Patient engagement and patient-centred care in the management of advanced chronic kidney disease and chronic kidney failure
Abstract Purpose The purpose of this article is to review the current status of patient-centred care (PCC) and patient engagement (PE) in the management of patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD), to identify some of the barriers that exist to the achievement of PCC and PE, and to describe how these barriers can be overcome. Sources of information The review is based on the professional experience of one of the authors (RB) as a...
Source: Canadian Journal of Kidney Health and Disease - October 21, 2014 Category: Urology & Nephrology Source Type: research

Use of a national continuing medical education meeting to provide simulation-based training in temporary hemodialysis catheter insertion skills: a pre-test post-test study
Conclusions Despite most participants reporting having previously inserted NTHCs in clinical practice, none met the MPS at baseline; this suggests their prior training may have been inadequate. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - October 14, 2014 Category: Urology & Nephrology Source Type: research

Canadian Organ Replacement Register (CORR): reflecting the past and embracing the future
Conclusion As the number of people treated for end-stage organ failure grows, so does the importance of understanding their treatment and outcomes. In 2014, CORR continues to evolve and support the important information need to advance ESRD research and clinical practice. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - October 11, 2014 Category: Urology & Nephrology Source Type: research

Is it ethical to prescribe generic immunosuppressive drugs to renal transplant patients?
Abstract Purpose of the review This review was conducted to determine the ethical acceptability of prescribing generic immunosuppressive drugs to renal transplant patients. Sources of information The literature search was conducted using Pubmed and Google Scholar. Findings The use of generic immunosuppressive drugs (ISDs) in transplantation is a controversial topic. There is a consensus amo...
Source: Canadian Journal of Kidney Health and Disease - September 9, 2014 Category: Urology & Nephrology Source Type: research

Fluid balance, change in serum creatinine and urine output as markers of acute kidney injury post cardiac surgery: an observational study
Conclusions Oliguria and positive fluid balance is associated with a trend towards longer LOS as compared to oliguria alone. Fluid balance may therefore be a useful marker of AKI, in addition to urine output and serum creatinine. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - September 2, 2014 Category: Urology & Nephrology Source Type: research

The three-year incidence of major hemorrhage among older adults initiating chronic dialysis
Conclusions Many older patients who initiate chronic dialysis will be hospitalized with hemorrhage and receive related procedures over the subsequent three years. Despite greater age and co-morbidity over the last decade this incidence has not changed. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - September 2, 2014 Category: Urology & Nephrology Source Type: research

Bridging the gap: a Canadian perspective on translational kidney research
We present the following examples of kidney research: (1) research aimed at identifying the causative genes for inherited kidney diseases; (2) recent discoveries in cell-based therapies for kidney disease; (3) an examination of the impact of acute kidney injury in renal transplant patients; and (4) the development of a kidney failure risk equation to improve prognosis accuracy. Limitations This review focuses on research conducted by the authors. Implications ...
Source: Canadian Journal of Kidney Health and Disease - August 29, 2014 Category: Urology & Nephrology Source Type: research

Improving prevention, early recognition and management of acute kidney injury after major surgery: results of a planning meeting with multidisciplinary stakeholders
Abstract Purpose of review Acute kidney injury (AKI) is common after major surgery, and is associated with morbidity, mortality, increased length of hospital stay, and high health care costs. Although recent guidelines for AKI provide recommendations for identification of patients at risk, monitoring, diagnosis, and management of AKI, there is lack of understanding to guide successful implementation of these recommendations into clinical practice. Sources of information We h...
Source: Canadian Journal of Kidney Health and Disease - August 26, 2014 Category: Urology & Nephrology Source Type: research

Brief communication: patient satisfaction with the use of tablet computers: a pilot study in two outpatient home dialysis clinics
Conclusions Participants were satisfied with the platform and the time involved for completion of instruments was modest. Routine use of HRQOL measures for clinical purposes may be facilitated through use of tablet computers. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - August 26, 2014 Category: Urology & Nephrology Source Type: research

Cost analysis of in-centre nocturnal compared with conventional hemodialysis
Conclusions Compared to CvHD, provision of ICNHD is more expensive, largely driven by increased staffing costs as patients dialyze longer. Alternate staffing models, including self-care ICNHD with minimal staff, may lead to net cost savings. The incremental cost of treatment should be considered in the context of impact on patient health outcomes, staffing model, and pragmatic factors, such as current capacity for daytime CvHD and the capital costs of new dialysis stations. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 2, 2014 Category: Urology & Nephrology Source Type: research

Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease
Conclusions A significant proportion of HD patients met criteria for subclinical vitamin K deficiency. Of the biomarkers measured, PIVKA-II may be superior given its independence of renal function or dyslipidemia, both of which may confound the other vitamin K biomarkers. Studies in patients with ESKD linking biomarkers of vitamin K status to important patient outcomes, including cardiovascular disease, nutritional status and mortality, are required in order to determine the optimal biomarker for evaluating vitamin K status in this particular population. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 24, 2014 Category: Urology & Nephrology Source Type: research

Estimation of total glomerular number using an integrated disector method in embryonic and postnatal kidneys
Abstract Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a polymorphic group of clinical disorders comprising the major cause of renal failure in children. Included within CAKUT is a wide spectrum of developmental malformations ranging from renal agenesis, renal hypoplasia and renal dysplasia (maldifferentiation of renal tissue), each characterized by varying deficits in nephron number. First presented in the Brenner Hypothesis, low congenital nephron endowment is becoming recognized as an antecedent cause of adult-onset hypertension, a leading cause of coronary heart disease, stroke, a...
Source: Canadian Journal of Kidney Health and Disease - June 17, 2014 Category: Urology & Nephrology Source Type: research

Programmatic variation in home hemodialysis in Canada: results from a nationwide survey of practice patterns
Conclusions There is wide variation between programs in all domains of HHD delivery in Canada. We plan further study of the extent to which differences in approach are related to outcomes. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 10, 2014 Category: Urology & Nephrology Source Type: research

Mortality risk for women on chronic hemodialysis differs by age
Conclusions Women’s survival on chronic hemodialysis varies by age compared to men with a significantly higher mortality in women younger than 45 years old and lower mortality in woman older than 75 years of age. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 3, 2014 Category: Urology & Nephrology Source Type: research

Incentives and organ donation: what’s (really) legal in Canada?
Abstract Purpose of review To date, there has been little analysis of the degree to which emerging incentive initiatives are permissible under Canadian law. The purpose of this review is to examine the relevant law – including legislation and case law – in order to clarify the legality of existing proposed incentive schemes. Sources of information Legislation and case law. Findings Orga...
Source: Canadian Journal of Kidney Health and Disease - May 29, 2014 Category: Urology & Nephrology Source Type: research