Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
This study aimed to systematically review any previous studies that involved resilient APOE ε4 homozygotes and to identify possible modifying or protective genetic factors.ResultsFifteen studies met our inclusion criteria and reported genetic factors contributing to reduced risk. We found that only two single nucleotide polymorphisms, CASP7 rs10553596 and SERPINA3 rs4934-A/A, had strong evidence.DiscussionWe found a paucity of studies adequately designed to discover protective genetic factors against LOAD. Many studies combined APOE ε4 homozygotes and heterozygotes together because of small sample sizes and used control ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 8, 2019 Category: Geriatrics Source Type: research

Cognitive function after surgery with regional or general anesthesia: A population-based study
ConclusionsOlder adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative
DiscussionNP criteria produced a reversion rate that is consistent with, albeit modestly improved from, reversion rates in meta-analyses. Reverters’ biomarker profiles and progression rates suggest that NP criteria accurately tracked with underlying pathophysiologic status. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid
DiscussionOur systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
DiscussionThe results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals
DiscussionCorrelation patterns between tau burden and atrophy in the amyloid-β–negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries
DiscussionAscertainment of etiologic dementia subtype may inform hereditary risk and facilitate financial and care planning. Use of dementia specialty care was low, particularly for Hispanics and Asians, and associated with more detection of etiological subtype. Dementia-related professional development for nonspecialists is urgent given their central role in dementia diagnosis and care. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 5, 2019 Category: Geriatrics Source Type: research

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium
DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 31, 2019 Category: Geriatrics Source Type: research

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
DiscussionThe regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 28, 2019 Category: Geriatrics Source Type: research

Reply to “Down Syndrome Cognitive Marker's Significance in Alzheimer's Disease and Dementia Management”
Publication date: Available online 23 August 2019Source: Alzheimer's & DementiaAuthor(s): Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Tamara Al-Janabi, Kin Y. Mok, John Hardy, Andre Strydom (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 24, 2019 Category: Geriatrics Source Type: research

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Publication date: Available online 18 August 2019Source: Alzheimer's & DementiaAuthor(s): Binyin Li, Yixi He, Jianfang Ma, Pei Huang, Juanjuan Du, Li Cao, Yan Wang, Qin Xiao, Huidong Tang, Shengdi ChenAbstractObjectiveGut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia.BackgroundAD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, wher...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 18, 2019 Category: Geriatrics Source Type: research

Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid
This study verified the agreement between CSF and blood exosomal biomarkers and confirmed that exosomal Aβ42, T-tau, and P-T181-tau have the same capacity as those in CSF for the diagnosis of AD and aMCI. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Lucidity in dementia: A perspective from the NIA
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Basil A. Eldadah, Elena M. Fazio, Kristina A. McLindenAbstractIn this issue of Alzheimer's & Dementia, Mashour et al. propose the intriguing hypothesis that some manifestations of late-stage dementia are reversible, albeit transiently. Calling this phenomenon paradoxical lucidity, their paper follows a 2018 workshop sponsored by the National Institute on Aging that assessed the state of knowledge on lucidity in dementia and identified areas ripe for further study. The National Institute on Aging has since released two funding opportun...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Recommendations for a new perioperative cognitive impairment nomenclature
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Lisbeth Evered, Brendan Silbert, David A. Scott, Roderic G. Eckenhoff (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research