Small interfering RNA targeting NF- κB attenuates lipopolysaccharide-induced acute lung injury in rats
To investigate the anti-inflammatory effects of specific small interfering RNA targeting NF- κB on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. (Source: BMC Physiology)
Source: BMC Physiology - December 28, 2016 Category: Physiology Authors: Ning Li, Yuanbin Song, Wei Zhao, Tingting Han, Shuhui Lin, Oscar Ramirez and Li Liang Source Type: research
Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca2+ sensitivity but not on Ca2+ sparks or BK channels
In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca2+ sparks activate large-conductance Ca2+-activated K+ (BK) channels leading to lowered SMC [Ca2+]i and vasodilation. Here we investigate... (Source: BMC Physiology)
Source: BMC Physiology - November 2, 2016 Category: Physiology Authors: Gayathri Krishnamoorthy, Katrin Reimann and Philine Wangemann Source Type: research
Trimester-specific thyroid hormone reference ranges in Sudanese women
Trimester-specific reference ranges for T3, T4, and TSH need to be established in different communities. Neither Sudan nor other African countries have established trimester-specific reference ranges for TSH, ... (Source: BMC Physiology)
Source: BMC Physiology - October 31, 2016 Category: Physiology Authors: Enaam T. Elhaj, Ishag Adam, Mohamed A. Ahmed and Mohamed F. Lutfi Source Type: research
The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion
Disturbance of acid –base balance in the inner ear is known to be associated with hearing loss in a number of conditions including genetic mutations and pharmacologic interventions. Several previous physiologic... (Source: BMC Physiology)
Source: BMC Physiology - August 11, 2016 Category: Physiology Authors: Hiromitsu Miyazaki, Philine Wangemann and Daniel C. Marcus Source Type: research
The novel in vitro reanimation of isolated human and large mammalian heart-lung blocs
In vitro isolated heart preparations are valuable tools for the study of cardiac anatomy and physiology, as well as for preclinical device testing. Such preparations afford investigators a high level of hemody... (Source: BMC Physiology)
Source: BMC Physiology - June 4, 2016 Category: Physiology Authors: Ryan P. Goff, Brian T. Howard, Stephen G. Quallich, Tinen L. Iles and Paul A. Iaizzo Source Type: research
Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors
Evidence suggests a critical role for the renin-angiotensin system in regulating renal function during postnatal development. However, the physiological relevance of a highly elevated renin-angiotensin system ... (Source: BMC Physiology)
Source: BMC Physiology - April 18, 2016 Category: Physiology Authors: Angela E. Vinturache and Francine G. Smith Source Type: research
Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective
The cell type, cell status and specific localization of Prothymosin α (PTMA) within cells seemingly determine its function. PTMA undergoes 2 types of protease proteolytic modifications that are useful in eluci... (Source: BMC Physiology)
Source: BMC Physiology - March 1, 2016 Category: Physiology Authors: Caroline Mwendwa Kijogi, Christopher Khayeka-Wandabwa, Keita Sasaki, Yoshimasa Tanaka, Hiroshi Kurosu, Hayato Matsunaga and Hiroshi Ueda Source Type: research
The normal electrocardiograms in the conscious newborn lambs in neonatal period and its progression
Veterinary cardiology, especially electrocardiography, has shown major advancements for all animal species. Consequently, the number of ovine species used as experimental animals has increased to date. Few stu... (Source: BMC Physiology)
Source: BMC Physiology - January 19, 2016 Category: Physiology Authors: Karoline Koether, Carla Maria Vela Ulian, Maria Lucia Gomes Lourenço, Renato Souza Gonçalves, Mateus José Sudano, Raíssa Karolliny Salgueiro Cruz, Naiana da Silva Branchini, Angélica Alfonso and Simone Biagio Chiacchio Source Type: research
An investigation of the efficacy and mechanism of contrast-enhanced X-ray Computed Tomography utilizing iodine for large specimens through experimental and simulation approaches
Iodine-based solutions have long been known to be effective in aiding the differentiation among soft tissues in both fundamental anatomical research and for clinical diagnoses. Recently the combination of this... (Source: BMC Physiology)
Source: BMC Physiology - December 21, 2015 Category: Physiology Authors: Zhiheng Li, Julia A. Clarke, Richard A. Ketcham, Matthew W. Colbert and Fei Yan Source Type: research
Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow
Neurogenic pulmonary edema (NPE) is a non-cardiogenic form of pulmonary edema that can occur consequent to central neurologic insults including stroke, traumatic brain injury, and seizure. NPE is a public heal... (Source: BMC Physiology)
Source: BMC Physiology - October 9, 2015 Category: Physiology Authors: Shadi Khademi, Melinda A. Frye, Kimberly M. Jeckel, Thies Schroeder, Eric Monnet, Dave C. Irwin, Patricia A. Cole, Christopher Bell, Benjamin F. Miller and Karyn L. Hamilton Source Type: research
Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow
Conclusion:
Cerebral hypoxia, with systemic normoxia, is not systematically associated with an increase in oxidative stress and compensatory antioxidant enzymes in lung, suggesting oxidative stress did not contribute to NPE in lung. However, increased SNS activity may play a role in the induction of NPE during hypoxia. (Source: BMC Physiology)
Source: BMC Physiology - October 9, 2015 Category: Physiology Authors: Shadi KhademiMelinda FryeKimberly JeckelThies SchroederEric MonnetDave IrwinPatricia ColeChristopher BellBenjamin MillerKaryn Hamilton Source Type: research
Effects of postnatal growth restriction and subsequent catch-up growth on neurodevelopment and glucose homeostasis in rats
There is increasing evidence that poor growth of preterm infants is a risk factor for poor long-term development, while the effects of early postnatal growth restriction are not well known. We utilized a rat m... (Source: BMC Physiology)
Source: BMC Physiology - June 5, 2015 Category: Physiology Authors: Erica E. Alexeev, Bo Lönnerdal and Ian J. Griffin Source Type: research
Effects of postnatal growth restriction and subsequent catch-up growth on neurodevelopment and glucose homeostasis in rats
Background:
There is increasing evidence that poor growth of preterm infants is a risk factor for poor long-term development, while the effects of early postnatal growth restriction are not well known. We utilized a rat model to examine the consequences of different patterns of postnatal growth and hypothesized that early growth failure leads to impaired development and insulin resistance. Rat pups were separated at birth into normal (N, n = 10) or restricted intake (R, n = 16) litters. At d11, R pups were re-randomized into litters of 6 (R-6), 10 (R-10) or 16 (R-16) pups/dam. N pups remained in litters of 10 pups/...
Source: BMC Physiology - June 5, 2015 Category: Physiology Authors: Erica AlexeevBo LönnerdalIan Griffin Source Type: research
Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension
Elevated blood pressure is an important global health problem, and in-utero under-nutrition may be an important factor in the pathogenesis of hypertension. In the present study, we tested the hypothesis that ante... (Source: BMC Physiology)
Source: BMC Physiology - May 14, 2015 Category: Physiology Authors: Ravi Goyal, Jonathan Van-Wickle, Dipali Goyal and Lawrence D. Longo Source Type: research
