Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology
Abstract
This is the report of the 2nd Joint ENCCA/EuroSARC European Bone Sarcoma Network Meeting held in Leiden, The Netherlands, on 26-27 September 2013, bringing together preclinical and clinical investigators on bone sarcoma. The purpose of this workshop was to present the achievements of biological research and clinical trials in bone sarcomas and to stimulate crosstalk. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 1, 2014 Category: Cancer & Oncology Source Type: research
Trabectedin for desmoplastic small round cell tumours: a possible treatment option?
Conclusions
This report supports Trabectedin to be active and safe in pre-treated DSRCT patients. Further prospective and collaborative efforts are desirable to better define its role in the management of this disease. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - April 25, 2014 Category: Cancer & Oncology Source Type: research
Serum protein acidic and rich in cysteine (SPARC) as a prognostic marker in soft tissue sarcomas
Conclusions
SPARC expression is elevated in a significant proportion of STS specimens analyzed in this study, but it does not appear to correlate with specific STS histologies. Given our limited sample size, we cannot draw definitive conclusions regarding association of SPARC with STS subtype. Overall survival segregates strongly by degree of SPARC expression, with elevated expression being adverse. If validated in a larger study, our results suggest that trials in STS with agents potentially targeting SPARC, such as NAB-paclitaxel, should be stratified by SPARC expression level. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - January 31, 2014 Category: Cancer & Oncology Source Type: research
Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours
Abstract
Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT), are rare complications following organ/stem cell transplantation. Despite the mainly benign behaviour of PTSMT, alternative therapies are needed for those patients with progressive tumours. In tumours not approachable by surgery or reduction of immunosuppression, the angiogenic microenvironment might be a potential target of therapy, an approach that is well utilised in other soft tissue neoplasms. In a previous study, we evaluated the expression of EBV-related genes and the microRNA profile in PTSMT, but so far ...
Source: Clinical Sarcoma Research - January 7, 2014 Category: Cancer & Oncology Source Type: research
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study
Conclusions
By contrast to what reported so far, anthracycline-based chemotherapy is active in a distinct proportion of EMC patients. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 18, 2013 Category: Cancer & Oncology Source Type: research
Intra-patient dose escalation in Ewing’s sarcoma treated with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide and etoposide: a retrospective review
Conclusions
DE is deliverable without increased adverse outcomes. Males have less myelosuppression during VDC, and should be especially considered for DE. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 10, 2013 Category: Cancer & Oncology Source Type: research
Pazopanib is an active treatment in desmoid tumour/aggressive fibromatosis
Conclusions
Pazopanib is an active treatment in DT/AF. It is the first time this has been reported. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 26, 2013 Category: Cancer & Oncology Source Type: research
Desmoplastic small round cell tumour: characteristics and prognostic factors of 41 patients and review of the literature
Conclusions
DSRCT is a rare but often fatal disease that mainly affects younger male patients. Those with intra-abdominal DSRCT have a poorer prognosis, although surgical resection for localised disease and radiotherapy in the metastatic setting are associated with improved survival. A patient’s age, gender and size of presenting tumour do not have prognostic significance. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 26, 2013 Category: Cancer & Oncology Source Type: research
Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations
Conclusions
This exploratory analysis offers novel insights into gastrointestinal stromal tumor etiology and provides a starting point for future studies of genetic and environmental risk factors for the disease. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - October 26, 2013 Category: Cancer & Oncology Source Type: research
The attitudes of people with sarcoma and their family towards genomics and incidental information arising from genetic research
Conclusions
The only difference between the study groups was the decreased likelihood of family members being highly positive about genetic testing. This may be important if predictive testing for sarcoma becomes available. Generally ISKS research participants supported the notion of returning incidental genetic information to research participants. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - July 30, 2013 Category: Cancer & Oncology Source Type: research
Mesenchymal stem cell transformation and sarcoma genesis
Abstract
MSCs are hypothesized to potentially give rise to sarcomas after transformation and therefore serve as a good model to study sarcomagenesis. Both spontaneous and induced transformation of MSCs have been reported, however, spontaneous transformation has only been convincingly shown in mouse MSCs while induced transformation has been demonstrated in both mouse and human MSCs. Transformed MSCs of both species can give rise to pleomorphic sarcomas after transplantation into mice, indicating the potential MSC origin of so-called non-translocation induced sarcomas. Comparison of expression profiles a...
Source: Clinical Sarcoma Research - July 23, 2013 Category: Cancer & Oncology Source Type: research
MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype
Abstract
Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT) are rare complications. In our previous molecular analysis, we have evaluated the expression of regulatory microRNA which are known to be EBV-related (miR-146a and miR-155) but found no deregulation in PTSMT. In this current analysis, we aimed to characterize the expression profiles of several hundred microRNA. Tissue samples from PTSMT and uterine leiomyomas were analysed by quantitative real-time PCR for the expression of 365 mature microRNA. PTSMT and leiomyomas share a highly similar microRNA profile, e.g. str...
Source: Clinical Sarcoma Research - July 6, 2013 Category: Cancer & Oncology Source Type: research
