Canadian Journal of Kidney Health and Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ambulatory care after acute kidney injury: an opportunity to improve patient outcomes
Abstract Purpose of review Acute kidney injury (AKI) is an increasingly common problem among hospitalized patients. Patients who survive an AKI-associated hospitalization are at higher risk of de novo and worsening chronic kidney disease, end-stage kidney disease, cardiovascular disease, and death. For hospitalized patients with dialysis-requiring AKI, outpatient follow-up with a nephrologist within 90 days of hospital discharge has been associated with enhanced survival. However, most patients who survive an AKI episode do not receive any follow-up nephrolo...
Source: Canadian Journal of Kidney Health and Disease - October 6, 2015 Category: Urology & Nephrology Source Type: research

Assessing the extent to which current clinical research is consistent with patient priorities: a scoping review using a case study in patients on or nearing dialysis
Abstract Purpose of review There is growing acknowledgement that engaging patients to identify their research priorities is important. Using a case study of patients on or nearing dialysis, we sought to assess the extent to which recently completed and ongoing clinical research was consistent with priorities identified by patients, caregivers, and clinicians. Sources of information Over a 4-year sampling frame (January 2010 to December 2013), we systematically searched the m...
Source: Canadian Journal of Kidney Health and Disease - October 1, 2015 Category: Urology & Nephrology Source Type: research

Recurrence of crystalline nephropathy after kidney transplantation in APRT deficiency and primary hyperoxaluria
Abstract Purpose of review To provide transplant physicians with a summary of the pathogenesis and diagnosis of adenine phosphoribosyl transferase (APRT) deficiency and primary hyperoxaluria and, focussed on kidney transplantation, and to discuss interventions aimed at preventing and treating the recurrence of crystalline nephropathy in renal transplant recipients. Source of information Pubmed literature search. ...
Source: Canadian Journal of Kidney Health and Disease - September 15, 2015 Category: Urology & Nephrology Source Type: research

Comorbidity burden at dialysis initiation and mortality: A cohort study
Conclusions The CCI and ESRD-CI have a limited ability to discriminate mortality risk for incident dialysis patients. Acknowledging the frequency with which they are used, this study emphasizes the need to re-examine the usefulness of previously derived comorbidity indices in contemporary dialysis cohorts. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - September 8, 2015 Category: Urology & Nephrology Source Type: research

Frailty and physical function in chronic kidney disease: the CanFIT study
Conclusions People with advanced CKD have a high burden of reduced physical function, especially those with diabetes. We will continue enrollment into the CanFIT study to further understand the clinical history of CKD and frailty in this population. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - September 5, 2015 Category: Urology & Nephrology Source Type: research

Erratum: Oral salt and water versus intravenous saline for the prevention of acute kidney injury following contrast-enhanced computed tomography: study protocol for a pilot randomized trial Salmonella blood stream infections in a tertiary care setting in Ghana
(Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - September 3, 2015 Category: Urology & Nephrology Source Type: research

Acute kidney injury: preclinical innovations, challenges, and opportunities for translation
This article reviews many of the preclinical innovations in acute kidney injury AKI treatment, and explores challenges and opportunities to translate these finding into clinical practice. Sources of Information MEDLINE, ISI Web of Science Findings This paper details areas in biomedical research where translation of pre-clinical findings into clinical trials is ongoing, or nearing a point where trial design is warranted. Further, the paper examines ways t...
Source: Canadian Journal of Kidney Health and Disease - September 1, 2015 Category: Urology & Nephrology Source Type: research

Developing renal allograft surveillance strategies – urinary biomarkers of cellular rejection
Abstract Purpose of review Developing tailored immunosuppression regimens requires sensitive, non-invasive tools for serial post-transplant surveillance as the current clinical standards with serum creatinine and proteinuria are ineffective at detecting subclinical rejection. The purpose of this review is: (i) to illustrate the rationale for allograft immune monitoring, (ii) to discuss key steps to bring a biomarker from bench-to-bedside, and (iii) to present an overview of promising biomarkers for cellular rejection. ...
Source: Canadian Journal of Kidney Health and Disease - August 18, 2015 Category: Urology & Nephrology Source Type: research

Association between serum alkaline phosphatase and primary resistance to erythropoiesis stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial
Conclusions Serum alkaline phosphatase was associated with severity of ESA resistance in ESA-resistant patients with CKD. Large prospective studies are required to confirm this association. (Trial registration: Australian New Zealand Clinical Trials Registry 12608000199314) (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - August 18, 2015 Category: Urology & Nephrology Source Type: research

Coronary artery calcification, cardiovascular events, and death: a prospective cohort study of incident patients on hemodialysis
Conclusions Respondent burden is high for additional testing around the initiation of dialysis. High coronary calcification in patients new to ESRD has a tendency to predict cardiovascular outcomes and death, though effects are attenuated when adjusted for age. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - August 12, 2015 Category: Urology & Nephrology Source Type: research

Chronic kidney disease in congenital heart disease patients: a narrative review of evidence
Abstract Purpose of review Patients with congenital heart disease have a number of risk factors for the development of chronic kidney disease (CKD). It is well known that CKD has a large negative impact on health outcomes. It is important therefore to consider that patients with congenital heart disease represent a population in whom long-term primary and secondary prevention strategies to reduce CKD occurrence and progression could be instituted and significantly change outcomes. There are currently no clear guidelines for clinicians in terms of renal assess...
Source: Canadian Journal of Kidney Health and Disease - August 11, 2015 Category: Urology & Nephrology Source Type: research

The impact and treatment of obesity in kidney transplant candidates and recipients
Abstract The prevalence of obesity in patients with chronic kidney failure and renal transplant candidates has paralleled the epidemic in the general population. The associated risks of surgical complications and long-term cardiovascular death are significant: most transplant centers consider obesity a relative contra-indication for transplant. Few studies have focused on conservative weight loss strategies in transplant patients. Studies using administrative databases have found that only a minority of wait-listed patients lose weight and with no apparent benefit to transplant outco...
Source: Canadian Journal of Kidney Health and Disease - July 31, 2015 Category: Urology & Nephrology Source Type: research

Early outgrowth pro-angiogenic cell number and function do not correlate with left ventricular structure and function in conventional hemodialysis patients: a cross-sectional study
Conclusions These data suggest that in ESRD, the reparative EPC response to cardiac hypertrophy may be blunted. Further investigation of the effects of uremia on EPC physiology and its relationship to cardiac injury are required. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 30, 2015 Category: Urology & Nephrology Source Type: research

Increases in intravenous magnesium use among hospitalized patients: an institution cross-sectional experience
Conclusions This center has witnessed a considerable increase in the use of in-hospital intravenous magnesium over the last 6 years that cannot be explained for by medical indications. The risks and benefits of this therapy deserve further study. If this change in practice is representative of other North American hospitals, it may be responsible for recent drug shortages. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 13, 2015 Category: Urology & Nephrology Source Type: research

Patients with chronic kidney disease and their intent to use electronic personal health records
Conclusions We found that patients with CKD expressed their intention to use ePHRs, and perceive benefits such as personal involvement in their health care and better access to lab results. Studies of CKD patients using ePHRs are needed to determine whether ePHR use improves patient outcomes. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 9, 2015 Category: Urology & Nephrology Source Type: research