Anti-CD73 and Anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer
Approximately 75% of ovarian cancer is diagnosed once metastasis to the peritoneal cavity has occurred. A large proportion of patients eventually develop platinum-resistive tumors, which are considered terminal. In order to provide an alternative a novel fusion protein, mCTH-ANXA5, has been developed for the treatment of recurrent, metastatic ovarian cancer. The fusion protein combines annexin V (ANXA5), an ovarian tumor and tumor vasculature targeting protein, with mutated cystathionine gamma-lyase (mCTH), an enzyme that converts selenomethionine (SeMet) into toxic methylselenol, which generates reactive oxygen species an...
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Needa A. Virani, Elangovan Thavathiru, Patrick McKernan, Kathleen Moore, Doris M. Benbrook, Roger G. Harrison Tags: Original Articles Source Type: research
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression
Aberrant Wnt/ β-catenin signaling is a common event during human colorectal cancer (CRC) development. Previously, we characterized members of the L1 family of cell adhesion receptors as targets of β-catenin-LEF1/TCF transactivation that are expressed at the invasive CRC tissue edge. Overexpression of L1 in CRC cells confers enhanced motility, tumorigenesis and liver metastasis. We identified several downstream targets of L1-mediated signaling that are considered key intestinal stem cell signature genes. (Source: Cancer Letters)
Source: Cancer Letters - March 15, 2018 Category: Cancer & Oncology Authors: Sayon Basu, Nancy Gavert, Thomas Brabletz, Avri Ben-Ze ’ev Tags: Original Articles Source Type: research
Corrigendum to ‘Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells’ [Cancer letters, 2013, 330(1): 49–56]
The authors regret that an error occurred in Fig. 7. The correct legend of Fig. 7 is: Effects of ZnPc on MMP (ΔΨm) of HepG2 cells. ΔΨm was analyzed by flow cytometry in HepG2 cells (A). Treatment of HepG2 cells with ZnPc (0.25, 0.5 and 1 μM) resulted in a concentration-dependent decrease in mitochondrial ΔΨm (B). Results are expressed as the percent change in ΔΨm of the treated cells compared to the untreated control. Statistical difference from controls: *P (Source: Cancer Letters)
Source: Cancer Letters - March 14, 2018 Category: Cancer & Oncology Authors: Jingwei Shao, Yongchao Dai, Wenna Zhao, Jingjing Xie, Jinping Xue, Jianhui Ye, Lee Jia Source Type: research
15-Deoxy- Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136
15-Deoxy- Δ12,14-prostaglandin J2 (15d-PGJ2), one of the terminal products of cyclooxygenase-2-catalized arachidonic acid metabolism, has been shown to stimulate breast cancer cell proliferation and migration through Akt activation, but the underlying mechanisms remain poorly understood. In the present study , we investigated the effects of 15d-PGJ2 on the activity of PTEN, the inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt axis, in human breast cancer (MCF-7) cells. Since the α,β-unsaturated carbonyl moiety in the cyclopentenone ring of 15d-PGJ2 is electrophilic, we hypothesized that 15d-PGJ2- induced Akt phosph...
Source: Cancer Letters - March 14, 2018 Category: Cancer & Oncology Authors: Jinyoung Suh, Do-Hee Kim, Eun-Hee Kim, Sin-Aye Park, Jong-Min Park, Jeong-Hoon Jang, Su-Jung Kim, Hye-Kyung Na, Nam-Doo Kim, Nam-Jung Kim, Young Ger Suh, Young-Joon Surh Tags: Original Articles Source Type: research
Leptin in autoimmune mechanisms of systemic rheumatic diseases
In the last two decades, white adipose tissue (WAT) has been recognized as a key actor of many physiological and pathological conditions. WAT is able to produce mediators, named “adipokines”, which may affect systemic homeostasis. In particular, leptin is not only involved in appetite and energy metabolism, but also in immune system. Increasing evidence established that leptin can regulate both innate and adaptive immunity mainly with pro-inflammatory effects but also, to a lesser extent, with anti-inflammatory features. (Source: Cancer Letters)
Source: Cancer Letters - March 13, 2018 Category: Cancer & Oncology Authors: Luca Navarini, Domenico Paolo Emanuele Margiotta, Marta Vadacca, Antonella Afeltra Tags: Mini-review Source Type: research
