Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease
DiscussionIn anticipation of the emergence of more reliable CSF analysis platforms, the manuscript offers important guidance to health-care practitioners and suggestions for implementation and future research. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 10, 2018 Category: Geriatrics Source Type: research

Analysis of tauopathy research funding between 2006 and 2016 reveals critical gaps in research priorities
Publication date: Available online 9 October 2018Source: Alzheimer's & DementiaAuthor(s): Cara M. Altimus, Kirstie Keller, Patrick Brannelly, Erin Ross, Chang-Ting Lin, Ekemini A.U. Riley, LaTese Briggs, Jeremy Smith, Melissa StevensAbstractNeurodegenerative diseases encompass a range of diagnoses, such as Alzheimer's disease and Parkinson's disease. Despite decades of advancements in understanding the neurobiology of individual diseases, this class has few disease-modifying therapeutics and a paucity of biomarkers for diagnosis or progression. However, tau protein aggregation has emerged as a potential unifying factor acr...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 9, 2018 Category: Geriatrics Source Type: research

Participant satisfaction with dementia prevention research: Results from Home-Based Assessment trial
DiscussionOlder adults' participation in research was primarily motivated by altruism. Methodologies that facilitate human contact, encourage feedback and novelty of tasks should be incorporated into future trial design. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease
DiscussionThese results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Contents
Publication date: October 2018Source: Alzheimer's & Dementia, Volume 14, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2018Source: Alzheimer's & Dementia, Volume 14, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: October 2018Source: Alzheimer's & Dementia, Volume 14, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: October 2018Source: Alzheimer's & Dementia, Volume 14, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: October 2018Source: Alzheimer's & Dementia, Volume 14, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 5, 2018 Category: Geriatrics Source Type: research

Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms
DiscussionOur findings provide evidence for genetic overlap, mostly due to apolipoprotein E (APOE), between vascular pathologies and AD dementia. The association between AD polygenic risk and late-life cognition is mediated in part via effects on vascular pathologies. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 20, 2018 Category: Geriatrics Source Type: research

An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease—A cohort study of 95,442 individuals
DiscussionLow baseline levels of complement C3 were associated with high risk of Alzheimer's disease. The risk was amplified in APOE ε44 highly susceptible individuals, and these findings were substantiated by a Mendelian randomization approach, potentially implying causality. Based on these findings, we present and thoroughly discuss an updated Alzheimer hypothesis incorporating low complement C3 levels. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 20, 2018 Category: Geriatrics Source Type: research

Progress and future challenges in aging and diversity research in the United States
This report disseminates the research priorities that emerged from this conference, building on an earlier Gerontological Society of America preconference. We review key racial/ethnic differences in cognitive aging and dementia and identify current knowledge gaps in the field. We advocate for a systems-level framework for future research whereby environmental, sociocultural, behavioral, neuropathological, genetic, and psychometric levels of analysis are examined together to identify pathways and mechanisms that influence disparities. We then discuss steps to increase the recruitment and retention of racial/ethnic minoritie...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 20, 2018 Category: Geriatrics Source Type: research

Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years
DiscussionThese estimates can be used to guide planning and interventions related to caring for the ADRD population and supporting caregivers. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 20, 2018 Category: Geriatrics Source Type: research

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance
Publication date: Available online 14 September 2018Source: Alzheimer's & DementiaAuthor(s): Yaakov Stern, Eider M. Arenaza-Urquijo, David Bartrés-Faz, Sylvie Belleville, Marc Cantilon, Gael Chetelat, Michael Ewers, Nicolai Franzmeier, Gerd Kempermann, William S. Kremen, Ozioma Okonkwo, Nikolaos Scarmeas, Anja Soldan, Chinedu Udeh-Momoh, Michael Valenzuela, Prashanthi Vemuri, Eero Vuoksimaa, Eider M. Arenaza Urquiljo, David Bartrés-Faz, Sylvie BellevilleAbstractSeveral concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 16, 2018 Category: Geriatrics Source Type: research

High prevalence of parkinsonism in patients with MCI or mild Alzheimer's disease
ConclusionThe prevalence rate of the coexistence of mild parkinsonism in MCI or mild AD may be higher than previously recognized. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 16, 2018 Category: Geriatrics Source Type: research