Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors
AbstractPost-transplant smooth muscle tumors (PTSMTs) are rare mesenchymal neoplasms which occur after solid organ or haematopoietic stem cell transplantation. PTSMT typically consist of Epstein –Barr-virus (EBV)+ smooth muscle-like cells and show an intermediate malignancy. Their main occurrences are visceral organs, especially the liver, but intracranial appearances are described and associated with a poor prognosis. EBV drives the growth of PTSMT; however, the underlying molecular mech anisms still remain unclear. Gene expression analysis of a set of morphologically similar tumors (leiomyomas, leiomyosarcomas, angiole...
Source: Clinical Sarcoma Research - June 4, 2018 Category: Cancer & Oncology Source Type: research
Aggressive fibromatosis response to tamoxifen: lack of correlation between MRI and symptomatic response
ConclusionsNo relationship was identified between symptomatic benefit and response by RECIST 1.1 on MRI. Prospective studies in AF should incorporate endpoints focusing on patient symptoms. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 14, 2018 Category: Cancer & Oncology Source Type: research
Treatment patterns and survival among older adults in the United States with advanced soft-tissue sarcomas
ConclusionsAlthough previous studies of younger populations reported anthracycline-based therapy predominated in first line, our study of older advanced STS patients found that docetaxel plus gemcitabine was most commonly used. Despite variation by histologic category, prognosis remains poor for older adult patients with advanced STS. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - May 3, 2018 Category: Cancer & Oncology Source Type: research
Smoking is predictive of poorer distant metastasis-free and progression free-survival in soft tissue sarcoma patients treated with pre-operative radiotherapy or chemoradiotherapy
ConclusionsCurrent smokers and patients with a significant smoking history demonstrated decreased DMFS and PFS in STS patients treated with pre-operative RT. Smoking may cause immunologic compromise and therefore lead to higher rates of progression and distant metastasis. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - April 16, 2018 Category: Cancer & Oncology Source Type: research
Retrospective audit of 957 consecutive 18 F-FDG PET –CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma
ConclusionsPET –CT in high-grade bone and soft tissue sarcoma can add significant benefit to routine CT/MRI staging. Further prospective and multi-centre evaluation of PET–CT is warranted to determine the actual predictive value and cost-effectiveness of PET–CT in directing clinical management of clinically complex and heterogeneous high-grade sarcomas. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - April 9, 2018 Category: Cancer & Oncology Source Type: research
Unicentric epithelioid hemangioendothelioma of the calcaneus: a case report and review of literature
ConclusionThis case has clinical follow-up greater than 2 years post-operatively and could be a guide for treatment of a rare disorder with a substantial paucity of literature. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - April 6, 2018 Category: Cancer & Oncology Source Type: research
Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92
ConclusionsUnexpected differences in EFS and OS occurred between two patient cohorts recruited within an international randomised trial. Failure to select or deliver appropriate local treatment modalities for Ewing ’s sarcoma may compromise chances of cure.Trial registration Supported by Deutsche Krebshilfe (Grants No. DKH M43/92/J ü2 and DKH 70-2551 Jü3), and European Union Biomedicine and Health Programme (Grants No. BMH1-CT92-1341 and BMH4-983956), and Cancer Research United Kingdom. Clinical trial information can be found for the following: NCT0000251 (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - March 30, 2018 Category: Cancer & Oncology Source Type: research
The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma
ConclusionAnalysis of WES of fresh tumour specimens via a bioinformatics pipeline may identify potential actionable chemotherapy agents. Further research into this field may lead to the development of personalized cancer therapy for sarcoma. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - March 8, 2018 Category: Cancer & Oncology Source Type: research
