ARID1A ablation leads to Multiple Drug Resistance in ovarian cancer via transcriptional activation of MRP2
Multiple Drug Resistance (MDR) of ovarian cancer is a severe trouble for clinical treatment and always attributes to a bad prognosis. AT-rich interaction domain 1 A (ARID1A) has been recognized as a bona fide tumor suppressor gene in recent years, with the highest mutation rate in ovarian cancer. Previous study illustrated that ARID1A expression is negatively correlated with chemoresistance of ovarian cancer cases. However, the specific role of ARID1A in c hemoresistance of ovarian cancer remains elusive. (Source: Cancer Letters)
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Qingyu Luo, Xiaowei Wu, Yiping Zhang, Tong Shu, Fang Ding, Hongyan Chen, Pengfei Zhao, Wan Chang, Xiaolin Zhu, Zhihua Liu Tags: Original Articles Source Type: research
Editorial Board
(Source: Cancer Letters)
Source: Cancer Letters - April 12, 2018 Category: Cancer & Oncology Source Type: research
Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells
Thymoquinone (TQ), the predominant bioactive constituent present in black cumin (Nigella sativa), exerts tumor suppressive activity against a wide variety of cancer cells. Cellular senescence, characterized by stable and long term loss of proliferative capacity, acts as a potent tumor suppressive mechanism. Here, we provide evidence for the first time that TQ suppresses growth of glioma cells by potentially inducing the expression of prostate apoptosis response-4 (Par-4) tumor suppressor protein. (Source: Cancer Letters)
Source: Cancer Letters - April 12, 2018 Category: Cancer & Oncology Authors: Karthikeyan Subburayan, Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Sehamuddin Galadari Tags: Original Articles Source Type: research
HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression
We previously reported that HOXB9 is overexpressed in colon cancer and predicts a favourable patient outcome, which is opposite to the tumour-promoting role of HOXB9 in other cancers. We hypothesized that HOXB9 acetylation may account for its inhibitory role in colon cancer. We aim to examine the role of acetylated HOXB9 in colon cancer cells and patients. The AcK27-HOXB9 levels in colon cancer cells and patients were analysed by Western blot analysis and immunohistochemistry separately. Correlation between AcK27-HOXB9 expression and patient survival was assessed by Kaplan –Meier analysis. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Jiagui Song, Tianzhuo Wang, Weizhi Xu, Peng Wang, Junhu Wan, Yunling Wang, Jun Zhan, Hongquan Zhang Tags: Original Articles Source Type: research
Residential radon and small cell lung cancer. A systematic review
Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the effect of residential radon exposure on the risk of small cell lung cancer (SCLC) in general population and miners through a systematic review applying predefined inclusion and exclusion criteria. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Ángeles Rodríguez-Martínez, María Torres-Durán, Juan M. Barros-Dios, Alberto Ruano-Ravina Tags: Mini-review Source Type: research
Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Yuhang Zhou, Tingting Huang, Jinglin Zhang, Alfred S.L. Cheng, Jun Yu, Wei Kang, Ka Fai To Tags: Mini-review Source Type: research
HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression
We previously reported that HOXB9 is overexpressed in colon cancer and predicts a favourable patient outcome, which is opposite to the tumour-promoting role of HOXB9 in other cancers. We hypothesized that HOXB9 acetylation may account for its inhibitory role in colon cancer. We aim to examine the role of acetylated HOXB9 in colon cancer cells and patients. The AcK27-HOXB9 levels in colon cancer cells and patients were analysed by Western blot analysis and immunohistochemistry separately. Correlation between AcK27-HOXB9 expression and patient survival was assessed by Kaplan –Meier analysis. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Jiagui Song, Tianzhuo Wang, Weizhi Xu, Peng Wang, Junhu Wan, Yunling Wang, Jun Zhan, Zhang Hongquan Tags: Original Articles Source Type: research
Residential radon and small cell lung cancer. A systematic review
Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the effect of residential radon exposure on the risk of small cell lung cancer (SCLC) in general population and miners through a systematic review applying predefined inclusion and exclusion criteria. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Ángeles Rodríguez-Martínez, María Torres-Durán, Juan M. Barros-Dios, Alberto Ruano-Ravina Tags: Mini-review Source Type: research
Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. (Source: Cancer Letters)
Source: Cancer Letters - April 11, 2018 Category: Cancer & Oncology Authors: Yuhang Zhou, Tingting Huang, Jinglin Zhang, Alfred S.L. Cheng, Jun Yu, Wei Kang, Ka Fai To Tags: Mini-review Source Type: research
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma
The transcription factor c-Myc is a key driver for hepatocellular carcinomas (HCCs), while the polycombrepressive complex 2 (PRC2) subunit EZH2 is an essential biomarker of HCC. c-Myc epigenetically silences tumor suppressors by recruiting PRC2 and inducing methylation of histone H3 lysine 27. However, it remains elusive how they are regulated in HCC. We found here that microRNA-26a (miR-26a) suppresses c-Myc, a classical Wnt pathway target gene, by targeting the Wnt pathway coactivator, cyclin-dependent kinase 8 (CDK8); miR-26a also directly targets and inhibits EZH2. (Source: Cancer Letters)
Source: Cancer Letters - April 10, 2018 Category: Cancer & Oncology Authors: Xiang Zhang, Xiao Zhang, Ting Wang, Lei Wang, Zhijun Tan, Wei Wei, Bo Yan, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang, Lintao Jia Tags: Original Articles Source Type: research
Emerging landscape of circular RNAs in lung cancer
Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. (Source: Cancer Letters)
Source: Cancer Letters - April 10, 2018 Category: Cancer & Oncology Authors: Wei Hu, Zhuo-Yue Bi, Zhen-Long Chen, Cong Liu, Lin-Lin Li, Feng Zhang, Qun Zhou, Wei Zhu, Yang-Yi-Yan Song, Bo-Tao Zhan, Qian Zhang, Yong-Yi Bi, Cheng-Cao Sun, De-Jia Li Tags: Mini-review Source Type: research
BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC
Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. While partial or complete tumor regression can be achieved in patients, particularly with cisplatin-based strategies, these initial responses are frequently short-lived and are followed by tumor relapse and chemoresistance. Identifying the root of cisplatin resistance in NSCLC and elucidating the mechanism(s) of tumor relapse, is of critical importance in order to determine the point of therapeutic failure, which in turn, will aid the discovery of novel therapeutics, new combination strategies and a strategy to enhance the effic...
Source: Cancer Letters - April 10, 2018 Category: Cancer & Oncology Authors: Lauren MacDonagh, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr Tags: Original Articles Source Type: research
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma
Overexpressed c-Myc and EZH2 usually mean high malignancy in cancers. Most of mortality from cancer is attributable to metastasis. MicroRNAs(miRNAs), like transcription factors, can regulate hundreds of genes. Here, we identify microRNA-26a (miR-26a) suppresses EZH2 and c-Myc by targeting EZH2 and CDK8 in Wnt pathway. MiR-26a is a well-known tumor-suppressive miRNA in multiple cancers, but how it is downregulated in hepatocellular carcinoma (HCC) is still unclear. Here, we disclose miR-26a is epigenetic silenced by a c-Myc-mediated PRC2-depandent way in HCC. (Source: Cancer Letters)
Source: Cancer Letters - April 10, 2018 Category: Cancer & Oncology Authors: Xiang Zhang, Xiao Zhang, Ting Wang, Lei Wang, Zhijun Tan, Wei Wei, Bo Yan, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang, Lintao Jia Tags: Original Articles Source Type: research
Emerging landscape of circular RNAs in lung cancer
Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. (Source: Cancer Letters)
Source: Cancer Letters - April 10, 2018 Category: Cancer & Oncology Authors: Wei Hu, Zhuo-Yue Bi, Zhen-Long Chen, Cong Liu, Lin-Lin Li, Feng Zhang, Qun Zhou, Wei Zhu, Yang-Yi-Yan Song, Bo-Tao Zhan, Qian Zhang, Yong-Yi Bi, Cheng-Cao Sun, De-Jia Li Tags: Mini-review Source Type: research
