Reductions in expression of growth regulating genes in skeletal muscle with age in wild type and myostatin null mice
Conclusions:
Overall, these data suggest the downregulation of these growth-regulating genes with age might play a role in the coordinated cessation of muscle growth similar to organ growth but likely have a limited role in the differences between sexes or genotypes. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - March 28, 2014 Category: Physiology Authors: Jennifer JonesKellie KroscherAnna Dilger Source Type: research
Cardiac responses to elevated seawater temperature in Atlantic salmon
Conclusions:
Long-term exposure of Atlantic salmon to 19[degree sign]C resulted in cardiac gene and protein expression changes indicating that the unfolded protein response, vascularization, remodeling of connective tissue and altered innate immune responses were part of the cardiac acclimation or response to elevated temperature. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - March 1, 2014 Category: Physiology Authors: Sven JørgensenVicente CastroAleksei KrasnovJacob TorgersenGerrit TimmerhausErnst HevrøyTom HansenSissel SusortOlav BreckHarald Takle Source Type: research
Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish
Conclusions:
We conclude that the zebrafish is an attractive model for the study of the KCNQ (Kv7) superfamily of genes, and are important to processes involved in neuronal excitability, cardiac anomalies, epileptic seizures, and hearing loss or tinnitus. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - February 20, 2014 Category: Physiology Authors: Calvin WuKanishk SharmaKyle LasterMohamed HersiChristina TorresThomas LukasErnest Moore Source Type: research
RETRACTION: The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners
The authors have retracted the article [1]. Following publication of the article irregularities within the Northern blot figures were brought to the attention of the editors and subsequently confirmed by an investigation by the University of Rome Tor Vergata. We apologize to all affected parties. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - January 10, 2014 Category: Physiology Authors: Gabriella MarfeMarco TafaniBruna PucciCarla Di StefanoManuela IndelicatoAngela AndreoliMatteo RussoVincenzo ManziPaola Sinibaldi-Salimei Source Type: research
Retraction Note: The effect of marathon on mRNA expression of anti-apoptotic andpro-apoptotic proteins and sirtuins family in male recreational long-distancerunners
(Source: BMC Physiology)
Source: BMC Physiology - January 10, 2014 Category: Physiology Authors: Gabriella Marfe, Marco Tafani, Bruna Pucci, Carla Di Stefano, Manuela Indelicato, Angela Andreoli, Matteo Antonio Russo, Paola Sinibaldi-Salimei and Vincenzo Manzi Source Type: research
RETRACTION: The effect of marathon on mRNA expression of anti-apoptotic and
pro-apoptotic proteins and sirtuins family in male recreational long-distance
runners
The authors have retracted the article [1]. Following publication of the article irregularities within the Northern blot figures were brought to the attention of the editors and subsequently confirmed by an investigation by the University of Rome Tor Vergata. We apologize to all affected parties. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - January 10, 2014 Category: Physiology Authors: Gabriella MarfeMarco TafaniBruna PucciCarla Di StefanoManuela IndelicatoAngela AndreoliMatteo RussoPaola Sinibaldi-SalimeiVincenzo Manzi Source Type: research
Inference of mechanical states of intestinal motor activity using hidden Markov models
Conclusions: The identification of mechanical muscles states based on gut diameter and intraluminal pressure was possible by modelling muscle activation with a hidden Markov model. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - December 11, 2013 Category: Physiology Authors: Lukasz WiklendtMarcello CostaPhil Dinning Source Type: research
The endotoxin/toll-like receptor-4 axis mediates gut microvascular dysfunction associated with post-prandial lipidemia
Conclusions:
Dietary oils may be negative regulators of SIRT1 which activate the innate immune response through the endotoxin/TLR4 axis. Our findings establish a link between innate immunity (i.e. the endotoxin/TLR4 axis) and epigenetic controls mediated by SIRT1 in the genesis of diet associated vascular stress. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - November 12, 2013 Category: Physiology Authors: Ping YiJia PangJonathan AlexanderChantal Rivera Source Type: research
Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice
Conclusions:
Aerobic and anaerobic performance parameters can be improved in training at maximal lactate steady state during 8 weeks without leading to DNA damage in peripheral blood and skeletal muscle cells or to oxidative stress in skeletal muscle cells. However, overtraining induced by downhill running training sessions is associated with DNA damage in peripheral blood and skeletal muscle cells, and with oxidative stress in skeletal muscle cells and total blood. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - October 8, 2013 Category: Physiology Authors: Bruno PereiraJosé PauliLusânia AntunesEllen de FreitasMara de AlmeidaVinícius de Paula VenâncioEduardo RopelleClaudio de SouzaDennys CintraMarcelo PapotiAdelino da Silva Source Type: research
Estrogen-related receptor ß deficiency alters body composition and response to restraint stress
Conclusions:
Loss of Errβ affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice. These results indicate that Errβ alters the function of the hypothalamic-pituitary-adrenocortical axis and indicates a role for Errβ in regulating stress response. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - September 22, 2013 Category: Physiology Authors: Mardi ByerlyRoy SwansonG WongSeth Blackshaw Source Type: research
Estrogen-related receptor beta deficiency alters body composition and response to restraint stress
Conclusions:
Loss of Errbeta affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice. These results indicate that Errbeta alters the function of the hypothalamic-pituitary-adrenocortical axis and indicates a role for Errbeta in regulating stress response. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - September 22, 2013 Category: Physiology Authors: Mardi ByerlyRoy SwansonG WongSeth Blackshaw Source Type: research
Dynamically regulated miRNA-mRNA networks revealed by exercise
Transcriptional changes of mRNAs in athletes undergoing moderate exercise, followed by a recovery period, reveals miRNA-mRNA networks dynamically regulated during this process and provides insight into the regulatory role of these molecules in stress adaptation. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - June 7, 2013 Category: Physiology Authors: Alexander TonevitskyDiana MaltsevaAsghar AbbasiTimur SamatovDmitry SakharovMaxim ShkurnikovAlexey LebedevVladimir GalatenkoAnatoly GrigorievHinnak Northoff Source Type: research
Significance of KATP channels, L-type Ca2+ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles In vivo
Conclusions:
We conclude that: 1) L-type Ca2+ channels are central to oxygen sensing, 2) KATP channels are permissive for the arteriolar response to oxygen, but are not directly involved in the oxygen sensing mechanism and 3) CYP450-4A mediated 20-HETE production is involved in vasoconstriction to high PO2. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - May 12, 2013 Category: Physiology Authors: Anh NgoMads RiemannNiels-Henrik Holstein-RathlouChristian Torp-PedersenLars Jensen Source Type: research
Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding
Conclusion:
This study demonstrates that re-synthesis of muscle proteins following starvation is not critically dependent on endocrine liver-derived IGF-I. (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - May 8, 2013 Category: Physiology Authors: Britt-Marie IresjöJohan SvenssonClaes OhlssonKent Lundholm Source Type: research
cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium
Secretion of Cl- by the semicircular canal duct (SCCD) epithelium is regulated by protein kinase A and glucocorticoids with the ion likely to be transported across the apical membrane by cystic fibrosis transmembrane conductance regulator (CFTR) (Source: BMC Physiology - Latest articles)
Source: BMC Physiology - Latest articles - March 27, 2013 Category: Physiology Authors: Satyanarayana PondugulaSuresh KampalliTao WuRobert De LisleNithya RaveendranDonald HarbidgeDaniel Marcus Source Type: research
