Establishing a continuum of acute kidney injury – tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus Conference
Conclusions We have identified minimal data elements and potential data sources necessary to trace the natural history of patients from onset of AKI to long-term outcome. Minimum infrastructure and key barriers to achieving these goals are outlined together with proposed solutions. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Impact of electronic-alerting of acute kidney injury: workgroup statements from the 15 th ADQI Consensus Conference
Abstract Purpose of the review Among hospitalized patients, acute kidney injury is common and associated with significant morbidity and risk for mortality. The use of electronic health records (EHR) for prediction and detection of this important clinical syndrome has grown in the past decade. The steering committee of the 15th Acute Dialysis Quality Initiative (ADQI) conference dedicated a workgroup with the task of identifying elements that may impact the course of events following Acute Kidney Injury (AKI) e-alert. ...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Utilizing electronic health records to predict acute kidney injury risk and outcomes: workgroup statements from the 15 th ADQI Consensus Conference
We describe AKI prediction targets, feature selection, model development, and data display. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Applications for detection of acute kidney injury using electronic medical records and clinical information systems: workgroup statements from the 15 th ADQI Consensus Conference
Abstract Electronic medical records and clinical information systems are increasingly used in hospitals and can be leveraged to improve recognition and care for acute kidney injury. This Acute Dialysis Quality Initiative (ADQI) workgroup was convened to develop consensus around principles for the design of automated AKI detection systems to produce real-time AKI alerts using electronic systems. AKI alerts were recognized by the workgroup as an opportunity to prompt earlier clinical evaluation, further testing and ultimately intervention, rather than as a diagnostic label. Workgroup members agreed with d...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Optimizing administrative datasets to examine acute kidney injury in the era of big data: workgroup statement from the 15 th ADQI Consensus Conference
Abstract Purpose of review The purpose of this review is to report how administrative data have been used to study AKI, identify current limitations, and suggest how these data sources might be enhanced to address knowledge gaps in the field. Objectives 1) To review the existing evidence-base on how AKI is coded across administrative datasets, 2) To identify limitations, gaps in knowledge, and major barriers to scientific progress in AKI related to coding in administrative d...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Acute kidney injury in the era of big data: the 15 th Consensus Conference of the Acute Dialysis Quality Initiative (ADQI)
Abstract The world is immersed in “big data”. Big data has brought about radical innovations in the methods used to capture, transfer, store and analyze the vast quantities of data generated every minute of every day. At the same time; however, it has also become far easier and relatively inexpensive to do so. Rapidly transforming, integrating and applying this large volume and variety of data are what underlie the future of big data. The application of big data and predictive analytics in healthcare holds great promise to drive innovation, reduce cost and improve patient outcomes, health services o...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Circulating angiogenic factors in a pregnant woman on intensive hemodialysis: a case report
Conclusions Our case report expands on the literature regarding intensive hemodialysis and angiogenic factor utilization in pregnant dialysis patients. Our case report suggests that starting intensive dialysis early in pregnancy is safe and concentration of angiogenic factors are similar to those reported for patients without kidney disease, except for PIGF levels, which are somewhat higher. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 23, 2016 Category: Urology & Nephrology Source Type: research

Objective and subjective sleep disorders in automated peritoneal dialysis
Conclusions Despite differences in univariate analyses, after multivariate adjustment, APD patients had similar sleep parameters and sleep architecture and as poor SQ and symptoms of depression as HD patients. Future studies with larger APD cohorts are needed. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 17, 2016 Category: Urology & Nephrology Source Type: research

Reviewer acknowledgement 2015
Contributing reviewers The Editors of Canadian Journal of Kidney Health and Disease would like to thank all our reviewers who have contributed to the journal in Volume 2 (2015). (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 17, 2016 Category: Urology & Nephrology Source Type: research

Consecutive first-morning urine samples to measure change in the albumin-to-creatinine ratio: a pilot study of a home urine collection protocol
Conclusions We successfully used a home urine collection protocol to obtain multiple first-morning urine samples in patients with chronic kidney disease. Statistical efficiency was improved by averaging ACR values from two consecutive first-morning urine samples at baseline and follow-up. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 1, 2016 Category: Urology & Nephrology Source Type: research

Approach to hyponatremia in congestive heart failure: a survey of Canadian specialist physicians and trainees
Conclusions This study identified that there are differences in the understanding of pathophysiology and management strategies for hyponatremia in the context of CHF amongst Canadian specialist physicians and trainees. A more consistent approach to hyponatremia is required and might best be achieved through formal knowledge translation. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - January 20, 2016 Category: Urology & Nephrology Source Type: research

Frequency of bone mineral density testing in adult kidney transplant recipients from Ontario, Canada: a population-based cohort study
Conclusions There is substantial practice variability in BMD testing after transplant. New high-quality information is needed to inform the utility, optimal timing, and frequency of BMD testing in kidney transplant recipients. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - January 16, 2016 Category: Urology & Nephrology Source Type: research

Pedal edema and jugular venous pressure for volume overload in peritoneal dialysis patients
Conclusions The presence of pedal edema is a good indicator of volume overload in peritoneal dialysis patients without cardiac dysfunction, although its absence cannot definitively rule out significant water excess. A JVP of 1 to 3 cm was found to be not a clinically significant sign. We are unable to comment on the diagnostic strength of a low (0 cm) or high (JVP >3 cm) due to poor precision. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - January 13, 2016 Category: Urology & Nephrology Source Type: research

Fluid volume expansion and depletion in hemodialysis patients lack association with clinical parameters
Conclusions The study indicates that volume expansion is highly prevalent in HD population and could not be identified using clinical parameters alone. No clinical parameters were identified that could reliably predict volume status. This study shows that bio-impedance can assist to determine volume status. Volume status, in turn, is not related to intradialytic weight gain and is unable to explain the high incidence of paradoxical hypertension. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - December 22, 2015 Category: Urology & Nephrology Source Type: research

Perceptions of prognostic risks in chronic kidney disease: a national survey
Conclusions Our national survey of nephrologists shows that the risk prediction for major adverse clinical outcomes is valuable in CKD at multiple time frames and risk thresholds. Further research is required in developing relevant and meaningful risk prediction models for clinical decision-making in patient-centered CKD care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - December 20, 2015 Category: Urology & Nephrology Source Type: research