Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

Publication date: Available online 14 September 2018Source: Alzheimer's & DementiaAuthor(s): Yaakov Stern, Eider M. Arenaza-Urquijo, David Bartrés-Faz, Sylvie Belleville, Marc Cantilon, Gael Chetelat, Michael Ewers, Nicolai Franzmeier, Gerd Kempermann, William S. Kremen, Ozioma Okonkwo, Nikolaos Scarmeas, Anja Soldan, Chinedu Udeh-Momoh, Michael Valenzuela, Prashanthi Vemuri, Eero Vuoksimaa, Eider M. Arenaza Urquiljo, David Bartrés-Faz, Sylvie BellevilleAbstractSeveral concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these constructs and the appropriate ways to apply them to research. Therefore the reserve, resilience, and protective factors professional interest area, established under the auspices of the Alzheimer's Association, established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance. The workgroup also evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts. The workgroup hope...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research