Serum protein acidic and rich in cysteine (SPARC) as a prognostic marker in soft tissue sarcomas

Conclusions SPARC expression is elevated in a significant proportion of STS specimens analyzed in this study, but it does not appear to correlate with specific STS histologies. Given our limited sample size, we cannot draw definitive conclusions regarding association of SPARC with STS subtype. Overall survival segregates strongly by degree of SPARC expression, with elevated expression being adverse. If validated in a larger study, our results suggest that trials in STS with agents potentially targeting SPARC, such as NAB-paclitaxel, should be stratified by SPARC expression level.
Source: Clinical Sarcoma Research - Category: Cancer & Oncology Source Type: research