Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

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Publication date: December 2018Source: Alzheimer's & Dementia, Volume 14, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 3, 2018 Category: Geriatrics Source Type: research

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome
DiscussionOur findings address uncertainties around the development of randomized controlled trials to delay cognitive decline in DS. Such trials are essential to reduce the high burden of dementia in people with DS and could serve as proof-of-principle trials for some drug targets. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2018 Category: Geriatrics Source Type: research

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis
We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease.MethodsNine middle-aged (mean = 11.2 years) and nine aged (mean = 21.7 years) female vervet/African green monkeys underwent cerebrospinal fluid collection, gait speed measurement, and neuroimaging before neuropathologic assessment.Resultsβ-amyloid plaques were identified in all aged vervets and paired helical filament tau immunoreactivity was observed in all animals. Cerebrospinal fluid β-amyloid42 and gait speed correlated negatively with age and plaque density. Greater plaq...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 21, 2018 Category: Geriatrics Source Type: research

Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia
DiscussionThe WHELD intervention has clinical and economic benefits when used in residents with clinically significant agitation. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 21, 2018 Category: Geriatrics Source Type: research

A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
DiscussionThe most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 14, 2018 Category: Geriatrics Source Type: research

The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach
We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence-based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N-of-1 effectiveness (trial registered at ClinicalTrials.gov NCT03687710). Prior preliminary results suggest that the clinical practice of AD risk reduction is feasible, with measurable improvements in cognition and biomarkers of AD risk. We propose using these early findings as a foundation to evaluate the...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 14, 2018 Category: Geriatrics Source Type: research

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study
DiscussionExploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 12, 2018 Category: Geriatrics Source Type: research

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
DiscussionIn vitro phagocytosis of hPSC monocytes and tMGs was not affected by the TREM2+/R47H mutation but was significantly impaired in TREM2+/− and TREM2−/− progeny. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 12, 2018 Category: Geriatrics Source Type: research

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease
DiscussionThe forms of tau in CSF and plasma are distinct, but in each specimen type, the levels of certain fragments are increased in AD. Measurement of plasma NT1 tau should be aggressively pursued as a potential blood-based screening test for AD/AD-MCI. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 11, 2018 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: November 2018Source: Alzheimer's & Dementia, Volume 14, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 9, 2018 Category: Geriatrics Source Type: research

Contents
Publication date: November 2018Source: Alzheimer's & Dementia, Volume 14, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 9, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: November 2018Source: Alzheimer's & Dementia, Volume 14, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 9, 2018 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: November 2018Source: Alzheimer's & Dementia, Volume 14, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 9, 2018 Category: Geriatrics Source Type: research

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Publication date: November 2018Source: Alzheimer's & Dementia, Volume 14, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 9, 2018 Category: Geriatrics Source Type: research

Military-related risk factors for dementia
DiscussionThe following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 8, 2018 Category: Geriatrics Source Type: research