Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca2+ sensitivity but not on Ca2+ sparks or BK channels

In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca2+ sparks activate large-conductance Ca2+-activated K+ (BK) channels leading to lowered SMC [Ca2+]i and vasodilation. Here we investigate...

Source: BMC Physiology - November 2, 2016 Category: Physiology Authors: Gayathri Krishnamoorthy, Katrin Reimann and Philine Wangemann Source Type: research