Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity

Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Mini-review Source Type: research