The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression

Aberrant Wnt/ β-catenin signaling is a common event during human colorectal cancer (CRC) development. Previously, we characterized members of the L1 family of cell adhesion receptors as targets of β-catenin-LEF1/TCF transactivation that are expressed at the invasive CRC tissue edge. Overexpression of L1 in CRC cells confers enhanced motility, tumorigenesis and liver metastasis. We identified several downstream targets of L1-mediated signaling that are considered key intestinal stem cell signature genes.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research