Editorial Board
(Source: Cancer Letters)
Source: Cancer Letters - April 26, 2018 Category: Cancer & Oncology Source Type: research
Inhibition of NF- κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression
The introduction of temozolomide (TMZ) has improved chemotherapy for malignant gliomas. However, many gliomas are refractory to TMZ, so there is a pressing need for more effective therapeutic options. Here we demonstrated that glioma specimens and cell lines have constitutively high levels of nuclear factor κB (NF-κB) activity. Notably, the expression levels of this transcription factor correlated with malignant grades in glioblastoma multiforme (GBM) and inversely correlated with overall survival. (Source: Cancer Letters)
Source: Cancer Letters - April 26, 2018 Category: Cancer & Oncology Authors: Zhiyun Yu, Yong Chen, Shiqiang Wang, Pengliang Li, Guangtong Zhou, Yongjie Yuan Tags: Original Articles Source Type: research
DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer
The acquisition of resistance is a major obstacle to the clinical use of platinum drugs for ovarian cancer treatment. Increase of DNA damage response is one of major mechanisms contributing to platinum-resistance. However, how DNA damage response is regulated in platinum-resistant ovarian cancer cells remains unclear. Using quantitative high throughput combinational screen (qHTCS) and RNA-sequencing (RNA-seq), we show that dual oxidase maturation factor 1 (DUOXA1) is overexpressed in platinum-resistant ovarian cancer cells, resulting in over production of reactive oxygen species (ROS). (Source: Cancer Letters)
Source: Cancer Letters - April 25, 2018 Category: Cancer & Oncology Authors: Yunxiao Meng, Chi-Wei Chen, Mingo M.H. Yung, Wei Sun, Jing Sun, Zhuqing Li, Jing Li, Zongzhu Li, Wei Zhou, Stephanie S. Liu, Annie N.Y. Cheung, Hextan Y.S. Ngan, John C. Braisted, Yan Kai, Weiqun Peng, Alexandros Tzatsos, Yiliang Li, Zhijun Dai, Wei Zheng Tags: Original Articles Source Type: research
Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin
The signaling pathway driven by p38 and MAPKAPK2 alias MK2 is activated as part of stress responses, and these kinases represent attractive drug targets for cancer therapy. However, seemingly conflicting results were obtained when assessing the role of MK2 in chemotherapy. MK2 inhibitors were reported to either enhance or diminish the chemosensitivity of cancer cells. Here we show that this strongly depends on the particular chemotherapeutic drug. Two different MK2 inhibitors increased the proliferating fraction of pancreatic cancer-derived cells upon treatment with gemcitabine, whereas no consistent protection against cis...
Source: Cancer Letters - April 25, 2018 Category: Cancer & Oncology Authors: Yizhu Li, Frederik K öpper, Matthias Dobbelstein Tags: Original Articles Source Type: research
Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT
In this study, we found Pseudolaric acid B (PAB) inhibited the viabilities of glioma cells in vitro and in vivo, which was accompanied by abnormal increases of intracellular ferrous iron, H2O2 and lipid peroxidation, as well as depletion of GSH and cysteine. In vitro studies revealed that the lipid peroxidation and the cell death caused by PAB were both inhibited by iron chelator deferoxamine, but exacerbated by supplement of ferric ammonium citrate. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Zongqi Wang, Ye Ding, Xuanzhong Wang, Shan Lu, Chongcheng Wang, Chuan He, Lei Wang, Meihua Piao, Guangfan Chi, Yinan Luo, Pengfei Ge Tags: Original Articles Source Type: research
Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14
In this study, we found that hsa-miR-124a was downregulated during spheroid formation of the NSCLC cell lines SPC-A1 and NCI-H1650 and NSCLC tissues compared with normal lung cells and tissues. Patients with lower hsa-miR-124a expression had shorter overall survival (OS) and progression free survival (PFS). (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Fei Yu, Ji-Bin Liu, Zhi-Jun Wu, Wen-Ting Xie, Xiao-Jun Zhong, Li-Kun Hou, Wei Wu, Hai-Min Lu, Xiao-Hui Jiang, Jun-Jian Jiang, Zi-Yang Cao, Gu-Jun Cong, Min-Xin Shi, Cheng-You Jia, Gai-Xia Lu, Ying-Chun Song, Li Chai, Zhong-Wei Lv, Chun-Yan Wu, Yu-Shui Ma, Tags: Original Articles Source Type: research
Mutations in the Estrogen Receptor Alpha Hormone Binding Domain Promote Stem Cell Phenotype through Notch Activation in Breast Cancer Cell Lines
The detection of recurrent mutations affecting the hormone binding domain (HBD) of estrogen receptor alpha (ER α/ESR1) in endocrine therapy-resistant and metastatic breast cancers has prompted interest in functional characterization of these genetic alterations. Here, we explored the role of HBD-ESR1 mutations in influencing the behaviour of breast cancer stem cells (BCSCs), using various BC cell lines stab ly expressing wild-type or mutant (Y537 N, Y537S, D538G) ERα. Compared to WT-ERα clones, mutant cells showed increased CD44+/CD24- ratio, mRNA levels of stemness genes, Mammosphere Forming Efficiency (MFE), Self-Re...
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: L. Gelsomino, S. Panza, C. Giordano, I. Barone, G. Gu, E. Spina, S. Catalano, S. Fuqua, S. And ò Tags: Original Articles Source Type: research
PA28 γ acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma
PA28 γ promotes tumor development and progression and is suggested to play a role in tumor angiogenesis, but the molecular mechanisms have not been investigated. Here, we found that PA28γ enhanced the ability of OSCC cells to promote the migration, invasion, and tube formation of HUVECs and promoted tu mor-induced angiogenesis in xenograft mice models in vivo. Then, a mechanism study revealed that the expression and secretion of IL-6 and CCL2 were dependent on PA28γ expression. Furthermore, blocking IL-6 or CCL2 or the transcription factor NF-κB induced the inhibition of tube formation in HUVECs co-cultured with PA28γ...
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Sai Liu, Dongjuan Liu, Xin Zeng, Jiongke Wang, Jiajia Liu, Junxin Cheng, Kexin Lei, Hetian Bai, Ning Ji, Min Zhou, Lu Jiang, Hongxia Dan, Jing Li, Qianming Chen Tags: Original Articles Source Type: research
Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells
In the present study, we show that pharmacological repression by the Hedgehog (Hh) pathway inhibitor (HPI) GANT61 induces expression of the proapoptotic protein Noxa in TP53-mutated embryonal pediatric tumor cells driven by Hh signaling (i.e. rhabdomyosarcoma (RMS) and medulloblastoma (MB)). Similarly, genetic silencing of Gli1 by siRNA causes increased Noxa mRNA and protein levels, while overexpression of Gli1 results in decreased Noxa expression. Furthermore, TAp73 mRNA and protein levels are increased upon Gli1 knockdown, while Gli1 overexpression reduces TAp73 mRNA and protein levels. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Michael Torsten Meister, Cathinka Boedicker, Thomas Klingebiel, Simone Fulda Tags: Original Articles Source Type: research
Knockdown of TGF- β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells
In this study, we found that human umbilical cord MSC-conditioned medium (MSC-CM) promotes EMT, invasion, and migration, yet inhibits proliferation and promotes apoptosis of lung cancer cells. The EMT-promoting effect of MSCs was mediated by exosomes derived from MSCs (MSC-exo) and eliminated by inhibiting exosome release. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Xiaoyin Zhao, Xue Wu, Manqing Qian, Yuxian Song, Dongliang Wu, Wen Zhang Tags: Original Articles Source Type: research
miR-19a-mediated downregulation of RhoB inhibits the dephosphorylation of AKT1 and induces osteosarcoma cell metastasis
Osteosarcoma is a primary malignancy that develops in bone, along with serious recurrence and metastasis. As an isoform of Rho family GTPases, RhoB could suppress cell proliferation, invasion, and anti-angiogenesis. But it is not clear how RhoB involves in tumor metastasis. Here we found that expression of RhoB was decreased in osteosarcoma primary samples and cell lines. Ectopic expression of RhoB restrains the migration of osteosarcoma cells in vitro and in vivo, and induces osteosarcoma cell apopotsis. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Qingping Zou, Xin Xiao, Ying Liang, Lina Peng, Zheng Guo, Wei Li, Wenqiang Yu Tags: Original Articles Source Type: research
miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP)
The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to multidrug resistance in solid tumors is unknown. Here, we investigated CHOP expression in tumor tissues form 69 lung cancer patients, finding that deficient CHOP expression is associated with poor prognosis. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Wenfeng Tan, Yi Liao, Yang Qiu, Hongxiang Liu, Deli Tan, Tao Wu, Meng Tang, Shixin Zhang, Haidong Wang Tags: Original Articles Source Type: research
Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT
In this study, we found Pseudolaric acid B (PAB) inhibited the viabilities of glioma cells in vitro and in vivo, which was accompanied by abnormal increases of intracellular ferrous iron, H2O2 and lipid peroxidation, as well as depletion of GSH and cysteine. In vitro studies revealed that the lipid peroxidation and the cell death caused by PAB were both inhibited by iron chelator deferoxamine, but exacerbated by supplement of ferric ammonium citrate. (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Zongqi Wang, Ye Ding, Xuanzhong Wang, Shan Lu, Chongcheng Wang, Chuan He, Lei Wang, Meihua Piao, Guangfan Chi, Yinan Luo, Pengfei Ge Tags: Original Articles Source Type: research
Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14
In this study, we found that hsa-miR-124a was downregulated during spheroid formation of the NSCLC cell lines SPC-A1 and NCI-H1650 and NSCLC tissues compared with normal lung cells and tissues. Patients with lower hsa-miR-124a expression had shorter overall survival (OS) and progression free survival (PFS). (Source: Cancer Letters)
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Fei Yu, Ji-Bin Liu, Zhi-Jun Wu, Wen-Ting Xie, Xiao-Jun Zhong, Li-Kun Hou, Wei Wu, Hai-Min Lu, Xiao-Hui Jiang, Jun-Jian Jiang, Zi-Yang Cao, Gu-Jun Cong, Min-Xin Shi, Cheng-You Jia, Gai-Xia Lu, Ying-Chun Song, Li Chai, Zhong-Wei Lv, Chun-Yan Wu, Yu-Shui Ma, Tags: Original Articles Source Type: research
Mutations in the Estrogen Receptor Alpha Hormone Binding Domain Promote Stem Cell Phenotype through Notch Activation in Breast Cancer Cell Lines
The detection of recurrent mutations affecting the hormone binding domain (HBD) of estrogen receptor alpha (ER α/ESR1) in endocrine therapy-resistant and metastatic breast cancers has prompted interest in functional characterization of these genetic alterations. Here, we explored the role of HBD-ESR1 mutations in influencing the behaviour of breast cancer stem cells (BCSCs), using various BC cell lines stab ly expressing wild-type or mutant (Y537 N, Y537S, D538G) ERα. Compared to WT-ERα clones, mutant cells showed increased CD44+/CD24- ratio, mRNA levels of stemness genes, Mammosphere Forming Efficiency (MFE), Self-Re...
Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: L. Gelsomino, S. Panza, C. Giordano, I. Barone, G. Gu, E. Spina, S. Catalano, S. Fuqua, S. And ò Tags: Original Articles Source Type: research
