Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14

In this study, we found that hsa-miR-124a was downregulated during spheroid formation of the NSCLC cell lines SPC-A1 and NCI-H1650 and NSCLC tissues compared with normal lung cells and tissues. Patients with lower hsa-miR-124a expression had shorter overall survival (OS) and progression free survival (PFS).

Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Fei Yu, Ji-Bin Liu, Zhi-Jun Wu, Wen-Ting Xie, Xiao-Jun Zhong, Li-Kun Hou, Wei Wu, Hai-Min Lu, Xiao-Hui Jiang, Jun-Jian Jiang, Zi-Yang Cao, Gu-Jun Cong, Min-Xin Shi, Cheng-You Jia, Gai-Xia Lu, Ying-Chun Song, Li Chai, Zhong-Wei Lv, Chun-Yan Wu, Yu-Shui Ma, Tags: Original Articles Source Type: research