurrence, conferring deleterious consequences. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 14, 2018 Category: Cancer & Oncology Source Type: research
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases
ConclusionWhile surgical management of EMC with or without radiation therapy is still the preferable approach when feasible, small series support the use of tyrosine kinase inhibitors and possible new immunotherapies in selected patients. Basket trials focusing on diseases with unique genomic features such as EMC will hopefully provide a better understanding of new options for care. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 5, 2018 Category: Cancer & Oncology Source Type: research
A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas
ConclusionsOur study adds to the literature supporting the addition of mTOR inhibition to chemotherapy agents for the treatment of sarcomas, and proposes that a mechanism by which mTOR inhibition enhances the efficacy of chemotherapy may be through sensitizing the chemoresistant CSC population. Further study, ideally with pre- and post-therapy assessment of ALDH expression in tumor cells, is warranted.Trial registration The trial was registered on clinicaltrials.gov (NCT00949325) on 30 July 2009.http://www.editorialmanager.com/csrj/default.aspx (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 5, 2018 Category: Cancer & Oncology Source Type: research
Descending thoracic aortic aneurysm revealing metastasis of a soft tissue fibrosarcoma: a case report and review of the literature
ConclusionThe presence of an aneurysm in a patient with a sarcoma with a high potential for metastasis and poor cardiovascular risk factors should alert physicians. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - October 26, 2018 Category: Cancer & Oncology Source Type: research
Preoperative radiotherapy of soft-tissue sarcomas: surgical and radiologic parameters associated with local control and survival
ConclusionPreoperative radiotherapy of high-risk soft-tissue sarcomas allows for good local control rate at the expense of local wound complications, which are however manageable. Marginal excision is sufficient for local control. Absence of peritumoural oedema on MRI, as well as tumour size reduction following radiotherapy are associated to superior patient survival and can be used ass early prognostic factors. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - October 5, 2018 Category: Cancer & Oncology Source Type: research
