Leptin in autoimmune mechanisms of systemic rheumatic diseases

In the last two decades, white adipose tissue (WAT) has been recognized as a key actor of many physiological and pathological conditions. WAT is able to produce mediators, named “adipokines”, which may affect systemic homeostasis. In particular, leptin is not only involved in appetite and energy metabolism, but also in immune system. Increasing evidence established that leptin can regulate both innate and adaptive immunity mainly with pro-inflammatory effects but also, to a lesser extent, with anti-inflammatory features.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Mini-review Source Type: research