miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP)

The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to multidrug resistance in solid tumors is unknown. Here, we investigated CHOP expression in tumor tissues form 69 lung cancer patients, finding that deficient CHOP expression is associated with poor prognosis.

Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Wenfeng Tan, Yi Liao, Yang Qiu, Hongxiang Liu, Deli Tan, Tao Wu, Meng Tang, Shixin Zhang, Haidong Wang Tags: Original Articles Source Type: research